Gonorrhea is no longer just a common sexually transmitted infection (STI) – it has become one of the world’s most dangerous drug-resistant infections. Gonorrhea is a preventable and curable STI that infected over 82 million adults in 2020. The consequences of infection include infertility and the increased risk of HIV. The impact of gonorrhea is dangerous enough to raise international caution, but the development of drug-resistant gonorrhea has resulted in this not just being a sexual health issue, but a public health emergency. The issue of antimicrobial resistance is coupled by delayed diagnosis, stigma, and gaps in global health, leaving millions of lives vulnerable and jeopardizing their human right to health.
What is Gonorrhea?
Gonorrhea is caused by Neisseria gonorrhoeae which is a bacteria that is transmitted sexually. The infection primarily impacts younger populations from 15 to 49 years old and largely women. Generally, in international populations, LGBTQ+, racial minorities, indigenous populations, and sex workers bear a disproportionate burden of gonorrhea.
This burden is both physical and emotional. When working through the development of the infection, it may bring up concerns for distrust; a patient in Georgia bravely accounts for her story with gonorrhea with a date. From unprotected intercourse to getting tested early, she shares the dangers in onset and the importance of urgency with the infection.
If the infection is not treated in a timely manner, there could be significant reproductive health complications such as pelvic inflammatory disease, which is an infection of the female reproductive organs, and chorioamnionitis, a serious pregnancy complication, both of which contribute to the onset risk of infertility. This is coupled by the heightened risk of HIV acquisition.
The danger of gonorrhea is that asymptomatic infections, making up around 90% of infections in women and 56% to 87% of infections in men, can silently spread in communities. This increases the risk of transmission and complications due to the infection. This amplifies the public health crisis of sexually transmitted infections throughout the world, placing an increased burden on communities with already limited resources.

Credit: Wikimedia Commons – DFID/ Will Crowne
CC 2.0 Also available at: https://www.flickr.com/photos/dfid/48758842257/
What is Antimicrobial Resistance?
Antimicrobial resistance is a critical global health development, claiming the title of the “Silent Pandemic.” Its danger is developed through the misuse of antimicrobials in humans, animals, and plants; this results in the development of bacteria and pathogens that are resistant to drugs. Although new drugs are developed to support intervention against a variety of infections across the world, there is always the risk of antimicrobial resistance, regardless of how complex the drug is. The issue of antimicrobial resistance spans beyond low and middle income countries; rather, it affects countries from all income levels. However, its drivers are exacerbated by poverty and inequality.
In 2021, antimicrobial resistance caused around 1.1 million deaths, with a forecast of 1.9 million deaths by 2050. This is coupled by financial losses, resulting in an economic impact of trillions of dollars across the world. Along with these losses, there is the problem of drug-resistant HIV, tuberculosis, and malaria. The onset of drug-resistant forms of these diseases results in a lack of access to critical medication that can promise maintenance or help address the disease at hand. This challenge has been approached by a variety of factors. From the expected means, like education and public awareness, to the integration of artificial intelligence, there are a variety of tools to help combat and address antimicrobial resistance.
Antimicrobial Resistance of Gonorrhea
What is unique about the relationship between antimicrobial resistance and gonorrhea is that gonorrhea has grown resistant to nearly every drug that is used to treat it. This has resulted in there being only one class of antibiotics available for gonorrhea control. When reflecting on its accessibility, it is easily covered by insurance throughout the United States and other Global North countries, but treatment is not as accessible in the Global South, requiring collaborations and private-public partnerships.
Global conversations suggest that resistance to ceftriaxone and cefixime, common antibiotics used for treatment of gonorrhea, have risen to 5% and 11% respectively, whereas resistance to ciprofloxacin, another formerly effective drug against gonorrhea, has reached 95%. Data for the United States, specifically through the Gonococcal Isolate Surveillance Project, has suggested that gonorrhea has decreased susceptibility to an antibiotic, and laboratory results demonstrate that increased antibiotics are critical to halt all growth. Internationally, resistance to key treatments further supports the need for surveillance of gonorrhea, but this may not be feasible.
Factors Contributing to the Rise of Antimicrobial Resistance
Antimicrobial resistance has been on the rise across the globe for a variety of reasons. The largest reason, as mentioned, is antibiotic misuse. This is driven by the administration of antibiotic prescriptions without a policy or treatment regimen, which is especially common in developing countries, as many prescription medicines are available over the counter in these countries. In developed countries, lack of health literacy or forewarning by healthcare providers also fuels misuse. The nature of antibiotic prescriptions also contributes to the global burden of antimicrobial resistance; its being overprescribed by healthcare providers contributes to the development of resistance long term, especially when these medicines are prescribed over lengthy courses.
Another factor that contributes to antimicrobial resistance is the general delay of care for sexually transmitted diseases and infections. Generally, barriers to care-seeking can be attitudes, social stigma or mental conditions, which can be exacerbated by health system factors like lack of access to a clinic or lack of insurance. This delays timely treatment and access to a treatment regimen that would work best for the patient.
The Need for Gonorrhea Resistance Surveillance
In spite of certain medical interventions’ not working, there is one action that can promise a healthier future and that is expanding surveillance. Genomic surveillance, the process of monitoring and analyzing the genetic makeup of a pathogen, can help guide gonorrhea control. There have been a variety of programs that have supported understanding gonorrhea. From the CDC’s Gonococcal Isolate Surveillance Project to the WHO’s Gonococcal Antimicrobial Surveillance Program, data about gonococcal antimicrobial susceptibility has been collected. With this data, information is mobilized to key regions, which then informs the gonorrhea strategy in each country. Surveillance is challenged by access to funding and laboratory resources, but this approach still demonstrates that collecting key data can help support global treatment guidelines and policies.
What Is Next?
As the global fight against antimicrobial resistance occurs, it is critical for us all to do our part. Within the conversation of prevention, it is critical that safe sex practices, like condom use and STI testing, are leveraged. If symptoms appear, it is critical to seek our care and not start any medication regime without medical guidance. Within all conversations, it is critical to normalize conversations about sexual health and seeking out medical help when needed. As the danger of drug-resistant gonorrhea is growing, it is critical for everyone to take a part in the journey, helping us prevent a future where gonorrhea is untreatable. Drug-resistant gonorrhea is not inevitable; it’s a preventable crisis. The choices we make today will determine whether future generations inherit an infection we can still control and are able to fully enjoy their human right to health.










