Postdoctoral Positions in Vaccine Development and Systems Immunology Available Immediately 03/29/2022

Center for Vaccine Development and Global Health (CVD), Immunology Group,
University of Maryland School of Medicine.

We are seeking postdoctoral fellows to work on immunological studies directed at understanding immune responses and uncovering immunological correlates of protection following immunization and infection in humans with the long-term goal of accelerating the development of novel vaccines. Studies will include exploration of the mechanisms operative in the generation of systemic and mucosal immunity in children, young adults and the elderly and their relationship to the gut microbiota. These studies will involve participants immunized with licensed or investigational attenuated and subunit vaccines, as well as volunteers challenged with wild-type organisms. Studies will involve the use of advanced technologies and instrumentation such as high-parameter flow cytometry and mass cytometry (50+ parameters/cell) with a focus on complex data analyses, as well as the performance of a variety of molecular biology and immunological techniques depending on the research questions being addressed. These include, among others, functional assays (e.g., cell purification, proliferation, cytotoxic T cell activity, Elispot, regulatory T cell activity, identification of T cell epitopes, B cell maturation and function), multiplexed cytokines/chemokines/biomarker determinations, bulk transcriptomics on heterogeneous populations and sorted cell subsets, single cell transcriptomics (scRNA-seq), CITE-seq, scTCR-seq, scBCR-seq, epigenetic landscape determinations, and role of microRNAs (miRNA) in the regulation of immunity.

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Third Round of Pilot Grant Awardees Announced

The CCHI IOFM Core funded seven applications submitted in response to our RFA released September 2, 2021. The CCHI Steering Committee sought applications from CCHI centers to capitalize on emerging opportunities and encourage multi-center, multi-disciplinary collaborations. The immediate objective of the CCHI is to support mechanistic and hypothesis-testing studies to understand human immunity applicable to the biodefense effort (i.e. innate, adaptive and mucosal immune responses to infection, vaccination and adjuvants). Studies on immune-mediated diseases (e.g. airway allergy, food allergy, autoimmunity, organ transplant rejection) and basic human immunology are also of interest, as these data will provide a more comprehensive understanding of the human immune system.  Special consideration is provided to investigators from groups shown to be underrepresented in the represented in the biomedical workforce (NIH’s Interest in Diversity, NOT-OD-20-031), Early Stage Investigators/New Investigators (ESI/NI, please see NIH Next Generation Research Initiative Policies), and investigators who are relatively new to human immunology research.

Gabriel Victora, PhD, MSc from Rockefeller University applied from the Rockefeller University CCHI U19 Center (Ravetch, PD/PI). Project is entitled “Reactivation and secondary hypermutation of memory B in humans following hepatitis B immunization”

Debattama Sen, PhD from Massachusetts General Hospital; MPI, George Lauer, MD, PhD applied from the Massachusetts General Hospital/University of Pennsylvania CCHI U19 Center (Chung and Wherry, PD/PIs). Project is entitled “Dissecting exhausted CD8+ T cell fate and function using epigenome editing”

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Postdoctoral Positions in Vaccine Development

Job description: Postdoctoral Positions in Vaccine Development. November 18, 2021. Center for Vaccine Development and Global Health (CVD), Immunology Group, University of Maryland School of Medicine. Available immediately. 

The CVD involves scientists and physicians working in all phases of vaccine development. The CVD has earned an international reputation for genetically engineering and testing vaccines against a wide variety of enteric and other infections. Based in the School of Medicine at the University of Maryland, Baltimore, the CVD was established in the 70’s as one of the first facilities to evaluate vaccines in community volunteers. It is one of only a handful of vaccine centers in the world engaged in the full range of vaccinology: from basic science through vaccine development, immunological studies, clinical evaluation, and field studies. 

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Second Round of Pilot Grant Awardees Announced

The CCHI IOFM Core funded six applications submitted in response to our RFA released August 31, 2020. The CCHI Steering Committee sought applications from CCHI centers to capitalize on emerging opportunities and encourage multi-center, multi-disciplinary collaborations. The immediate objective of the CCHI is to support mechanistic and hypothesis-testing studies to understand human immunity applicable to the biodefense effort (i.e. innate, adaptive and mucosal immune responses to infection, vaccination and adjuvants). Studies on immune-mediated diseases (e.g. airway allergy, food allergy, autoimmunity, organ transplant rejection) are also of interest, as these data will provide a more comprehensive understanding of the human immune system.

Sean Brady, PhD from Rockefeller University applied from the Rockefeller University CCHI U19 Center (Ravetch, PD/PI).  Project is entitled “Human-microbial-lectins regulate the mucosal immune system”

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First Round of Pilot Grant Awardees Announced

person holding petri dish with colorful content toward camera

The CCHI IOFM Core funded ten applications submitted in response to our RFA released August 26, 2019.  The CCHI Steering Committee sought applications from CCHI centers to capitalize on emerging opportunities and encourage multi-center, multi-disciplinary collaborations. The immediate objective of the CCHI is to support mechanistic and hypothesis-testing studies to understand human immunity applicable to the biodefense effort (i.e. innate, adaptive and mucosal immune responses to infection, vaccination and adjuvants). Studies on immune-mediated diseases (e.g. airway allergy, food allergy, autoimmunity, organ transplant rejection) are also of interest, as these data will provide a more comprehensive understanding of the human immune system.

Stephanie Boisson-Dupuis, PhD from Rockefeller University applied from the Rockefeller University CCHI U19 Center (Ravetch, PD/PI).  Project is entitled “Inherited human PD-1 deficiency”

Stylianos Bournazos, PhD from Rockefeller University applied from the Rockefeller University CCHI U19 Center (Ravetch, PD/PI).  Project is entitled “Modulating the antibody response to vaccination through targeting the CD40 axis”

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Fourth Cycle of Cooperative Centers on Human Immunology Funded

The Cooperative Centers on Human Immunology (CCHI) were awarded in response to RFA-AI-17-040 to support studies that will advance our understanding of the mechanisms regulating human immune response.  The CCHI U19 mechanism supports mechanistic and hypothesis-testing studies to understand human immunity applicable to the biodefense effort; i.e. innate, adaptive and mucosal immune responses to infection, vaccination and adjuvants. Studies on immune-mediated diseases (e.g. airway allergy, food allergy, autoimmunity, organ transplant rejection) are also of interest, as these data will provide a more comprehensive understanding of the human immune system.

The program supports the centralized infrastructure needed to promote and coordinate multi-disciplinary research in human immunology. Additional objectives are to promote public access to CCHI-supported data and metadata through public portals such as ImmPort, and develop new technologies to support human immunology research.

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