Wille CK and Zhang X, Haws S, Denu J, Sridharan R. Antagonistic H3K79me-H3K9ac crosstalk determines elongation at housekeeping genes to promote pluripotency. bioRxiv 2022.09.26.509534 [in Review]
Wille CK, Neumann EN, Deshpande AJ, Sridharan R. DOT1L interaction partner AF10 controls patterning of H3K79 methylation to maintain cell identity. bioRxiv 2020.12.17.423347 [in Review]
Wille CK, Sridharan R. Connecting the DOTs on Cell Identity. Front Cell Dev Biol. 2022;10:906713. doi: 10.3389/fcell.2022.906713. eCollection 2022 Review. PMID: 35733849
Wille CK, Sridharan R. DOT1L inhibition enhances pluripotency beyond acquisition of epithelial identity and without immediate suppression of the somatic transcriptome. Stem Cell Reports. 2022 Feb 8;17(2):384-396. doi: 10.1016/j.stemcr.2021.12.004. Epub 2022 Jan 6. PMID: 34995500
Haws SA, Yu D, Ye C, Wille CK, Nguyen LC, Krautkramer KA, Tomasiewicz JL, Yang SE, Miller BR, Liu WH, Igarashi K, Sridharan R, Tu BP, Cryns VL, Lamming DW, Denu JM. Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence. Mol Cell. 2020 Apr 16;78(2):210-223.e8. doi: 10.1016/j.molcel.2020.03.004. Epub 2020 Mar 23. PMID: 32208170
Hoebe E, Wille C, Hagemeier S, Kenney S, Greijer A, and Middeldorp J. Epstein-Barr virus gene BARF1 expression is regulated by the epithelial differentiation factor ΔNp63α in undifferentiated nasopharyngeal carcinoma. Cancers (Basel). 2018 Mar 17;10(3):76. doi: 10.3390/cancers10030076. PMID: 29562599
Wille CK, Li Y, Rui L, Johannsen EC, Kenney SC. Restricted TET2 Expression in Germinal Center Type B Cells Promotes Stringent Epstein-Barr Virus Latency. J Virol. 2017 Mar 1;91(5). doi: 10.1128/JVI.01987-16. Print 2017 Mar 1. PMID: 28003489
Wille CK, Nawandar DM, Henning AN, Ma S, Oetting KM, Lee D, Lambert P, Johannsen EC, Kenney SC. 5-hydroxymethylation of the EBV genome regulates the latent to lytic switch. Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):E7257-65. doi: 10.1073/pnas.1513432112. Epub. 2015 Dec 9. PMID: 26663912
Nawandar DM, Wang A, MakielskiK, Lee D, Ma S, Barlow E, Reusch J, Jiang R, Wille CK, Greenspan D, Greenspan JS, Mertz JE, Hutt-Fletcher L, Johannsen EC, Lambert PF, and Kenney SC. Differentiation-dependent KLF4 expression promotes lytic Epstein-Barr virus infection in epithelial cells. PLoS Pathog. 2015 Oct 2;11(10):e1005195. doi: 10.1371/journal.ppat.1005195. eCollection 2015 Oct. PMID: 26431332
Wille CK, Nawandar DM, Panfil AR, Ko MM, Hagemeier SR, and Kenney SC. Viral genome methylation differentially affects the ability of BZLF1 versus BRLF1 to activate Epstein-Barr virus lytic gene expression and viral replication. J Virol. 2013 Jan;87(2):935-50. doi: 10.1128/JVI.01790-12. Epub 2012 Nov 7. PMID: 23135711
Hoebe EK, Wille C, Hopmans ES, Robinson AR, Middeldorp JM, Kenney SC, and Greijer AE. Epstein-Barr virus transcription activator R upregulates BARF1 expression by direct binding to its promoter, independent of methylation. J Virol. 2012 Oct;86(20):11322-32. doi: 10.1128/JVI.01161-12. Epub 2012 Aug 15. PMID: 22896599
Robinson AR, Kwek SS, Hagemeier SR, Wille CK, and Kenney SC. 2011. Cellular transcription factor Oct-1 interacts with the Epstein-Barr virus BRLF1 protein to promote disruption of viral latency. J Virol. 2011 Sep;85(17):8940-53. doi: 10.1128/JVI.00569-11. Epub 2011 Jun 22. PMID: 21697476
