Publications

Our groups past 10 years publications can be accessed here:

2020

  • Yim, Y.Y., Betke, K.M., McDonald, W.H. et al. Author Correction: The in vivo specificity of synaptic Gβ and Gγ subunits to the α2a adrenergic receptor at CNS synapses. Sci Rep 10, 2966 (2020). https://doi.org/10.1038/s41598-020-59022-2 Download
  • Shun Yan, Rassarin Thienthanasit, Dongquan Chen, Erik Engelen, Joanna Brühl, David K. Crossman, Robert Kesterson, Qin Wang, Karim Bouazoune, Kai Jiao: CHD7 regulates cardiovascular development through ATP-dependent and -independent activities. Proceedings of the National Academy of Sciences Nov 2020, 117 (46) 28847-28858. DOI: 10.1073/pnas.2005222117 Download
  • Yong Zhang, Lili Song, Huansheng Dong, Do-sung Kim, Zhen Sun, Heather Boger, Qin Wang, and Hongjun Wang. Spinophilin-deficient mice are protected from diet-induced obesity and insulin resistance. American Journal of Physiology-Endocrinology and Metabolism. 2020 319:2, E354-E362 Download
  • Zhang F, Gannon M, Chen Y, et al. Beta-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3beta/tau cascade. Sci Transl Med. 2020; 12(526). https://doi.org/10.1126/scitranslmed.aay6931. Download

2019

  • Yim, Y.Y., Betke, K.M., McDonald, W.H. et al. The in vivo specificity of synaptic Gβ and Gγ subunits to the α2a adrenergic receptor at CNS synapses. Sci Rep 9, 1718 (2019). https://doi.org/10.1038/s41598-018-37222-1 Download
  • M. Gannon, Q. Wang. Complex noradrenergic dysfunction in alzheimer’s disease: low norepinephrine input is not always to blame. Brain Res., 1702 (2019), pp. 12-16, 10.1016/j.brainres.2018.01.001 Download

2017

  • Yunjia Chen, Christopher Booth, Hongxia Wang, Raymond X. Wang, Dimitra Terzi, Venetia Zachariou, Kai Jiao, Jin Zhang and Qin Wang. Molecular Pharmacology December 1, 2017, 92 (6) 630-639; DOI: https://doi.org/10.1124/mol.117.109462 Download
  • Zhang, F., Gannon, M., Chen, Y., Zhou, L., Jiao, K. and Wang, Q. (2017), The amyloid precursor protein modulates α2A-adrenergic receptor endocytosis and signaling through disrupting arrestin 3 recruitment. The FASEB Journal, 31: 4434-4446. https://doi.org/10.1096/fj.201700346R Download
  • M. Scarduzio, C.N. Zimmerman, K.L. Jaunarajs, Q. Wang, D.G. Standaert, L.L. McMahon. Strength of cholinergic tone dictates the polarity of dopamine D2 receptor modulation of striatal cholinergic interneuron excitability in DYT1 dystonia. Exp. Neurol., 295 (2017), pp. 162-175 Download
  • Wu H, Cottingham C, Chen L, Wang H, Che P, Liu K, et al. (2017) Age-dependent differential regulation of anxiety- and depression-related behaviors by neurabin and spinophilin. PLoS ONE 12(7): e0180638. https://doi.org/10.1371/journal.pone.0180638 Download
  • B.A.S. Reyes, A.F. Carvalho, P. Szot, D.J. Kalamarides, Q. Wang, L.G. Kirby, E.J. Van Bockstaele. Cortical adrenoceptor expression, function and adaptation under conditions of cannabinoid receptor deletion. Exp. Neurol., 292 (2017), pp. 179-192. Download
  • Cottingham, C.; Che, P.; Zhang, W.; Wang, H.; Wang, R. X.; Percival, S.; Birky, T.; Zhou, L.; Jiao, K.; Wang, Q. Diverse arrestin-recruiting and endocytic profiles of tricyclic antipsychotics acting as direct α(2A) adrenergic receptor ligands. Neuropharmacology 2017, 116, 38– 49. Download

2016

  • Yin Peng, Lanying Song, Ding Li, Robert Kesterson, Jianbo Wang, Lizhong Wang, Gregg Rokosh, Bingruo Wu, Qin Wang, Kai Jiao, Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice , Cardiovascular Research, Volume 112, Issue 2, November 2016, Pages 532–542, https://doi.org/10.1093/cvr/cvw200 Download

2015

  • Che P, Chen Y, Lu R, Peng N, Gannon M, Wyss JM, et al. (2015) Spinophilin Is Indispensable for the α2B Adrenergic Receptor-Elicited Hypertensive Response. PLoS ONE 10(8): e0135030. https://doi.org/10.1371/journal.pone.0135030 Download
  • C. Cottingham, C.J. Ferryman, Q. Wang. Alpha2 adrenergic receptor trafficking as a therapeutic target in antidepressant drug action. Prog. Mol. Biol. Transl. Sci., 132 (2015), pp. 207-225. https://doi.org/10.1016/bs.pmbts.2015.03.007 Download
  • Gannon M, Che P, Chen Y, Jiao K, Roberson ED and Wang Q (2015) Noradrenergic dysfunction in Alzheimer’s disease. Front. Neurosci. 9:220. doi: 10.3389/fnins.2015.00220 Download
  • Alicia M. Hall, Benjamin T. Throesch, Susan C. Buckingham, Sean J. Markwardt, Yin Peng, Qin Wang, Dax A. Hoffman, Erik D. Roberson. Tau-Dependent Kv4.2 Depletion and Dendritic Hyperexcitability in a Mouse Model of Alzheimer’s Disease. Journal of Neuroscience. 15 April 2015, 35 (15) 6221-6230; DOI: 10.1523/JNEUROSCI.2552-14.2015 Download

2014

  • Cathel, A.M., Reyes, B.A.S., Wang, Q., Palma, J., Mackie, K., Van Bockstaele, E.J. and Kirby, L.G. (2014), Cannabinoid modulation of alpha2 adrenergic receptor function in rodent medial prefrontal cortex. Eur J Neurosci, 40: 3202-3214. https://doi.org/10.1111/ejn.12690 Download
  • Yin Peng, Lanying Song, Mei Zhao, Cristina Harmelink, Paige Debenedittis, Xiangqin Cui, Qin Wang, Kai Jiao, Critical roles of miRNA-mediated regulation of TGFβ signalling during mouse cardiogenesis, Cardiovascular Research, Volume 103, Issue 2, 15 July 2014, Pages 258–267, https://doi.org/10.1093/cvr/cvu126 Download
  • Yuelong Liu, Cristina Harmelink, Yin Peng, Yunjia Chen, Qin Wang, Kai Jiao, CHD7 interacts with BMP R-SMADs to epigenetically regulate cardiogenesis in mice, Human Molecular Genetics, Volume 23, Issue 8, 15 April 2014, Pages 2145–2156, https://doi.org/10.1093/hmg/ddt610 Download
  • Stephanie A. Flavin, Robert T. Matthews, Qin Wang, E. Chris Muly, Danny G. Winder. α2A-Adrenergic Receptors Filter Parabrachial Inputs to the Bed Nucleus of the Stria Terminalis. Journal of Neuroscience. 9 July 2014, 34 (28) 9319-9331; DOI: 10.1523/JNEUROSCI.0822-14.2014 Download
  • De Fusco, M., Vago, R., Striano, P., Di Bonaventura, C., Zara, F., Mei, D., Kim, M.S., Muallem, S., Chen, Y., Wang, Q., Guerrini, R. and Casari, G. (2014), The α2B-adrenergic receptor is mutant in cortical myoclonus and epilepsy. Ann Neurol., 75: 77-87. https://doi.org/10.1002/ana.24028 Download

2013

  • C. Cottingham, R. Lu, K. Jiao, Q. Wang. Cross-talk from β-adrenergic receptors modulates α2A-adrenergic receptor endocytosis in sympathetic neurons via protein kinase A and spinophilin. J. Biol. Chem., 288 (2013), pp. 29193-29205 Download

2012

  • Wang Q. α2-adrenergic receptors. Prim on the Auton Nerv Syst. 2012. doi:10.1016/B978-0-12-386525-0.00010-X. Download
  • C. Cottingham, A. Jones, Q. Wang. Desipramine selectively potentiates norepinephrine-elicited ERK1/2 activation through the alpha2A adrenergic receptor. Biochem. Biophys. Res. Commun., 420 (2012), pp. 161-165 Download
  • Yunjia Chen, Yin Liu, Christopher Cottingham, Lori McMahon, Kai Jiao, Paul Greengard, Qin Wang. Neurabin Scaffolding of Adenosine Receptor and RGS4 Regulates Anti-Seizure Effect of Endogenous Adenosine. Journal of Neuroscience. 22 February 2012, 32 (8) 2683-2695; DOI: 10.1523/JNEUROSCI.4125-11.2011 Download
  • C. Cottingham, X. Li, Q. Wang. Noradrenergic antidepressant responses to desipramine in vivo are reciprocally regulated by arrestin3 and spinophilin. Neuropharmacology, 62 (7) (2012), pp. 2354-2362 Download
  • C. Cottingham, Q. Wang. alpha2 adrenergic receptor dysregulation in depressive disorders: implications for the neurobiology of depression and antidepressant therapy. Neurosci. Biobehav. Rev., 36 (10) (2012 Nov), pp. 2214-2225 Download

2011

  • Qin Wang. Adrenergic Receptors – Preface. Current Topics in Membranes. Volume 67, 2011. https://doi.org/10.1016/B978-0-12-384921-2.00011-2 Download
  • C. Cottingham, Y. Chen, K. Jiao, Q. Wang. The antidepressant desipramine is an arrestin-biased ligand at the α 2A-adrenergic receptor driving receptor down-regulation in vitro and in vivo. J. Biol. Chem., 286 (41) (2011), pp. 36063-36075 Download
  • C. Cottingham, H. Chen, Y. Chen, Y. Peng, Q. Wang. Genetic variations of a2-adrenergic receptors illuminate the diversity of receptor functions. Q. Wang (Ed.), Advances in Adrenergic Receptor Biology, Academic Press, San Diego (2011), pp. 162-190 Download
  • P. Debenedittis, C. Harmelink, Y. Chen, Q. Wang, K. Jiao. Characterization of the novel interaction between muskelin and TBX20, a critical cardiogenic transcription factor. Biochem. Biophys. Res. Commun., 409 (2011), pp. 338-343 Download
  • Nie X., Brown C.B., Wang Q., Jiao K. Inactivation of Bmp4 from the Tbx1 Expression Domain Causes Abnormal Pharyngeal Arch Artery and Cardiac Outflow Tract Remodeling. Cells Tissues Organs 2011;193:393–403. Download
  • X. Nie, Q. Wang, K. Jiao. Dicer activity in neural crest cells is essential for craniofacial organogenesis and pharyngeal arch artery morphogenesis. Mech. Dev., 128 (2011), pp. 200-207, 10.1016/j.mod.2010.12.002 Download
  • Brady A.E., Chen Y., Limbird L.E., Wang Q. (2011) Study of GPCR–Protein Interactions Using Gel Overlay Assays and Glutathione-S-Transferase-Fusion Protein Pull-Downs. In: Willars G., Challiss R. (eds) Receptor Signal Transduction Protocols. Methods in Molecular Biology (Methods and Protocols), vol 746. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-126-0_19 Download
  • Song, L., Zhao, M., Wu, B., Zhou, B., Wang, Q. and Jiao, K. (2011), Cell autonomous requirement of endocardial Smad4 during atrioventricular cushion development in mouse embryos. Dev. Dyn., 240: 211-220. https://doi.org/10.1002/dvdy.22493 Download