The CCHI IOFM Core funded seven applications submitted in response to our RFA released September 2, 2021. The CCHI Steering Committee sought applications from CCHI centers to capitalize on emerging opportunities and encourage multi-center, multi-disciplinary collaborations. The immediate objective of the CCHI is to support mechanistic and hypothesis-testing studies to understand human immunity applicable to the biodefense effort (i.e. innate, adaptive and mucosal immune responses to infection, vaccination and adjuvants). Studies on immune-mediated diseases (e.g. airway allergy, food allergy, autoimmunity, organ transplant rejection) and basic human immunology are also of interest, as these data will provide a more comprehensive understanding of the human immune system. Special consideration is provided to investigators from groups shown to be underrepresented in the represented in the biomedical workforce (NIH’s Interest in Diversity, NOT-OD-20-031), Early Stage Investigators/New Investigators (ESI/NI, please see NIH Next Generation Research Initiative Policies), and investigators who are relatively new to human immunology research.
Gabriel Victora, PhD, MSc from Rockefeller University applied from the Rockefeller University CCHI U19 Center (Ravetch, PD/PI). Project is entitled “Reactivation and secondary hypermutation of memory B in humans following hepatitis B immunization”
Debattama Sen, PhD from Massachusetts General Hospital; MPI, George Lauer, MD, PhD applied from the Massachusetts General Hospital/University of Pennsylvania CCHI U19 Center (Chung and Wherry, PD/PIs). Project is entitled “Dissecting exhausted CD8+ T cell fate and function using epigenome editing”
Ansuman Satpathy, MD, PhD from Stanford University applied from the Stanford University CCHI U19 Center (Davis, PD/PI). Project is entitled “Massively-parallel single-cell multi-omics to chart human immune cell states in infection”
Anamika Patel, PhD from Emory University applied from the Emory University CCHI U19 Center (Ahmed PD/PI). Project is entitled “Structure-Function study of CoV-2 neutralizing antibodies from Indian population”
Selene Meza-Perez, PhD from the University of Alabama at Birmingham; MPI, Troy Randall, PhD applied from the University of Alabama at Birmingham CCHI U19 Center (Lund, PD/PI) Project is entitled “Role of microbiota-dependent arginine catabolism in tuning mTOR-dependent Treg function”
Sixto Leal, MD, PhD from the University of Alabama at Birmingham applied from the University of Alabama at Birmingham CCHI U19 Center (Lund, PD/PI). Project is entitled “The Impact of SARS-CoV-2 Immune Dysregulation on Antifungal Immunity”
William Hildebrand, PhD, MA from the University of Oklahoma Health Sciences Center applied from the Oklahoma Medical Research Foundation CCHI U19 Center (Coggeshall/Thompson, PD/PI). Project is entitled “HLA Typing Core for CCHI Investigators”