35RA – Effect of Treatment Modalities and Patient Characteristics on Survival in Gynecologic Cancer

Status: Filled – McKenzie Foxall
Intern: McKenzie Foxall
Faculty Name: rebecca-arend-2
Primary Faculty Appointment: UAB
UAB/HA Department: OB/GYN
Campus Address: 1700 6th Avenue South (Women & Infants Center), Room 10250
Telephone Number: (205) 934-4986
Email: rarend@uabmc.edu or Click to Send E-Mail
For how many summers have you served as a preceptor: 2
CCC Research Area: Experimental Therapeutics
Number of hours per week that the preceptor will personally supervise or work with the intern: 5
Other faculty, staff, or graduate students who may help to supervise the intern:
1. Carly Bess Scalise
2.
Title of Project: 35RA – Effect of Treatment Modalities and Patient Characteristics on Survival in Gynecologic Cancer
Project Description:

The primary objective of this study is to determine if various methods of treatment, including type and dose of chemotherapy, extent of surgical debulking (removal of as much of the tumor possible) and adjuvant radiation therapy affect progression free and overall survival in the primary treatment of gynecologic cancer. Our secondary objective is to determine if various methods of treatment, including type and dose of chemotherapy, surgical re-excision, and radiation therapy affect progression free and overall survival in recurrent gynecologic cancer.

Treatment options for gynecologic cancer are constantly changing. In the last decade, new methods of treatment have emerged which have proved to be efficacious. The decision to employ new therapeutic options and the decision to choose certain chemotherapy drugs for recurrence is a complex decision that combines patient factors, tumor characteristics, and provider experience. The UAB Division of Gynecologic Oncology treats hundreds of women with gynecologic cancer annually and serves a diverse patient population. It is prudent that we evaluate, in a retrospective fashion, the various treatment modalities and their effect on progression free and overall survival. Additionally, given the multiple patient factors in a diverse patient population, it is important to evaluate if certain patient characteristics affect disease treatment and survival. The results of this study will help us better counsel patients on their outcomes and may eventually affect the type of treatment selected for an individual patient.

This is a retrospective chart review with no participant contact. Utilizing the gynecology oncology clinic Redcap database, as well as gynecology oncology clinic billing records ,and the surgical pathology billing records, all patients who have a diagnosis of gynecologic cancer will be identified using ICD-9 codes. A chart review will be performed. Based on the inclusion and exclusion criteria as listed above, subjects will be identified and their medical records will be further reviewed for the purpose of this study.

Project Status: Will begin on or before the CaRES student’s start date
Location of Project: Birmingham, AL (UAB)
Proposed Start Date: May 3, 2021
Proposed End Date: July 23, 2021
Expected work schedule for intern: Flexible, intern can largely set his or her own schedule (as for students who are instructed how to proceed and are permitted to work independently with weekly guidance) and should contribute full-time effort.
Number of days that the student will be expected to come physically to UAB:
1 day or a few days as needed
Category of Project: Clinical (Patient Care) Research
Cancer topic: Cervix, Ovary, Uterus
Does this project involve human subjects: Yes
Does this project involve animal subjects: No
Duty:
1.

Literature and existing resources review

2.

Clinical data abstraction via chart review from the Electronic Medical Record

3.

Data analysis (with supervision) of factors affecting treatment and survival in gynecologic oncology patients

Preceptor will provide intern with access to the following: Office or desk space
Likelihood that intern will be included as an author on one or more publications related to this summer research project: Very likely
Areas in which the ideal candidates will have experience: Clinical Oncology, Literature Review Skills, Statistics and Data Management, basic knowledge