Doxorubicin (DOX, an anthracycline) is a widely used chemotherapy agent against various forms of cancer. However, it is known to induce dose-dependent cardiotoxicity that leads to adverse cardiac complications. Our lab investigates the role of microRNA-377 in anticancer drug-induced cardiotoxicity in mice. Read the full article at: https://www.frontiersin.org/articles/10.3389/fcvm.2021.737826/full
The work is supported through grants from National Institutes of Health (NIH) and American Heart Association.
Details of the research article:
microRNA-377 Signaling Modulates Anticancer Drug-Induced Cardiotoxicity in Mice
John Henderson, Praveen K. Dubey, Mallikarjun Patil, Sarojini Singh, Shubham Dubey, Rajasekaran Namakkal Soorappan, Ramaswamy Kannappan, Palaniappan Sethu, Gangjian Qin, Jianyi Zhang, Krishnamurthy P.
Front. Cardiovasc. Med., 16 August 2021 | https://doi.org/10.3389/fcvm.2021.737826