We are a multi-disciplinary computational team of computational biologists, bioinformaticians, computer scientists, and software engineers. Each member of the lab is trained to use these approaches to address research questions relating to disease biology and precision medicine. We work in collaboration with clinicians, researchers, and foundations in the US and around the world, to translate data in to knowledge to drive discovery, development, and delivery of omics based precision medicine. As part of the UAB School of Medicine and Departments of Pediatrics and Pathology, we aspire to help patients, families, and those who take care of them through development and application of groundbreaking tools and strategies for diagnosis and prognosis. We train individuals with a biology background who would like to develop computational skills. We also train individuals with a computer science background who would like to develop biological understanding so that they can study disease and improving patient outcomes. If you are interested in becoming part of the team please reach out.
What do we do? What is our science? How do we do it?
Our center develops and applies a variety of computational biology and data science based methods, tools, and algorithms to generate knowledge that can advance human health and disease research.
- We develop:
- Tools and methods for molecular diagnosis and prognosis
- Strategies for discovery of genotype-phenotype associations including identification of clinically relevant modifiers
- Commercial-grade tertiary analysis software and other tools to enable scientific discovery and data interpretation
- To aid in:
- Uncovering the cause of disease
- Understanding differences in disease presentation
- Identification of potential treatment and processes
- By applying:
- Computational biology approaches such as systems biology, multi-omics, comparative genomics, structural biology, biomodeling, ontologies
- Machine learning methods including data exploration, feature selection, modeling, explainable AI, interpretability, visualisation
- Software development expertise for design, architecture, algorithm development, usability
A bit about us. Who are we? How do we work?
- We love doing science and engineering and we feel lucky to be part of this team doing this work together
- We strive for excellence in all we do and look to be our own toughest critics
- We are one team with many specialties, working collaboratively in pursuit of science, and we are open and transparent in our goals
- We are willing to step up to new opportunities and tough challenges
- We seek productive and constructive criticism from colleagues
- We are accountable for our errors; the buck stops with us; individually and as a team
- We strive to be generous with our time and resources
- We are willing to work hard to solve hard problems
- We are a little intense at times and for sure a bit quirky and we like it that way; it’s one of our strengths
- We value the diversity of our team, which we think should mirror the diversity of the people our team serves
- We care a lot about maintaining an inclusive culture
- We do not take ourselves too seriously
- We embrace the concept of ‘a rising tide lifts all boats’; accomplishments of any team member contribute to the overall good reputation of our team and helps us all