42BR – Unique Vascular Niche in Breast Cancer Progression

Status: Filled – Intern: Vince Bolus
Intern: Vince Bolus
Faculty Name: bin-ren
UAB Department: Surgery
UAB School: Medicine
Campus Address: WTI 620E
Telephone Number: (205) 996-2582
Email: bren98@uab.edu or Click to Send E-Mail
For how many summers have you served as a preceptor: 1
CCC Research Area: Cancer Biology
Number of hours per week that the preceptor will personally supervise or work with the intern: 2
Other faculty, staff, or graduate students who may help to supervise the intern:
1. Dr. Akil
2. Gloria
Title of Project: 42BR – Unique Vascular Niche in Breast Cancer Progression
Project Description:

In various solid cancers, endothelial cells (ECs) promote self-renewal of tumor-initiating cells (TICs) or cancer stem cells (CSCs) by direct cell–cell contact or activation of Notch signaling. Microvascular remodeling and arterioles are critical to the progression of breast, lung and skin cancers, for which the differentiation of microvascular ECs (MVECs) is essential in the tumor microenvironment (TME). MVEC differentiation into arteriolar EC may create a unique vascular niche to enhance the self-renewal capacity of CSCs due to an increase in arterial markers, ephrin B2 and delta-like ligand 4 (DLL4, a key ligand in the Notch pathway). This proposal challenges current antiangiogenic therapy against solid tissue cancers by elucidating mechanisms of arteriolar differentiation of tumor-associated (TA) MVECs or TAECs and targeting both arteriolar remodeling and CSCs to control metastasis of estrogen receptor-positive breast cancer (ER+BC).

Project Status: Already up and running
Location of Project: Birmingham, AL (UAB)
Proposed Start Date: May 4, 2020
Proposed End Date: August 28, 2020
Expected work schedule for intern: Not very flexible, intern MUST be at work on certain days of the week and at certain times of the day (as may be necessary to interview patients, attend lab meetings, process samples, etc.) and should contribute full-time effort.
Category of Project: Laboratory Research
Cancer topic: Breast, Pancreas
Does this project involve human subjects: No
Does this project involve animal subjects: Yes

Grow genetically engineered cells and do functional screening for CD36 small chemical molecule inhibitor.


Write an abstract and prepare for a poster with the PI and PI’s postdoctoral fellow.


Present his results in the lab meeting and UAB CaRes program.

Preceptor will provide intern with access to the following:
Office or desk space, Computer and printer, Laboratory work bench space, Supplies needed to complete project, Equipment needed to complete project
Likelihood that intern will be included as an author on one or more publications
related to this summer research project:
Very likely
Areas in which the ideal candidates will have experience:
Biochemistry, Cell Biology, Laboratory Skills, basic knowledge, Literature Review Skills, Molecular Biology, Pharmacology