We use both conventional confocal microscopy and super resolution microscopy including STORM and STED to examine the synaptic, subsynaptic and even single molecule scale structural changes.

(left) Confocal and STED image of the same mouse retina cross section immunostained with specific antibodies targeting photoreceptor synaptic molecule mGluR6 (green), Pikachurin (red) and ribbon CTBP2 (blue). (right) zoom in pictures of the region in white square in left.