Doxorubicin (DOX, an anthracycline) is a widely used chemotherapy agent against various forms of cancer. However, it is known to induce dose-dependent cardiotoxicity that leads to adverse cardiac complications. Our lab investigates the role of microRNA-377 in anticancer drug-induced cardiotoxicity in mice. Read the full article at: https://www.frontiersin.org/articles/10.3389/fcvm.2021.737826/full
The work is supported through grants from National Institutes of Health (NIH) and American Heart Association.
Research Intern, Mr. Terry successfully completes 8-weeks UAB-Center for Community OutReach Development (CORD) Summer Science Program (Blazing to Biomedical Careers Program). At the end of the program, interns showcase their work through poster presentation. Terry’s research work is focused on Midkine, a heparin-binding growth and its role in fibroblast biology. We wish the best to Terry.
Drs. Sarojini Singh and Mallikarjun Patil co-mentored Terry. Thanks to their fantastic team effort!
Ms. Divya, research volunteer in the lab wins Emergent Scholarship 2021. Divya is an undergrad from UAB SciTech HONORS program. She has worked on several research projects in the lab, including depression effects on heart disease, diabetes effect on cardiomyocyte etc and has co-authored a peer-reviewed manuscript (Front. Cell Dev. Biol., 03 December 2019| https://doi.org/10.3389/fcell.2019.00315).
Clinical studies have shown a strong association between depression and risk for heart disease. However, the mechanisms are yet to be understood. Our recent study has revealed cardiac glycosaminoglycans and structural alterations during chronic stress-induced depression-like behavior in mice. The study is published in peer-reviewed American Journal of Physiology-Heart and Circulatory Physiology. Link for the full article: https://doi.org/10.1152/ajpheart.00635.2020
Our next step is to identify molecular signatures that mediate cardiac pathology during mental disorder. Research investigations are underway in our lab to study their role in causing heart disease and hopefully potential treatment strategies.
John Henderson, PhD Student in the lab, successfully defended his dissertation. The study investigates miRNA regulation of anticancer drug-induced cardiac pathology. Congratulations to John for achieving this important milestone.
Research Intern, Mr. David successfully completes 8-weeks UAB-Center for Community OutReach Development (CORD) Summer Science Program. David’s research work is titled “Effect of hyperglycemia on macrophage-derived exosomes and its impact on cardiac fibroblast”. Congratulations!
Dr. Mallikarjun Patil co-mentored David. Thanks to his effort!
Dr. Darukeshwara Joladarashi receives postdoctoral research fellowship award from American Heart Association. The fellowship will support his research work from July 2016- Jun 2018. His project is focused on studying the role of serine threonine kinase 35 in diabetic heart disease.
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