Welcome to the Kiedrowski Lab at UAB
The Kiedrowski Laboratory is part of the Division of Pulmonary, Allergy and Critical Care in the Department of Medicine in the UAB Heersink School of Medicine. Our research is focused on investigating epithelial biology and polymicrobial interactions in chronic respiratory diseases, particularly in cystic fibrosis (CF) and chronic rhinosinusitis (CRS). We use airway epithelial cell co-culture models and other in vitro model systems to ask how the host airway environment influences microbial behavior in multi-species communities and how host-microbe interactions can affect bacterial pathogenicity, persistence and antimicrobial tolerance. For more information on our ongoing projects, visit our Research page!
Recent Publications
Staphylococcus aureus phenol-soluble modulins have dispersal and anti-aggregation activity towards corynebacteria. Journal of Bacteriology. 2025.
Effects of Elevated Glucose on Bacterial Respiratory Infections in Cystic Fibrosis and Chronic Airway Diseases. International Journal of Molecular Sciences. 2025.
Targeting the MEK1/2 pathway to combat Staphylococcus aureus infection and inflammation in cystic fibrosis. mBio. 2025.
Evaluating the effects of ivacaftor exposure on Staphylococcus aureus small colony variant development and antibiotic tolerance. JAC Antimicrobial Resistance. 2024.
Temperature influences commensal-pathogen dynamics in a nasal epithelial cell co-culture model. mSphere. 2024.
Acute Infection with a Tobramycin-Induced Small Colony Variant of Staphylococcus aureus Causes Increased Inflammation in the Cystic Fibrosis Rat Lung. Infection and Immunity. 2022.
See a complete list under Publications.
