Status: Filled – Intern: Minh Chung
Intern: Minh Chung
Faculty Name: nabiha-yusuf
UAB Department: Dermatology
UAB School: Medicine
Campus Address: 1670 University Boulevard, VH566A, Box 202
Telephone Number: (205) 934-7432
Email: nabihayusuf@uabmc.edu or Click to Send E-Mail
For how many summers have you served as a preceptor: 3 or more
CCC Research Area: Cancer Chemoprevention
Number of hours per week that the preceptor will personally supervise or work with the intern: 10
Other faculty, staff, or graduate students who may help to supervise the intern:
1. M. Asif Sherwani
2. Mualla Eraslan
Title of Project: 17NY – Pharmacological inhibition of skin cancer
Project Description:
Ultraviolet (UV) B radiation (290-320 nm) is an important trigger for suppression of immune responses and for the initiation of non-melanoma skin cancers. UVB-induced immunosuppression is a major risk factor for skin cancer. In the United States alone, over 3.5 million new cases of this malignancy are diagnosed each year. The epidemic of skin cancer represents a major public health issue and is a tremendous cost to healthcare systems in the United States and worldwide [5]. When UVB-induced DNA damage, in the form of cyclobutane pyrimidine dimers (CPDs) occurs in cells, there is a meticulous attempt to repair it through the activation of DNA repair enzymes. Toll like receptor-4 (TLR4) belongs to the family of innate immune receptors, and play an important role in mediating immune responses in various pathological conditions, TLR4 signals primarily via myeloid differentiation primary response 88 (MyD88) or TIR-domain-containing adapter-inducing interferon-β (TRIF) pathways. TLR4 has been shown to play an important role in regulation of UVB-induced damage and immunosuppression. Pharmacological antagonist of TLR4 is currently being tested in clinical trials. There is no information on the role of TLR4 antagonist in modulation of DNA damage and prevention of UVB induced skin tumors. The objective of this proposal is to address the role elicited by TLR4 antagonist in prevention of UVB induced cutaneous tumors.
Project Status: Already up and running
Location of Project: Birmingham, AL (UAB)
Proposed Start Date: May 4, 2020
Proposed End Date: August 28, 2020
Expected work schedule for intern: Flexible, intern can largely set his or her own schedule (as for students who are instructed how to proceed and are permitted to work independently with weekly guidance) and should contribute full-time effort.
Category of Project: Laboratory Research
Cancer topic: Skin
Does this project involve human subjects: No
Does this project involve animal subjects: Yes
Duty:
1.
Process samples from carcinogenesis experiment
2.
Perform molecular biology and immunological assays
3.
Analyze data and write report
Preceptor will provide intern with access to the following:
Office or desk space, Computer and printer, Laboratory work bench space, Supplies needed to complete project, Equipment needed to complete project
Likelihood that intern will be included as an author on one or more publications
related to this summer research project: Very likely
Areas in which the ideal candidates will have experience:
Animal Research, Cell Biology, Immunology, Laboratory Skills, advanced knowledge, Literature Review Skills, Molecular Biology, Scientific Writing Skills
