Arora Translational Lab
Our lab was started in the fall of 2016. Under the directorship of Dr. Pankaj Arora, MD, FAHA, and Dr. Garima Arora, MD, MRCP, the lab has grown leaps and bounds since its start. The primary focus of the lab is the natriuretic peptide system and the causal role of deficiency of the natriuretic peptide signalling in the development of cardiometabolic diseases. The lab is focused on translating genetic, molecular, and animal discoveries around the natriuretic peptide system into an improved and comprehensive understanding of human physiology through clinically focused patient-oriented research. The lab is also actively involved in research focused on cardiovascular epidemiology, human clinical trials, molecular biology, and cardiovascular genetics.
Explaination of NP deficiency: A cause of cardio metabolic disease experimental data animal model NP receptor knockout mice, effect of genotype and dietary sodium on baseline plasma NT-proANP levels, effect of genotype on plasma NT-proANP levels during saline challeng, translating genetic association to biological function, translating rs5068 association to function, validation of the predicted binding of miR-425 with the NPPA 3’UTR, modified miR-425 inhibits NPPA 3’UTR with minor allele, induced pluripotent stem cell derived human cardiomyocytes (AA genotype), effect of dietary sodium and genotype on plasma miR-415 levels, fro association to causation, from population genetic studies to clinical medicine, obesity (a natriuretic peptide deficiency state) and cardio metabolic disease.