Publications

Hindy G¹, Tyrrell DJ¹, Vasbinder A¹, Wei C, Presswalla F, Wang H, Blakely PK, Ozel AB, Graham SE, Holton GH, Dowsett J, Fahed AC, Amadi KM, Erne GK, Tekumulla A, Ismail A, Launius C, Sotoodehnia N, Pankow JS, Thørner LW, Erikstrup C, Pedersen OB, Banasik K, Brunak S, Ullum H, Eugen-Olsen J, Ostrowski SR, Haas ME, Nielsen JB, Lotta LA, Engström G, Melander O, Orho-Melander M, Zhao L, Murthy VL, Pinsky DJ, Willer CJ, Heckbert SR, Reiser J, Goldstein DR, Desch KC, Hayek SS. Clinical, genetic, and experimental increase in soluble urokinase plasminogen activator receptor levels promotes atherosclerosis. J Clin Invest. 2022 Oct 4. PMID: 36194491. ¹Co-first author

Amartey J, Okagbue C, Saccoh A, Buffonge S, Francois A, Tcheandjieu C, Mitchell S, Tyrrell DJ, Kamin Mukaz D. Black In Cardio: promoting diversity and representation in the cardiovascular field. Nat Rev Cardiol. 2022 Sep 20. PMID: 36127463.

Tyrrell DJ*, Chen JC, Li BY, Wood SC, Rosebury-Smith W, Remmer HA, Jiang L, Zhang M, Salmon M, Ailawadi G, Yang B, Goldstein DR. Aging Alters the Aortic Proteome in Health and Thoracic Aortic Aneurysm. ATVB. 2022 May. PMID: 35510553. *Corresponding author
^{Featured article in ATVB August 2022 edition with accompanying editorial: Watson AMD, Chen YC, Karlheinz P. Vascular Aging and Vascular Disease Have Much in Common! ATVB. (Jun 2022). PMID: 35735019.}

Tyrrell DJ*, Blin MJ, Song J, Wood SC, Goldstein DR. Aging Impairs Mitochondrial Function and Mitophagy and Elevates Interleukin 6 Within the Cerebral Vasculature. J Am Heart Assoc. 2020 Dec; 9(23):e017820. PMID: 33225820. *Corresponding author

Tyrrell DJ, Goldstein DR. Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6. Nat Rev Cardiol. 2021 Jan;18(1):58-68. Review. PMID: 32918047.
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Tyrrell DJ, Blin MG, Song J, Wood SC, Zhang M, Beard DA, Goldstein DR. Age-Associated Mitochondrial Dysfunction Accelerates Atherogenesis. Circ Res. 2020 Jan 31. PMID: 31818196.
^{>4500 downloads and in 97th percentile on Altmetric}

Smith CA, Tyrrell DJ, Kulkarni UA, Wood S, Leng L, Zemans RL, Bucala R, Goldstein DR. Macrophage migration inhibitory factor enhances influenza-associated mortality in mice. JCI Insight. 2019 Jul 11. PMID: 31292300.

Tyrrell DJ, Bharadwaj MS, Jorgensen MJ, Register TC, Shively C, Andrews RN, Neth B, Keene CD, Mintz A, Craft S, Molina AJA. Blood-Based Bioenergetic Profiling Reflects Differences in Brain Bioenergetics and Metabolism. Oxid Med Cell Longev. 2017 Oct 2. PMID: 29098063.

Bellumkonda L, Tyrrell D, Hummel SL, Goldstein DR. Pathophysiology of heart failure and frailty: a common inflammatory origin?. Aging Cell. 2017 Mar 7. PMID: 28266167.

Tyrrell DJ, Bharadwaj MS, Jorgensen MJ, Register TC, Molina AJ. Blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: Implications for a minimally invasive biomarker of mitochondrial health. Redox Biol. 2016 Sep 21. PMID: 27693859.

Tyrrell DJ, Bharadwaj MS, Van Horn CG, Kritchevsky SB, Nicklas BJ, Molina AJ. Respirometric Profiling of Muscle Mitochondria and Blood Cells Are Associated With Differences in Gait Speed Among Community-Dwelling Older Adults. J Gerontol A Biol Sci Med Sci. 2014 Jul 16. PMID: 25030980.

Bharadwaj MS, Tyrrell DJ, Leng I, Demons JL, Lyles MF, Carr JJ, Nicklas BJ, Molina AJ. Relationships between mitochondrial content and bioenergetics with obesity, body composition and fat distribution in healthy older adults. BMC Obes. 2015. PMID: 26448868.

Tyrrell DJ, Bharadwaj MS, Van Horn CG, Marsh AP, Nicklas BJ, Molina AJ. Blood-cell bioenergetics are associated with physical function and inflammation in overweight/obese older adults. Exp Gerontol. 2015 Jul 29. PMID: 26226578.

Bharadwaj MS, Tyrrell DJ, Lyles MF, Demons JL, Rogers GW, Molina AJ. Preparation and respirometric assessment of mitochondria isolated from skeletal muscle tissue obtained by percutaneous needle biopsy. J Vis Exp. 2015 Feb 7. PMID: 25741892.