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Doxorubicin (DOX, an anthracycline) is a widely used chemotherapy agent against various forms of cancer. However, it is known to induce dose-dependent cardiotoxicity that leads to adverse cardiac complications. Our lab investigates the role of microRNA-377 in anticancer drug-induced cardiotoxicity in mice. Read the full article at: https://www.frontiersin.org/articles/10.3389/fcvm.2021.737826/full

The work is supported through grants from National Institutes of Health (NIH) and American Heart Association.

Details of the research article:

microRNA-377 Signaling Modulates Anticancer Drug-Induced Cardiotoxicity in Mice
John Henderson, Praveen K. Dubey, Mallikarjun Patil, Sarojini Singh, Shubham Dubey, Rajasekaran Namakkal Soorappan, Ramaswamy Kannappan, Palaniappan Sethu, Gangjian Qin, Jianyi Zhang, Krishnamurthy P.
Front. Cardiovasc. Med., 16 August 2021 | https://doi.org/10.3389/fcvm.2021.737826

Research Intern, Mr. Terry successfully completes 8-weeks UAB-Center for Community OutReach Development (CORD) Summer Science Program (Blazing to Biomedical Careers Program). At the end of the program, interns showcase their work through poster presentation. Terry’s research work is focused on Midkine, a heparin-binding growth and its role in fibroblast biology. We wish the best to Terry.

Drs. Sarojini Singh and Mallikarjun Patil co-mentored Terry. Thanks to their fantastic team effort!

Learn more about UAB-CORD program at: https://www.uab.edu/cord/

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Ms. Divya, research volunteer in the lab wins Emergent Scholarship 2021. Divya is an undergrad from UAB SciTech HONORS program. She has worked on several research projects in the lab, including depression effects on heart disease, diabetes effect on cardiomyocyte etc and has co-authored a peer-reviewed manuscript (Front. Cell Dev. Biol., 03 December 2019| https://doi.org/10.3389/fcell.2019.00315).

Divya’s previous work as volunteer has resulted in multiple awards: click here to read the post

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John Henderson, PhD Student in the lab, successfully defended his dissertation. The study investigates miRNA regulation of anticancer drug-induced cardiac pathology. Congratulations to John for achieving this important milestone.

Research Intern, Mr. David successfully completes 8-weeks UAB-Center for Community OutReach Development (CORD) Summer Science Program. David’s research work is titled “Effect of hyperglycemia on macrophage-derived exosomes and its impact on cardiac fibroblast”. Congratulations!

Dr. Mallikarjun Patil co-mentored David. Thanks to his effort!

Learn more about UAB-CORD program at: https://www.uab.edu/cord/

Dr. Darukeshwara Joladarashi receives postdoctoral research fellowship award from American Heart Association. The fellowship will support his research work from July 2016- Jun 2018. His project is focused on studying the role of serine threonine kinase 35 in diabetic heart disease.

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Ms. Divya, high school summer research volunteer in the lab receives multiple awards for her research work on “Effect of hyperglycemia on cardiomyocyte cell death”

Charter school of Wilmington Junior research Science Fair

3rd place (in Biomedical category) at Junior research science fair, .

Delaware Technical Community College Science Expo

2^nd place (Medicine and Health category)

Delaware Valley Science Fair in Philadelphia

Won three special awards under Biomedical category:

Janssen R&D Excellence in Cardiovascular and Metabolism Research Award (2nd place)

Leonardo DaVinci Society Award

Society for In Vitro Biology Award

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Postdoctoral Fellow, Dr. Prince Jeyabal receives American Heart Association (AHA) BCVS New Investigator travel award, New Orleans, LA

Postdoctoral fellow, Dr. Rajarajan A Thandavarayan receives AHA postdoctoral fellowship award

Dr. Rajarajan A Thandavarayan receives postdoctoral research fellowship award from American Heart Association. The fellowship will support his research work from July 2015- Jun 2017. His project is focused on studying the role of sirtuins in macrophage biology and function in the heart.