Category: REU

Deadline for REU Applications Ended April 1, 2016

We are pleased with the tremendous response to our call for applications to our Research Experience for Undergraduates program for summer 2016 here at UAB.  Given the hundreds of applications that we received, the competition was quite impressive.  The names of our 2016 REU participants will be posted as soon as all offers have been made and accepted.

We thank every applicant for their interest in our program and we hope that all eligible applicants will apply again next year.  In the meantime, for those well deserving applicants that applied and were not selected, we are hopeful that many of them were selected to other programs.

Updated:  April 7, 2016 – Meet our 2016 REU Participants

2014 REU Danna Nozik Takes 1st Place at AIChE Conference

Congratulations to 2014 REU Danna Nozik.  Danna won first place at the 2014  AIChE (American Institute of Chemical Engineers) poster competition in the category of Materials Engineering and Sciences.  We are exremely proud of Danna for such fine job.  Below is Danna’s abstract.

ABSTRACT:  There is a huge demand for small-diameter vascular grafts, as the majority of vascular disease cases involve small-caliber blood vessels. Recently, electrospinning has gained attention as a valuable technique for the fabrication of scaffolds for blood vessel engineering, as electrospinning produces nanofibers that closely approximate the structure of native extracellular matrix (ECM).

Accordingly, electrospun scaffolds were fabricated in a 3D tubular structure from a blend of the synthetic polymers, viscoelastic and durable polycaprolactone (PCL) and relatively fast-degrading shape memory poliglecaprone (PGC). The scaffolds were coated with a physiological biomatrix, HuBiogelTM. The biohybrid graft was found to exhibit mechanical properties comparable to those of native blood vessels, and the HuBiogelTM coating imparted bioactivity. The coating was crosslinked using EDC and the natural crosslinker genipin (Gp) to improve its stability in physiological conditions. This study evaluated the effects of EDC- and Gp-crosslinking on the scaffold mechanical, structural, and morphological properties. Additionally, coating stability was studied to assure the presence of collagenous biomatrix on the scaffold for effective cell-matrix interactions.

Mechanical testing showed little difference between EDC- and Gp-crosslinked scaffolds; both retained mechanical properties in the range of native human arteries (tensile strength 1-2 MPa, tensile modulus 9-12 MPa). SEM imaging revealed that while crosslinking with EDC resulted in an increase in fiber diameter compared to uncrosslinked scaffolds, Gp-crosslinking did not affect fiber diameter; the majority of fibers in EDC and Gp-crosslinked scaffolds had diameters ranging from approximately 0.9 – 1.4 microns and 0.7 – 1.2 microns, respectively. This is in the upper range of fiber diameters in native extracellular matrix. Coating stability studies using picrosirius red (PSR) stain showed that EDC-crosslinked scaffolds were more effective than Gp-crosslinked scaffolds in enhancing the stability of the biomatrix coating.