Select Publications


Williams AP, Garner EF, Waters AM, Stafman LL, Aye JM, Markert HR, Stewart JE, Beierle EA. Investigation of PP2A and Its Endogenous Inhibitors in Neuroblastoma Cell Survival and Tumor Growth. Transl Oncol. 2018 Oct; 12(1):84-95. doi: 10..1016/j.tranon.2018.09.011. PubMed PMID: 30286326; PubMed Central PMCID: PMC616910 

Waters AM, Stewart JE, Atigadda VR, Mroczek-Musulman E, Muccio DD, Grubbs CJ, Beierle EA. Preclinical Evaluation of a Novel RXR Agonist for the Treatment of Neuroblastoma. Mol Cancer Ther. 2015 Jul;14(7):1559-69. doi: 10.1158/1535-7163.MCT-14-1103. Epub 2015 May 5. PubMed PMID: 25944918; PubMed Central PMCID: PMC4496261.

Gillory LA, Stewart JE, Megison ML, Waters AM, Beierle EA. Focal adhesion kinase and p53 synergistically decrease neuroblastoma cell survival. J Surg Res.  2015 Jun 15;196(2):339-49. doi: 10.1016/j.jss.2015.03.021. Epub 2015 Mar 14. PubMed PMID: 25862488; PubMed Central PMCID: PMC4442704.

Beierle EA, Ma X, Stewart JE, Megison M, Cance WG, Kurenova EV. Inhibition of the focal adhesion kinase and vascular endothelial growth factor receptor-3 interaction leads to decreased survival in human neuroblastoma cell lines. Mol Carcinog. 2014 Mar;53(3):230-42. doi: 10.1002/mc.21969. Epub 2012 Oct 12. PubMed PMID: 23065847; PubMed Central PMCID: PMC3809027.

Gillory LA, Megison ML, Stewart JE, Mroczek-Musulman E, Nabers HC, Waters AM, Kelly V, Coleman JM, Markert JM, Gillespie GY, Friedman GK, Beierle EA. Preclinical evaluation of engineered oncolytic herpes simplex virus for the treatment of neuroblastoma. PLoS One. 2013 Oct 10;8(10):e77753. doi: 10.1371/journal.pone.0077753. eCollection 2013. PubMed PMID: 24130898; PubMed Central PMCID: PMC3795073.

Megison ML, Stewart JE, Nabers HC, Gillory LA, Beierle EA. FAK inhibition decreases cell invasion, migration and metastasis in MYCN amplified neuroblastoma. Clin Exp Metastasis. 2013 Jun;30(5):555-68. doi: 10.1007/s10585-012-9560-7. Epub 2012 Dec 4. PubMed PMID: 23208732; PubMed Central PMCID: PMC3625446.

Beierle EA, Ma X, Stewart J, Nyberg C, Trujillo A, Cance WG, Golubovskaya VM. Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma. Cell Cycle. 2010 Mar 1;9(5):1005-15. Epub 2010 Mar 14. PubMed PMID: 20160475; PubMed Central PMCID: PMC2855768.

Beierle EA, Ma X, Trujillo A, Kurenova EV, Cance WG, Golubovskaya VM. Inhibition of focal adhesion kinase and src increases detachment and apoptosis in human neuroblastoma cell lines. Mol Carcinog. 2010 Mar;49(3):224-34. doi: 10.1002/mc.20592. PubMed PMID: 19885861; PubMed Central PMCID: PMC2849163.

Renal Tumors 

Waters AM, Stewart JE, Atigadda VR, Mroczek-Musulman E, Muccio DD, Grubbs CJ, Beierle EA. Preclinical Evaluation of UAB30 in Pediatric Renal and Hepatic Malignancies. Mol Cancer Ther. 2016 May;15(5):911-21. doi: 10.1158/1535-7163.MCT-15-0521. Epub 2016 Feb 12. PubMed PMID: 26873726; PubMed Central PMCID: PMC4873350.

Megison ML, Gillory LA, Stewart JE, Nabers HC, Mrozcek-Musulman E, Beierle EA. FAK inhibition abrogates the malignant phenotype in aggressive pediatric renal tumors. Mol Cancer Res. 2014 Apr;12(4):514-26. doi: 10.1158/1541-7786.MCR-13-0505. Epub 2014 Jan 24. PubMed PMID: 24464916; PubMed Central PMCID: PMC3989502.


Waters AM, Stafman LL, Garner EF, Mruthyunjayappa S, Stewart JE, Friedman GK, Coleman JM, Markert JM, Gillespie GY, Beierle EA. Effect of Repeat Dosing of Engineered Oncolytic Herpes Simplex Virus on Preclinical Models of Rhabdomyosarcoma. Transl Oncol. 2016 Oct;9(5):419-430. doi: 10.1016/j.tranon.2016.07.008. PubMed PMID: 27751346; PubMed Central PMCID: PMC5067929.

Waters AM, Stafman LL, Garner EF, Mruthyunjayappa S, Stewart JE, Mroczek-Musulman E, Beierle EA. Targeting Focal Adhesion Kinase Suppresses the Malignant Phenotype in Rhabdomyosarcoma Cells. Transl Oncol. 2016 Aug;9(4):263-73. doi: 10.1016/j.tranon.2016.06.001. Epub 2016 Jun 24. PubMed MID: 27567948; PubMed Central PMCID: PMC4925808.


Stafman LL, Williams AP, Garner EF, Aye JM, Stewart JE, Yoon KJ, Whelan K, Beierle EA. Targeting PIM Kinases Affects Maintenance of CD133 Tumor Cell Population in Hepatoblastoma. Transl Oncol. 2018 Nov; 12(2):200-208. doi: 10.1016/j.tranon.2018.10.008. PubMed MID: 30412911; PubMed Central PMCID: PMC6222086.

Stafman LL, Mruthyunjayappa S, Waters AM, et al. Targeting PIM kinase as a therapeutic strategy in human hepatoblastoma. Oncotarget. 2018;9(32):22665-22679. Published 2018 Apr 27. doi:10.18632/oncotarget.25205. PubMed MID: 29854306; PubMed Central PMCID: PMC5978256

Gillory LA, Stewart JE, Megison ML, Nabers HC, Mroczek-Musulman E, Beierle EA. FAK Inhibition Decreases Hepatoblastoma Survival Both In Vitro and In Vivo. Transl Oncol. 2013 Apr;6(2):206-15. Epub 2013 Apr 1. PubMed PMID: 23544173; PubMed Central PMCID: PMC3610546.


Garner EF, Stafman LL, Williams AP, Aye JM, Goolsby C, Atigadda VR, Moore BP, Nan L, Stewart JE, Hjelmeland AB, Friedman GK, Beierle EA. UAB30, a novel RXR agonist, decreases tumorigenesis and leptomeningeal disease in group 3 medulloblastoma patient-derived xenografts. J Neurooncol. 2018 Nov; 140(2): 209-224. doi: 10.1007/s11060-018-2950-1. Epub 2018 Aug 21. PubMed PMID: 30132166; PubMed Central PMCID: PMC6239946

Garner EF, Williams AP, Stafman LL, Aye JM, Mroczek-Musulman E, Moore BP, Stewart JE, Friedman GK, Beierle EA. FTY720 Decreases Tumorigenesis in Group 3 Medulloblastoma Patient-Derived Xenografts. Scientific Reports. 2018 May. PubMed PMID: 29720672; PubMed Central PMCID: PMC5932040

Friedman GK, Moore BP, Nan L, Kelly VM, Etminan T, Langford CP, Xu H, Han X, Markert JM, Beierle EA, Gillespie GY. Pediatric medulloblastoma xenografts including molecular subgroup 3 and CD133+ and CD15+ cells are sensitive to killing by oncolytic herpes simplex viruses. Neuro Oncol. 2016 Feb;18(2):227-35. doi: 10.1093/neuonc/nov123. Epub 2015 Jul 16. PubMed PMID: 26188016; PubMed Central PMCID: PMC4724175.