10YY – Determine the mechanism whereby Runx2 deficiency in osteoblasts induces chemoresistance of multiple myeloma

Status: Available
Faculty Name: yang-yang
UAB Department: Department of Pathology
UAB School: School of Medicine
Campus Address: Volker Hall Building, Room G035; 1670 University Blvd Birmingham, Alabama 35233
Telephone Number: (205) 996-6228
Email: yangyang@uabmc.edu or Click to Send E-Mail
For how many summers have you served as a preceptor: 3 or more
CCC Research Area: Cancer Biology
Number of hours per week that the preceptor will personally supervise or work with the intern: 5
Other faculty, staff, or graduate students who may help to supervise the intern:
1. Dr. Chao Zhang
Title of Project: 10YY – Determine the mechanism whereby Runx2 deficiency in osteoblasts induces chemoresistance of multiple myeloma
Project Description:

Chemoresistance is a major cause of multiple myeloma (MM) relapse and patient mortality. Bortezomib is a front line anti-MM drug and one of most effectively used chemotherapeutic drugs on MM patients. Our previous studies have demonstrated that MM cells secrete soluble factors and suppress osteoblastogenesis via the inhibition of Runt-related transcription factor 2 (Runx2) in osteoblasts (OBs) in bone, and this OB-Runx2 deficiency, in turn, promotes myeloma cell resistance to the treatment of Bortezomib. In this project, we will investigate the mechanisms of OB-Runx2 deficiency induced Bortezomib resistance and seek a strategy for overcoming the drug resistance.

Project Status: Already up and running
Location of Project: Birmingham, AL (UAB)
Proposed Start Date: June 1, 2020
Proposed End Date: August 21, 2020
Expected work schedule for intern: Flexible, intern can largely set his or her own schedule (as for students who are instructed how to proceed and are permitted to work independently with weekly guidance) and should contribute full-time effort.
Category of Project: Laboratory Research
Cancer topic: Multiple myeloma
Does this project involve human subjects: No
Does this project involve animal subjects: Yes

Cell culture


Experimental analyses (e.g., Western blot and PCR )


Analyze data and write an abstract

Preceptor will provide intern with access to the following:
Office or desk space, Computer and printer, Laboratory work bench space, Supplies needed to complete project, Equipment needed to complete project
Likelihood that intern will be included as an author on one or more publications
related to this summer research project:
Very likely
Areas in which the ideal candidates will have experience:
Biochemistry, Cell Biology, Laboratory Skills, basic knowledge, Molecular Biology, Statistics and Data Management, basic knowledge