Antimicrobial resistance happens when germs like bacteria and fungi develop the ability to defeat the drugs designed to kill them. That means the germs are not killed and continue to grow. Resistant infections can be difficult, and sometimes impossible to treat. Multidrug-resistant organisms are bacteria’s that have become resistant to certain antibiotics, and these antibiotics can no longer be used to control or kill the bacteria. Antibiotics are important medicines. They help fight infections that are caused by bacteria. Bacteria that resist treatment with more than one antibiotic are called multidrug-resistant organisms (MDROs for short), (ct.gov,2023).
Examples of (MDROs), includes methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE) and certain gram-negative bacilli (GNB) which have important infection control implications that either have not been addressed or received only limited consideration (CDC,2015).
Below are recommended resources for hospitals and long-term care facilities on MDROs:
Infections from a rare extensively drug-resistant strain of Pseudomonas aeruginosa have been identified in 12 states (CA, CO, CT, FL, NJ, NY, NV, TX, UT, WA, WI). Most of the infections were from patients who reported using artificial tears. Patients reported more than 10 brands of artificial tears, but most patients reported using Ezricare Artificial Tears, an over-the-counter product. Patients who were infected have experienced permanent vision loss resulting from a cornea infection, hospitalization, and one death has been reported due to a systematic infection (CDC, 2023). The University of California at San Diego’s Center for Innovative Phage Applications and Therapeutics have identified a bacteriophage with activity against the outbreak strain. A minimum inhibitory concentration for aztreonam-avibactam has been identified, however, clinical breakpoints have not been established for antimicrobial combination.
For recommendations from the CDC for Healthcare Providers, Clinical Laboratories, and the Public, visit the link here.
Clinicians interested in phage as a potential treatment option should contact IPATH at firstname.lastname@example.org.
Susceptibility testing for this combination to inform clinical decision making is available through
CDC – refer to CDC Test Directory.
Centers for Disease Control and Prevention. (2023, February 1). Health Alert Network (HAN) – 00485. Centers for Disease Control and Prevention. Retrieved April 5, 2023, from https://emergency.cdc.gov/han/2023/han00485.asp
Candida auris is an emerging pathogen that results in nosocomial infections and is considered a serious global health problem. It was first observed as a novel Candida species in 2009 and has been isolated in 35 countries.
C. auris may cause invasive infections associated with high mortality. It is considered a multi-drug resistant species, having variable resistance patterns to many typical antifungal agents used to treat other Candida infections.
The CDC is concerned about C. auris for three main reasons:
It is often multidrug-resistant, meaning that it is resistant to multiple antifungal drugs commonly used to treat Candida infections. Some strains are resistant to all three available classes of antifungals.
It is difficult to identify with standard laboratory methods, and it can be misidentified in labs without specific technology. Misidentification may lead to inappropriate management.
It has caused outbreaks in healthcare settings. For this reason, it is important to quickly identify C. auris in a hospitalized patient so that healthcare facilities can take special precautions to stop its spread.
Multi-lingual fact sheets on Candida auris by the CDC: contains information on Candida auris.what we need to know, cases over time and global threat of the disease in languages such as English, Spanish, Vietnamese, Korean and Haitian – Candida auris: A multi-drug resistant pathogen
From early May 2022 to June 13, 2022 (the date of this podcast recording), over 1,300 confirmed cases of monkeypox have been reported across 31 countries that normally don’t see any cases of monkeypox. Occasionally, outbreaks have occurred outside Africa. But, in most instances, these cases were associated with international travel or contact with individuals or animals from endemic regions. Currently, the CDC and World Health Organization are tracking multiple reported cases and monitoring several person in counties without endemic monkeypox and with no known travel links to an endemic area.
In today’s podcast, we welcome back Dr. Rachael Lee, Associate Professor in the UAB Division of Infectious Diseases and UAB Health Epidemiologist to talk to us about monkeypox – what it is and if we should be worried?
The State of Alabama has had a lot of firsts; the first open-heart surgery in the Western Hemisphere was performed in Montgomery in 1902, in 1968 the first 911 call was placed from Haleyville, AL, and unfortunately in 2021 amid the ongoing COVID-19 pandemic Alabama identified their first case of a new Hepatitis outbreak among children under the age of 10. Children in Alabama began to fall ill with symptoms of Hepatitis, an inflammation of the liver that can cause jaundice, fever, fatigue, nausea, vomiting, joint pain, and more symptoms. Despite the mysterious onset and widespread unconnected cases under investigation doctors and other researchers are still trying to pin down the direct cause. The onset of symptoms has not been shown to be related to COVID-19 or its vaccinations, as once thought could be the case. Now, research points to the outbreak possibly being related to a new adenovirus strain. As of June 1, 2022, the outbreak and cause are still under investigation, with 246 cases under investigation of children under the age of ten showing symptoms of hepatitis with an unknown cause across 38 different states with 6 deaths since October 2021. Unfortunately, as is frequently the case with outbreaks, cases have been seen beyond the borders of Alabama or the United States where it started, with cases of hepatitis with an unknown cause among children being reported across the globe with roughly 650 cases spread across 33 different countries. Doctors and researchers are working to determine the cause of the outbreak in order to curb the case count, but until then check out our podcast and the resources below to help you stay informed on the latest happenings in Infection Prevention and Control.
Listen to a podcast from Dr. Wes Stubblefield, District Medical Officer for the Northern and Northeastern Public Health Districts at the Alabama Department of Public Health on this recent outbreak of pediatric hepatitis.
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