First Round of Pilot Grant Awardees Announced

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The CCHI IOFM Core funded ten applications submitted in response to our RFA released August 26, 2019.  The CCHI Steering Committee sought applications from CCHI centers to capitalize on emerging opportunities and encourage multi-center, multi-disciplinary collaborations. The immediate objective of the CCHI is to support mechanistic and hypothesis-testing studies to understand human immunity applicable to the biodefense effort (i.e. innate, adaptive and mucosal immune responses to infection, vaccination and adjuvants). Studies on immune-mediated diseases (e.g. airway allergy, food allergy, autoimmunity, organ transplant rejection) are also of interest, as these data will provide a more comprehensive understanding of the human immune system.

Stephanie Boisson-Dupuis, PhD from Rockefeller University applied from the Rockefeller University CCHI U19 Center (Ravetch, PD/PI).  Project is entitled “Inherited human PD-1 deficiency”

Stylianos Bournazos, PhD from Rockefeller University applied from the Rockefeller University CCHI U19 Center (Ravetch, PD/PI).  Project is entitled “Modulating the antibody response to vaccination through targeting the CD40 axis”

Shirit Einav, MD from Stanford University applied from the Stanford University CCHI U19 Center (Davis, PD/PI).  Project is entitled “Deciphering the pathogenesis of severe dengue in natural infection in children via single-cell approaches”

William Hildebrand, PhD, MA from the University of Oklahoma Health Sciences Center applied from the Oklahoma Medical Research Foundation CCHI U19 Center (Coggeshall, PD/PI).  The Core is entitled “HLA Typing Core”

Kate Jeffrey, PhD from Massachusetts General Hospital applied from the Massachusetts General Hospital/University of Pennsylvania CCHI U19 Center (Chung and Wherry, PD/PIs).  Project is entitled “Examination of the Epigenome in Single and Low Number Human Immune Cells”

Murali Krishna Kaja, PhD from Emory University applied from the Emory University CCHI U19 Center (Ahmed, PD/PI). Project is entitled “Characterizing dengue specific IgG subclass antibody responses and Fc glycosylation changes during primary and secondary dengue infections in India”

Rodney King, PhD from the University of Alabama at Birmingham applied from the University of Alabama at Birmingham CCHI U19 Center (Lund, PD/PI).  Project is entitled “The influence of isotype CH1 on antigen binding”

Holden Maecker, PhD from Stanford University applied from the Stanford University CCHI U19 Center (Davis, PD/PI).  Course is entitled “CyTOF Immune Monitoring Course”

Anoma Nellore, MD from the University of Alabama at Birmingham applied from the University of Alabama at Birmingham CCHI U19 Center (Lund, PD/PI).  Project is entitled “Characterization of Mucosal and Circulating HA-specific B cells after LAIV”

Catherine Wu, MD from the Dana-Farber Cancer Institute applied from the Massachusetts General Hospital/University of Pennsylvania CCHI U19 Center (Chung and Wherry, PD/PIs).  Project is entitled “Tissue localization of virus-specific T cells by spatial sequencing technologies”

Fourth Cycle of Cooperative Centers on Human Immunology Funded

The Cooperative Centers on Human Immunology (CCHI) were awarded in response to RFA-AI-17-040 to support studies that will advance our understanding of the mechanisms regulating human immune response.  The CCHI U19 mechanism supports mechanistic and hypothesis-testing studies to understand human immunity applicable to the biodefense effort; i.e. innate, adaptive and mucosal immune responses to infection, vaccination and adjuvants. Studies on immune-mediated diseases (e.g. airway allergy, food allergy, autoimmunity, organ transplant rejection) are also of interest, as these data will provide a more comprehensive understanding of the human immune system.

The program supports the centralized infrastructure needed to promote and coordinate multi-disciplinary research in human immunology. Additional objectives are to promote public access to CCHI-supported data and metadata through public portals such as ImmPort, and develop new technologies to support human immunology research.

This current cycle represents the 4th cycle of funding for the U19 human immunology funding mechanism.  Several of our current CCHI center members are repeat awardees.  Emory University, Oklahoma Medical Research Foundation and Stanford University have begun their 4th cycle of funding (since 2003-2004); Massachusetts General Hospital is on its 3rd cycle (since 2009); and Rockefeller University is beginning its 2nd cycle of funding (since 2014).  New to the group are Jackson Laboratory, La Jolla Institute for Allergy and Immunology, and the University of Alabama at Birmingham, which is also hosting the Infrastructure and Opportunity Fund Management Core.