Tag: cpam

UAB’s Center for Precision Animal Modeling Receives Continuing NIH Support

The UAB Center for Precision Animal Modeling (CPAM) has received renewed NIH funding (Grant No. 2U54OD030167-06) through 2030 to expand its efforts in modeling human genetic disease. This continuation supports the next phase of the Center’s work (CPAM2.0), enhancing its established framework for variant interpretation, disease modeling, and therapeutic discovery.

The Bioinformatics Section, led by Dr. Liz Worthey, will enhance CPAM’s computational framework through new applications of machine learning, generative AI, and cross-species analysis. This includes expanding Rosalution, which streamlines data integration, variant curation, and collaboration across CPAM teams. The renewed funding underscores CPAM’s role in translating genomic findings into actionable insights that accelerate diagnosis and treatment for rare diseases.

CGDS and Rosalution Featured in NIH Research Highlights

We’re excited to share that our lab’s work was featured in the NIH Research Highlights post on the University of Alabama at Birmingham’s (UAB) Center for Precision Animal Modeling (C-PAM). This recognition underscores our contributions to advancing precision disease modeling, a field at the forefront of personalized medicine.

C-PAM is one of three U54 centers established under the NIH Precision Disease Modeling Initiative, focused on creating advanced animal models for precision therapies targeting complex disorders like ciliopathies and Roberts syndrome. Our tool, Rosalution, plays a key role in these efforts, helping link unique human genomic variants to disease with high-throughput, cost-effective pipelines.

This recognition highlights our lab’s commitment to developing innovative tools that enhance our understanding of disease mechanisms and empower clinicians and researchers.

Read more about the initiative and C-PAM’s work here.