Antimicrobial Resistance and Multi-Drug Resistant Organism in Hospitals and Long-Term Care Facilities

Antimicrobial resistance happens when germs like bacteria and fungi develop the ability to defeat the drugs designed to kill them. That means the germs are not killed and continue to grow. Resistant infections can be difficult, and sometimes impossible to treat. Multidrug-resistant organisms are bacteria’s that have become resistant to certain antibiotics, and these antibiotics can no longer be used to control or kill the bacteria. Antibiotics are important medicines. They help fight infections that are caused by bacteria. Bacteria that resist treatment with more than one antibiotic are called multidrug-resistant organisms (MDROs for short), (,2023).

Examples of (MDROs), includes methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE) and certain gram-negative bacilli (GNB) which have important infection control implications that either have not been addressed or received only limited consideration (CDC,2015).

Below are recommended resources for hospitals and long-term care facilities on MDROs:

The Changing Landscape of Antimicrobial Resistance Following the COVID-19 Pandemic
General Recommendations for Routine Prevention and Control of MDROs in Healthcare Settings
Preventing the Spread of Novel or Targeted Multidrug-resistant Organisms (MDROs)
Infection Prevention of MDROs in Long-Term Care Settings

Candida auris: A multi-drug resistant pathogen

Candida auris is an emerging pathogen that results in nosocomial infections and is considered a serious global health problem. It was first observed as a novel  Candida species in 2009 and has been isolated in 35 countries.

C. auris may cause invasive infections associated with high mortality. It is considered a multi-drug resistant species, having variable resistance patterns to many typical antifungal agents used to treat other Candida infections.

The CDC is concerned about C. auris for three main reasons:

  1. It is often multidrug-resistant, meaning that it is resistant to multiple antifungal drugs commonly used to treat Candida infections. Some strains are resistant to all three available classes of antifungals.
  2. It is difficult to identify with standard laboratory methods, and it can be misidentified in labs without specific technology. Misidentification may lead to inappropriate management.
  3. It has caused outbreaks in healthcare settings. For this reason, it is important to quickly identify C. auris in a hospitalized patient so that healthcare facilities can take special precautions to stop its spread.

Candida Auris: What is it? Can we stop it? | ARC IPC

Resources for Candida auris:

General Information:
Infection Prevention:
For Healthcare Providers: