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Melkani Lab

Heersink School of Medicine

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Publications


  • Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption.  Nat Commun. 10, 2700. 2019
  • Time-Restricted Eating to Prevent and Manage Chronic Metabolic Diseases.  Annual Review of Nutrition.  39:291-315. 2019
  • Suppression of myopathic lamin mutations by muscle-specific activation of AMPK and modulation of downstream signaling.  Human Molecular Genetics.  28:351-371. 2019
  • Increasing autophagy and blocking Nrf2 suppress laminopathy-induced age-dependent cardiac dysfunction and shortened lifespan.  Aging Cell.  17:e12747-e12747. 2018
  • Prolonged cross-bridge binding triggers muscle dysfunction in a Drosophila model of myosin-based hypertrophic cardiomyopathy.  eLife.  7. 2018
  • TRiC/CCT chaperonins are essential for maintaining myofibril organization, cardiac physiological rhythm, and lifespan.  FEBS Letters.  591:3447-3458. 2017
  • Time-restricted feeding for prevention and treatment of cardiometabolic disorders. J Physiol, 595: 3691-3700. 2017
  • A Drosophila model of dominant inclusion body myopathy 3 shows diminished myosin kinetics that reduce muscle power and yield myofibrillar defects. Dis Model Mech, 10(6): 761–771. 2017
  • A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila.  Journal of Molecular Biology.  428:2446-2461. 2016
  • Using Drosophila as an integrated model to study mild repetitive traumatic brain injury.  Scientific Reports.  6. 2016
  • Huntington’s Disease-Induced Cardiac Disorders Affect Multiple Cellular Pathways. Reactive Oxygen Species, 2(5), 325–338. 2016
  • The Relay/Converter Interface Influences Hydrolysis of ATP by Skeletal Muscle Myosin II.  Journal of Biological Chemistry.  291:1763-1773. 2016
  • A Failure to Communicate.  Journal of Biological Chemistry.  290:29270-29280. 2015
  • Time-restricted feeding attenuates age-related cardiac decline in Drosophila.  Science.  347:1265-1269. 2015
  • Mapping Interactions between Myosin Relay and Converter Domains That Power Muscle Function.  Journal of Biological Chemistry.  289:12779-12790. 2014
  • Drosophila as a potential model to ameliorate mutant Huntington-mediated cardiac amyloidosis.  Rare Diseases.  2:e968003-e968003. 2014
  • The UNC-45 Myosin Chaperone.  International Review of Cell and Molecular Biology.  103-144. 2014
  • Huntington’s Disease Induced Cardiac Amyloidosis Is Reversed by Modulating Protein Folding and Oxidative Stress Pathways in the Drosophila Heart.  PLoS Genetics.  9:e1004024-e1004024. 2013
  • Expression of the inclusion body myopathy 3 mutation in Drosophila depresses myosin function and stability and recapitulates muscle inclusions and weakness. Molecular Biology of the Cell. 23:11, 2057-2065. 2012
  • Interaction of oxidized chaperonin GroEL with an unfolded protein at low temperatures. Biosci Rep 1. 32 (3): 299–303. 2012
  • Alternative Relay and Converter Domains Tune Native Muscle Myosin Isoform Function in Drosophila.  Journal of Molecular Biology.  416:543-557. 2012
  • Transgenic expression and purification of myosin isoforms using the Drosophila melanogaster indirect flight muscle system.  Methods.  56:25-32. 2012
  • Two Drosophila Myosin Transducer Mutants with Distinct Cardiomyopathies Have Divergent ADP and Actin Affinities.  Journal of Biological Chemistry.  286:28435-28443. 2011
  • Drosophila UNC-45 accumulates in embryonic blastoderm and in muscles, and is essential for muscle myosin stability.  Journal of Cell Science.  124:699-705. 2011
  • The UNC-45 Chaperone Is Critical for Establishing Myosin-Based Myofibrillar Organization and Cardiac Contractility in the Drosophila Heart Model.  PLoS ONE.  6:e22579-e22579. 2011
  • Drosophila UNC-45 prevents heat-induced aggregation of skeletal muscle myosin and facilitates refolding of citrate synthase.  Biochemical and Biophysical Research Communications.  396:317-322. 2010
  • Mutating the Converter–Relay Interface of Drosophila Myosin Perturbs ATPase Activity, Actin Motility, Myofibril Stability and Flight Ability.  Journal of Molecular Biology.  398:625-632. 2010
  • Alternative Exon 9-Encoded Relay Domains Affect More than One Communication Pathway in the Drosophila Myosin Head.  Journal of Molecular Biology.  389:707-721. 2009
  • Divalent cations stabilize GroEL under conditions of oxidative stress.  Biochemical and Biophysical Research Communications.  368:625-630. 2008
  • Protection of GroEL by its methionine residues against oxidation by hydrogen peroxide.  Biochemical and Biophysical Research Communications.  347:534-539. 2006
  • αB-Crystallin Maintains Skeletal Muscle Myosin Enzymatic Activity and Prevents its Aggregation under Heat-shock Stress.  Journal of Molecular Biology.  358:635-645. 2006
  • On the chaperonin activity of GroEL at heat-shock temperature. Int. J. Biochem. Cell Biol., 37(7), 1375–1385. 2005
  • Hydrogen peroxide induces the dissociation of GroEL into monomers that can facilitate the reactivation of oxidatively inactivated rhodanese. Int. J. Biochem. Cell Biol., 36(3), 505–518. 2003
  • Oxidized GroEL can function as a chaperonin.  Frontiers in Bioscience.  9:724-724. 2004
  • GroEL interacts transiently with oxidatively inactivated rhodanese facilitating its reactivation.  Biochemical and Biophysical Research Communications.  294:893-899. 2002
  • Synthesis, conformation and vibrational dynamics of the peptide -Ser-Cys-Lys-Leu-Asp-Phe-, a fragment of apolipoprotein B. Indian J Biochem Biophys. 39(6):410-8. 2002
  • Recurrent strokes–an interesting pedigree.  Journal of the Association of Physicians of India.  49:765-766. 2001
  • Lipoprotein(a) and coronary heart disease in Indian population.  Journal of the Association of Physicians of India.  47:1157-1160. 1999
  • Oxidative stress and metabolic control in non-insulin dependent diabetes mellitus. Indian J Biochem Biophys. 34(6):512-7. 1997

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