The Cooperative Centers on Human Immunology (CCHI) have announced release of RFA-AI-22-069 to support interdisciplinary team science that will provide foundational information on human immune system function to support translation of immunology research into clinical benefits. The CCHI U19 mechanism supports mechanistic and hypothesis-testing studies to discover novel molecules, mechanisms, or regulatory pathways governing function of the human immune system in both healthy and vulnerable populations (i.e., across lifespan, organ/tissue transplant recipients, pregnant women). Studies of interest include immunity related to prevention or treatment of infectious diseases, immune-mediated pathogenesis/sequelae associated with infectious disease, and/or immune-mediated diseases. This FOA also supports technology development to advance studies of the human immune system. Applications are due on or before April 7, 2023.