microRNA-377 Signaling Modulates Anticancer Drug-Induced Cardiotoxicity in Mice
John Henderson, Praveen K. Dubey, Mallikarjun Patil, Sarojini Singh, Shubham Dubey, Rajasekaran Namakkal Soorappan, Ramaswamy Kannappan, Palaniappan Sethu, Gangjian Qin, Jianyi Zhang, Krishnamurthy P.
Front. Cardiovasc. Med., 16 August 2021 | https://doi.org/10.3389/fcvm.2021.737826

Myofibroblast-Derived Exosome Induce Cardiac Endothelial Cell Dysfunction
Ranjan P, Kumari R, Goswami SK, Li J, Pal H, Suleiman Z, Cheng Z, Krishnamurthy P, Kishore R, Verma SK.
Front Cardiovasc Med. 2021 Apr;8:676267. doi: 10.3389/fcvm.2021.676267. eCollection 2021. PMID: 33969024.

Cardiac glycosaminoglycans and structural alterations during chronic stress-induced depression-like behavior in mice
Luong H, Singh S, Patil M, Krishnamurthy P.
Am J Physiol Heart Circ Physiol. 2021 Apr 9. doi: 10.1152/ajpheart.00635.2020. PMID: 33834865.

IL-10 provides cardioprotection in diabetic myocardial infarction via upregulation of Heme clearance pathways
Gupta R, Liu L, Zhang X, Fan X, Krishnamurthy P, Verma S, Tongers J, Misener S, Ashcherkin N, Sun H, Tian J, Kishore R.
JCI Insight. 2020 Sep 3;5(17):133050. doi: 10.1172/jci.insight.133050. PMID: 32879134.

Targeting Exosome-associated Human antigen R attenuates fibrosis and inflammation in diabetic heart.
Govindappa PM, Patil M, Garikipati VNS, Verma SK, Saheera S, Narasimhan G, Zhu W, Kishore R, Zhang J, Krishnamurthy P.
FASEB J. 2020 Feb;34(2):2238-2251. doi: 10.1096/fj.201901995R.

Myocardial protection by nanomaterials formulated with CHIR99021 and FGF1
Fan C, Oduk Y, Zhao M, Lou X, Tang Y, Pretorius D, Valarmathi MT, Walcott GP, Yang J, Menasche P, Krishnamurthy P, Zhu W, Zhang J.
JCI Insight. 2020 Jun 18;5(12):132796. doi: 10.1172/jci.insight.132796. PMID: 32453715.

Cardiovascular Changes Associated with Hypertensive Heart Disease and Aging
Saheera S, Krishnamurthy P.
Cell Transplant. 2020 Jan-Dec;29:963689720920830. doi: 10.1177/0963689720920830.

S100 family proteins in inflammation and beyond.
Sreejit G, Flynn MC, Patil M, Krishnamurthy P, Murphy AJ, Nagareddy PR.
Adv Clin Chem. 2020;98:173-231. doi: 10.1016/bs.acc.2020.02.006. Epub 2020 Apr 17.PMID: 32564786.

DNA Damage-Free iPS Cells Exhibit Potential to Yield Competent Cardiomyocytes.
Miller JM, Mardhekar NM, Pretorius D, Krishnamurthy P, Rajasekaran NS, Zhang J, Kannappan R.
Am J Physiol Heart Circ Physiol. 2020 Feb 14. doi: 10.1152/ajpheart.00658.2019.

The Art of Intercellular Wireless Communications: Exosomes in Heart Disease and Therapy.
Patil M, Henderson J, Luong H, Annamalai D, Sreejit G, Krishnamurthy P.
Frontiers in Cell and Developmental Biology 2019 (7), 315. Dec 3. https://doi.org/10.3389/fcell.2019.00315.

OBG-like ATPase 1 inhibition attenuates angiotensin II-induced hypertrophic response in human ventricular myocytes via GSK-3beta/beta-catenin signaling.
Narasimhan G, Henderson J, Luong HT, Rajasekaran NS, Qin G, Zhang J, Krishnamurthy P.
Clin Exp Pharmacol Physiol. 2019 May 7. doi: 10.1111/1440-1681.13101.

Sam68 impedes the recovery of arterial injury by augmenting inflammatory response.
Han S, Xu S, Zhou J, Qiao A, Boriboun C, Ma W, Li H, Biyashev D, Yang L, Zhang E, Liu Q, Jiang S, Zhao TC, Krishnamurthy P et al.
J Mol Cell Cardiol. 2019 Dec;137:82-92. doi: 10.1016/j.yjmcc.2019.10.003. Epub 2019 Oct 19.

Cardiomyocytes from CCND2-overexpressing human induced-pluripotent stem cells repopulate the myocardial scar in mice: A 6-month study.
Fan C, Fast VG, Tang Y, Zhao M, Turner JF, Krishnamurthy P et al.
J Mol Cell Cardiol. 2019;137:25–33. doi:10.1016/j.yjmcc.2019.09.011.

Exercise Mediated Nrf2 Signaling Protects the Myocardium From Isoproterenol-Induced Pathological Remodeling.
Shanmugam G, Challa AK, Devarajan A, Athmanathan B, Litovsky SH, Krishnamurthy P et al.
Front Cardiovasc Med. 2019;6:68;. doi: 10.3389/fcvm.2019.00068. PubMed PMID: 31245386.

Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure.
Berry JL, Zhu W, Tang YL, Krishnamurthy P, et al.
Circ Res. 2019 Jan 4;124(1):161-169. doi: 10.1161/CIRCRESAHA.118.314216.

Assessment of MiRNA Regulation of Endothelial Progenitor Cell Mediated Angiogenesis.
Joladarashi D, Krishnamurthy P.
Methods Mol Biol. 2017;1553:305-314. doi: 10.1007/978-1-4939-6756-8_24.

Therapeutic inhibition of miR-375 attenuates post-myocardial infarction inflammatory response and left ventricular dysfunction via PDK-1-AKT signalling axis.
Garikipati VNS, Verma SK, Jolardarashi D, Cheng Z, Ibetti J, Cimini M, Tang Y, Khan M, Yue Y, Benedict C, Nickoloff E, Truongcao MM, Gao E, Krishnamurthy P, Goukassian DA, Koch WJ, Kishore R.
Cardiovasc Res. 2017 Jul 1;113(8):938-949. doi: 10.1093/cvr/cvx052.

Interleukin-10 Inhibits Bone Marrow Fibroblast Progenitor Cell-Mediated Cardiac Fibrosis in Pressure-Overloaded Myocardium.
Verma SK, Garikipati VNS, Krishnamurthy P, Schumacher SM, Grisanti LA, Cimini M, Cheng Z, Khan M, Yue Y, Benedict C, Truongcao MM, Rabinowitz JE, Goukassian DA, Tilley D, Koch WJ, Kishore R.
Circulation. 2017 Sep 5;136(10):940-953. doi: 10.1161/CIRCULATIONAHA.117.027889.

MicroRNA-126 overexpression rescues diabetes-induced impairment in efferocytosis of apoptotic cardiomyocytes.
Suresh Babu S, Thandavarayan RA, Joladarashi D, Jeyabal P, Krishnamurthy S, Bhimaraj A, Youker KA, Krishnamurthy P.
Sci Rep. 2016 Nov 9;6:36207. doi: 10.1038/srep36207.

MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1.
Jeyabal P, Thandavarayan RA, Joladarashi D, Babu SS, Krishnamurthy S, Bhimaraj A, Youker KA, Kishore R, Krishnamurthy P.
Biochem Biophys Res Commun., 2016 Feb 17. pii: S0006-291X(16)30254-6. doi: 10.1016/j.bbrc.2016.02.065.

Enhanced Cardiac Regenerative Ability of Stem Cells After Ischemia-Reperfusion Injury: Role of Human CD34+ Cells Deficient in MicroRNA-377.
Darukeshwara J, Garikipati VN, Thandavarayan RA, Verma SK, Mackie AR, Khan M, Gumpert AM, Bhimaraj A, Youker KA, Uribe C, Suresh Babu S, Jeyabal P, Kishore R, Krishnamurthy P.
J Am Coll Cardiol. 2015 Nov 17;66(20):2214-26. doi: 10.1016/j.jacc.2015.09.009; won HMRI President’s Award for Transformational Excellence-Peer Reviewed Publication

Vascular Aging: Implications for Cardiovascular Disease and Therapy.
Ghebre YT, Yakubov E, Wong WT, Krishnamurthy P, Sayed N, Sikora AG, Bonnen MD
Transl Med (Sunnyvale) 2016; 6: 183. doi:10.4172/2161-1025.1000183 Epub 2016 Apr 18.

Alcohol Toxicity in Diabetes and Its Complications: A Double Trouble?
Munukutla S, Pan G, Deshpande M, Thandavarayan RA, Krishnamurthy P, Palaniyandi SS.
Alcohol Clin Exp Res. 2016 Apr;40(4):686-97. doi: 10.1111/acer.13008. Epub 2016 Mar 25. Review.

Role of MAPK mediated endoplasmic reticulum signaling in the heart during aging in senescence-accelerated prone mice.
Sreedhar R, Giridharan VV, Arumugam S, Karuppagounder V, Krishnamurthy P, Konishi T, Watanabe K, Thandavarayan RA.
Biofactors. 2016 Apr 18. doi: 10.1002/biof.1280.

Modulation of Macrophage Polarization and HMGB1-TLR2/TLR4 Cascade Plays a Crucial Role for Cardiac Remodeling in Senescence-Accelerated Prone Mice.
Karuppagounder V, Giridharan VV, Arumugam S, Sreedhar R, Palaniyandi SS, Krishnamurthy P, Quevedo J, Watanabe K, Konishi T, Thandavarayan RA.
Trends Cardiovasc Med. 2016 Mar 15. pii: S1050-1738(16)00083-9. doi: 10.1016/j.tcm.2016.03.007.

Editorial Commentary: miRNA a tiny genetic tool: Key to the puzzle of cardiovascular disease.
Giridharan VV, Quevedo J, Krishnamurthy P, Thandavarayan RA.
Trends Cardiovasc Med. 2016 Mar 15. pii: S1050-1738(16)00083-9. doi: 10.1016/j.tcm.2016.03.007.

Naringenin ameliorates skin inflammation and accelerates phenotypic reprogramming from M1 to M2 macrophage polarization in atopic dermatitis NC/Nga mouse model.
Karuppagounder V, Arumugam S, Thandavarayan RA, Sreedhar R, Giridharan V, Pitchaimani V, Afrin R, Harima M, Krishnamurthy P, Suzuki K, Nakamura M, Ueno K, Watanabe, K.
Exp Dermatol. 2016 Feb 2. doi: 10.1111/exd.12962.

Interleukin-10 Inhibits Chronic Angiotensin II-induced Pathological Autophagy.
Kishore R, Krishnamurthy P, Garikipati VN, Benedict C, Nickoloff E, Khan M, Johnson J, Gumpert AM, Koch W, Verma SK.
J Mol Cell Cardiol. 2015 Nov 6. pii: S0022-2828(15)30108-5. doi: 10.1016/j.yjmcc.2015.11.004.

Depletion of cardiac 14-3-3-eta protein adversely influences pathologic cardiac remodeling during myocardial infarction after coronary artery ligation in mice.
Sreedhar R, Arumugam S, Thandavarayan RA, Giridharan VV, Karuppagounder V, Pitchaimani V, Afrin R, Harima M, Nakamura M, Suzuki K, Gurusamy N, Krishnamurthy P, Watanabe K.
Int J Cardiol. 2016 Jan 1;202:146-53. doi: 10.1016/j.ijcard.2015.08.142.

IL-10 Accelerates Re-Endothelialization and Inhibits Post-Injury Intimal Hyperplasia following Carotid Artery Denudation.
Verma SK, Garikipati VN, Krishnamurthy P, Khan M, Thorne T, Qin G, Losordo DW, Kishore R.
PLoS One. 2016 Jan 25;11(1):e0147615. doi: 10.1371/journal.pone.0147615.

Schisandrin B Ameliorates ICV-Infused Amyloid β Induced Oxidative stress and Neuronal Dysfunction through Inhibiting RAGE/NF-κB/MAPK and Up-regulating HSP/beclin Expression.
Giridharan VV, Thandavarayan RA, Mizuno M, Arumugam S, Nawa H, Suzuki K, Ko KM, Krishnamurthy P, Watanabe K, Konishi T.
PLoS One. 2015 Nov 10;10(11):e0142483. doi: 10.1371/journal.pone.0142483.

Negative Regulation of miR-375 by Interleukin-10 Enhances Bone Marrow derived Progenitor Cell-mediated Myocardial Repair and Function after Myocardial Infarction.
Srikanth GVN, Krishnamurthy P, Verma SK, Khan M, Abramova TV, Mackie AR, Ramirez V, Qin G, Benedict C, Nickoloff E, Johnson J, Yuan A, Gao E, Losordo DW, Houser SR, Koch WJ, Kishore R.
Stem Cells, 2015. DOI: 10.1002/stem.2121

Angiotensin receptor blockers: Focus on cardiac and renal injury.
Arumugam S, Sreedhar R, Thandavarayan RA, Karuppagounder V, Krishnamurthy P, Suzuki K, Nakamura M, Watanabe K.
Trends Cardiovasc Med. 2015 Jun 15. pii: S1050-1738(15)00170-X. doi: 10.1016/j.tcm.2015.06.004. [Epub ahead of print]

Sirtuin-6 deficiency exacerbates diabetes induced impairment of wound healing.
Thandavarayan RA, Garikipati VN, Darukeshwara J, Suresh Babu S, Jeyabal P, Verma SK, Mackie AR, Khan M, Arumugam S, Watanabe K, Kishore R, Krishnamurthy P.
Exp Dermatol. 2015 May 23. doi: 10.1111/exd.12762. [Epub ahead of print].

Embryonic Stem Cell-Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial Infarction.
Khan M, Nickoloff E, Abramova T, Johnson J, Verma SK, Krishnamurthy P, Mackie AR, Vaughan E, Garikipati VN, Benedict CL, Ramirez V, Lambers E, Ito A, Gao E, Misener S, Qin G, Luongo TS, Elrod JW, Houser SR, Koch WJ, Kishore R.
Circ Res. 2015 Apr 22. pii: CIRCRESAHA.115.305990. [Epub ahead of print].

Enhancer-associated long noncoding RNAs: A novel frontier with new perception in cardiac regeneration.
Jeyabal P, Thandavarayan RA, Babu SS, Krishnamurthy P.
Editorial Commentary. Trends Cardiovasc Med. 2015 Feb 23. pii: S1050-1738(15)00061-4. doi: 10.1016/j.tcm.2015.02.010.

Schisandrin B Prevents Doxorubicin Induced Cardiac Dysfunction by Modulation of DNA Damage, Oxidative Stress and Inflammation through Inhibition of MAPK/p53 Signaling.
Thandavarayan RA, Giridharan VV, Arumugam S, Suzuki K, Ko KM, Krishnamurthy P, Watanabe K, Konishi T.
PLoS One. 2015 Mar 5;10(3):e0119214. doi: 10.1371/journal.pone.0119214.

RNA stabilizing proteins as molecular targets in cardiovascular pathologies.
Sahana S Babu, Darukeshwara J, Jeyabal P, Thandavarayan RA, Krishnamurthy P.
Trends Cardiovasc Med. 2015 Feb 20. pii: S1050-1738(15)00057-2. doi: 10.1016/j.tcm.2015.02.006.

Small engine, big power: microRNAs as regulators of cardiac diseases and regeneration.
Darukeshwara J, Thandavarayan RA, Sahana S Babu, Krishnamurthy P.
International Journal of Molecular Sciences. 2014; 15(9):15891-15911.doi:10.3390/ijms150915891

The emerging role of microRNAs in pathogenesis of diabetic cardiomyopathy.
Thandavarayan RA, Darukeshwara J, Krishnamurthy P.
Experimental and Clinical Cardiology. 2014; 20(8):4525-4534.

Alcohol consumption negates estrogen-mediated myocardial repair in ovariectomized mice by inhibiting endothelial progenitor cell mobilization and function
Mackie AR, Krishnamurthy P, Verma SK, Thorne T, Ramirez V, Qin G, Abramova T, Hamada H, Losordo DW, Kishore R.
Journal of Biological Chemistry. 2013 Jun 21;288(25):18022-18034.doi:10.1074/jbc.M113.468009.
PMID:23645678   ISSN: 00219258

Bone Marrow Progenitor Cell Therapy-Mediated Paracrine Regulation of Cardiac miRNA-155 Modulates Fibrotic Response in Diabetic Hearts
Kishore R, Verma SK, Mackie AR, Vaughan EE, Abramova TV, Aiko I, Krishnamurthy P.
PLOS ONE. 2013 Apr;8(4):doi:10.1371/journal.pone.0060161.
PMID:22915496   ISSN: 19326203

Histone deacetylase 1 deficiency impairs differentiation and electrophysiological properties of cardiomyocytes derived from induced pluripotent cells
Hoxha E, Lambers E, Xie H, De Andrade A, Krishnamurthy P, Wasserstrom JA, Ramirez V, Thal M, Verma SK, Soares MB, Kishore R.
Stem Cells. 2012 Nov;30(11):2412-2422.doi:10.1002/stem.1209.
PMID:22915496   PMCID: PMC3479375   ISSN: 10665099

Elucidation of a Novel Pathway through Which HDAC1 Controls Cardiomyocyte Differentiation through Expression of SOX-17 and BMP2
Hoxha E, Lambers E, Wasserstrom JA, Mackie A, Ramirez V, Abramova T, Verma SK, Krishnamurthy P, Kishore R.
PLoS ONE. 2012 Sep 12;7(9):doi:10.1371/journal.pone.0045046.
PMID:22984607   PMCID: PMC3440419   ISSN: 19326203

Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-κB
Verma SK, Krishnamurthy P, Barefield D, Singh N, Gupta R, Lambers E, Thal M, MacKie A, Hoxha E, Ramirez V, Qin G, Sadayappan S, Ghosh AK, Kishore R.
Circulation. 2012 Jul 24;126(4):418-429.doi:10.1161/CIRCULATIONAHA.112.112185.
PMID:22705886   PMCID: PMC3422741   ISSN: 00097322

Enhanced angiogenic and cardiomyocyte differentiation capacity of epigenetically reprogrammed mouse and human endothelial progenitor cells augments their efficacy for ischemic myocardial repair
Thal MA, Krishnamurthy P, MacKie AR, Hoxha E, Lambers E, Verma S, Ramirez V, Qin G, Losordo DW, Kishore R.
Circulation Research. 2012 Jul 6;111(2):180-190.doi:10.1161/CIRCRESAHA.112.270462.
PMID:22589372   PMCID: PMC3406600   ISSN: 00097330

Interleukin-10 deficiency impairs bone marrow-derived endothelial progenitor cell survival and function in ischemic myocardium
Krishnamurthy P, Thal M, Verma S, Hoxha E, Lambers E, Ramirez V, Qin G, Losordo D, Kishore R.
Circulation Research. 2011 Nov 11;109(11):1280-1289.doi:10.1161/CIRCRESAHA.111.248369.
PMID:21959218   PMCID: PMC3235675   ISSN: 00097330

Myocardial knockdown of mRNA-stabilizing protein HuR attenuates post-MI inflammatory response and left ventricular dysfunction in IL-10-null mice
Krishnamurthy P, Lambers E, Verma S, Thorne T, Qin G, Losordo DW, Kishore R.
FASEB Journal. 2010 Jul;24(7):2484-2494.doi:10.1096/fj.09-149815.
PMID:20219984   PMCID: PMC2887267   ISSN: 08926638

Career moves: Induced pluripotent cells from human aortic smooth muscle cells can efficiently redifferentiate into parental phenotype
Kishore R, Krishnamurthy P, Losordo DW.
Circulation Research. 2010 Jan;106(1):7-9.doi:10.1161/CIRCRESAHA.109.210351.
PMID:20056938   PMCID: PMC3132886   ISSN: 00097330

IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR
Krishnamurthy P, Rajasingh J, Lambers E, Qin G, Losordo DW, Kishore R.
Circulation Research. 2009 Jan 30;104(2):e9-e18.doi:10.1161/CIRCRESAHA.108.188243.
PMID:19096025   PMCID: PMC2774810   ISSN: 00097330

Inhibition of matrix metalloproteinases improves left ventricular function in mice lacking osteopontin after myocardial infarction
Krishnamurthy P, Peterson JT, Subramanian V, Singh M, Singh K.
Molecular and Cellular Biochemistry. 2009 Jan;322(1-2):53-62.doi:10.1007/s11010-008-9939-6.
PMID:18979185   PMCID: PMC2711544   ISSN: 03008177

Cell-free embryonic stem cell extract-mediated derivation of multipotent stem cells from NIH3T3 fibroblasts for functional and anatomical ischemic tissue repair
Rajasingh J, Lambers E, Hamada H, Bord E, Thorne T, Goukassian I, Krishnamurthy P, Rosen KM, Ahluwalia D, Zhu Y, Qin G, Losordo DW, Kishore R.
Circulation Research. 2008 Jun 6;102(11):e107-e117.doi:10.1161/CIRCRESAHA.108.176115.
PMID:18483406   PMCID: PMC2435186   ISSN: 00097330

β1 integrins modulate β-adrenergic receptor-stimulated cardiac myocyte apoptosis and myocardial remodeling
Krishnamurthy P, Subramanian V, Singh M, Singh K.
Hypertension. 2007 Apr;49(4):865-872.doi:10.1161/01.HYP.0000258703.36986.13.
PMID:17283249   ISSN: 0194911X

Lack of osteopontin improves cardiac function in streptozotocin-induced diabetic mice
Subramanian V, Krishnamurthy P, Singh K, Singh M.
American Journal of Physiology – Heart and Circulatory Physiology. 2007 Jan;292(1):H673-H683.doi:10.1152/ajpheart.00569.2006.
PMID:16980342   ISSN: 03636135

Behavioural and neurotoxic effects in Wistar rats induced by low doses of ochratoxin A
Krishnamurthy P, Sharma AK, Dwivedi P, Tandan SK.
Toxicology International. 2006 Dec;13(2):93-98.
ISSN: 09716580

Expression of the cytoplasmic domain of β1 integrin induces apoptosis in adult rat ventricular myocytes (ARVM) via the involvement of caspase-8 and mitochondrial death pathway
Menon B, Krishnamurthy P, Kaverina E, Johnson JN, Ross RS, Singh M, Singh K.
Basic Research in Cardiology. 2006 Nov;101(6):485-493.doi:10.1007/s00395-006-0602-7.
PMID:16783488   ISSN: 03008428

Deficiency of β1 integrins results in increased myocardial dysfunction after myocardial infarction
Krishnamurthy P, Subramanian V, Singh M, Singh K.
Heart. 2006 Sep;92(9):1309-1315.doi:10.1136/hrt.2005.071001.
PMID:16547211   PMCID: PMC1861145   ISSN: 1355603

Pathogenicity of Pasteurella multocida A:1 in experimentally infected chickens and chicken embryos
Shivachandra SB, Kumar AA, Singh SD, Shivakumar BM, Prasanna K.
Indian Journal of Animal Sciences. 2005 Apr;75(4):411-414.

Correlation of clinicopathological and microbiological studies in experimental fowl typhoid and pullorum disease in chicken
Prasanna K, Paliwal OP, Verma JC.
Indian Journal of Animal Sciences. 2003 Jun;73(6):627-629.

Immunocytochemical detection of Salmonella Gallinarum and Salmonella Pullorum in experimentally infected chickens
Prasanna K, Paliwal OP, Kumar R, Tripathi BN.
Indian Journal of Animal Sciences. 2002 Feb;72(2):113-116.