Publications

Publications

Easter M, Hirsch MJ, Harris E, Howze Iv PH, Matthews EL, Jones LI, Bollenbecker S, Vang S, Tyrrell DJ, Sanders YY, Birket SE, Barnes JW, Krick S. Fibroblast growth factor receptors mediate cellular senescence in the cystic fibrosis airway epithelium. JCI Insight. 2024 Jun 25;. doi: 10.1172/jci.insight.174888. [Epub ahead of print] PubMed PMID: 38916962.

Vardaman D 3rd, Ali MA, Bolding C, Tidwell H, Stephens H, Tyrrell DJ. Development of a Spectral Flow Cytometry Analysis Pipeline for High-Dimensional Immune Cell Characterization. bioRxiv. 2024 Jun 22;. doi: 10.1101/2024.06.19.599633. PubMed PMID: 38948780; PubMed Central PMCID: PMC11213029.

Corbin-Stein NJ, Childers GM, Webster JM, Zane A, Yang YT, Ali MA, Sandoval IM, Manfredsson FP, Kordower JH, Tyrrell DJ, Harms AS. Tissue resident memory CD8+ T cells are present but not critical for demyelination and neurodegeneration in a mouse model of multiple system atrophy. bioRxiv. 2024 Jun 3;. doi: 10.1101/2024.06.02.597035. PubMed PMID: 38895456; PubMed Central PMCID: PMC11185520.

Song J, Zhang Y, Frieler RA, Andren A, Wood SC, Tyrrell DJ, Sajjakulnukit P, Deng JC, Lyssiotis CA, Mortensen RM, Salmon M, Goldstein DR. Itaconate suppresses atherosclerosis by activating a Nrf2-dependent anti-inflammatory response in macrophages in mice. J Clin Invest. 2023 Dec 12;. doi: 10.1172/JCI173034. [Epub ahead of print] PubMed PMID: 38085578.

Ali MA, Gioscia-Ryan R, Yang D, Sutton NR, Tyrrell DJ. Cardiovascular Aging: Spotlight on Mitochondria. Am J Physiol Heart Circ Physiol. 2023 Dec 1;. doi: 10.1152/ajpheart.00632.2023. [Epub ahead of print] Review. PubMed PMID: 38038719.

Tyrrell DJ, Wragg KM, Chen J, Wang H, Song J, Blin MG, Bolding C, Vardaman D 3rd, Giles K, Tidwell H, Ali MA, Janappareddi A, Wood SC, Goldstein DR. Clonally expanded memory CD8(+) T cells accumulate in atherosclerotic plaques and are pro-atherogenic in aged mice. Nat Aging. 2023 Nov 23;. doi: 10.1038/s43587-023-00515-w. [Epub ahead of print] PubMed PMID: 37996758.
^{Research Highlight in Nature Reviews Cardiology: Huynh K. Clonal expansion of CD8+ T cells in aged mice linked to pro-atherogenic phenotype. Nat Rev Cardiol. 2023 Dec 8. doi: 10.1038/s41569-023-00981-0. PMID: 38066087.}

Zhang X, Tyrrell DJ, Alliston T, Schilling B, Yousefzadeh MJ, Schafer MJ. Senescence and Inflammation: Summary of a Gerontological Society of America and National Institute on Aging-Sponsored Symposium. J Gerontol A Biol Sci Med Sci. 2023 May 6;. doi: 10.1093/gerona/glad120. PMID: 37148367

Woitowich NC, Hengel SR, Solis C, Vilgalys TP, Babdor J, Tyrrell DJ. Analysis of NIH K99/R00 Awards and the Career Progression of Awardees. bioRxiv. 2023 Dec 7;. doi: 10.1101/2023.01.26.525751. PubMed PMID: 37162873; PubMed Central PMCID: PMC10168267.
^{99th percentile on Altmetric}

Song J, Farris D, Ariza P, Moorjani S, Varghese M, Blin M, Chen J, Tyrrell D, Zhang M, Singer K, Salmon M, Goldstein DR. Age-associated adipose tissue inflammation promotes monocyte chemotaxis and enhances atherosclerosis. Aging Cell. 2023 Feb;22(2):e13783. doi: 10.1111/acel.13783. Epub 2023 Jan 23. PMID: 36683460

Hindy G¹, Tyrrell DJ¹, Vasbinder A¹, Wei C, Presswalla F, Wang H, Blakely PK, Ozel AB, Graham SE, Holton GH, Dowsett J, Fahed AC, Amadi KM, Erne GK, Tekumulla A, Ismail A, Launius C, Sotoodehnia N, Pankow JS, Thørner LW, Erikstrup C, Pedersen OB, Banasik K, Brunak S, Ullum H, Eugen-Olsen J, Ostrowski SR, Haas ME, Nielsen JB, Lotta LA, Engström G, Melander O, Orho-Melander M, Zhao L, Murthy VL, Pinsky DJ, Willer CJ, Heckbert SR, Reiser J, Goldstein DR, Desch KC, Hayek SS. Clinical, genetic, and experimental increase in soluble urokinase plasminogen activator receptor levels promotes atherosclerosis. J Clin Invest. 2022 Oct 4. PMID: 36194491. ¹Co-first author
^{99th percentile on Altmetric}

Amartey J, Okagbue C, Saccoh A, Buffonge S, Francois A, Tcheandjieu C, Mitchell S, Tyrrell DJ, Kamin Mukaz D. Black In Cardio: promoting diversity and representation in the cardiovascular field. Nat Rev Cardiol. 2022 Sep 20. PMID: 36127463.

Tyrrell DJ*, Chen JC, Li BY, Wood SC, Rosebury-Smith W, Remmer HA, Jiang L, Zhang M, Salmon M, Ailawadi G, Yang B, Goldstein DR. Aging Alters the Aortic Proteome in Health and Thoracic Aortic Aneurysm. ATVB. 2022 May. PMID: 35510553. *Corresponding author
^{Featured article in ATVB August 2022 edition with accompanying editorial: Watson AMD, Chen YC, Karlheinz P. Vascular Aging and Vascular Disease Have Much in Common! ATVB. (Jun 2022). PMID: 35735019.}

Tyrrell DJ*, Blin MJ, Song J, Wood SC, Goldstein DR. Aging Impairs Mitochondrial Function and Mitophagy and Elevates Interleukin 6 Within the Cerebral Vasculature. J Am Heart Assoc. 2020 Dec; 9(23):e017820. PMID: 33225820. *Corresponding author

Tyrrell DJ, Goldstein DR. Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6. Nat Rev Cardiol. 2021 Jan;18(1):58-68. Review. PMID: 32918047.
^{>8000 downloads and in 98th percentile on Altmetric}

Tyrrell DJ, Blin MG, Song J, Wood SC, Zhang M, Beard DA, Goldstein DR. Age-Associated Mitochondrial Dysfunction Accelerates Atherogenesis. Circ Res. 2020 Jan 31. PMID: 31818196.
^{>4500 downloads and in 97th percentile on Altmetric}

Smith CA, Tyrrell DJ, Kulkarni UA, Wood S, Leng L, Zemans RL, Bucala R, Goldstein DR. Macrophage migration inhibitory factor enhances influenza-associated mortality in mice. JCI Insight. 2019 Jul 11. PMID: 31292300.

Tyrrell DJ, Bharadwaj MS, Jorgensen MJ, Register TC, Shively C, Andrews RN, Neth B, Keene CD, Mintz A, Craft S, Molina AJA. Blood-Based Bioenergetic Profiling Reflects Differences in Brain Bioenergetics and Metabolism. Oxid Med Cell Longev. 2017 Oct 2. PMID: 29098063.

Bellumkonda L, Tyrrell D, Hummel SL, Goldstein DR. Pathophysiology of heart failure and frailty: a common inflammatory origin?. Aging Cell. 2017 Mar 7. PMID: 28266167.

Tyrrell DJ, Bharadwaj MS, Jorgensen MJ, Register TC, Molina AJ. Blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: Implications for a minimally invasive biomarker of mitochondrial health. Redox Biol. 2016 Sep 21. PMID: 27693859.

Tyrrell DJ, Bharadwaj MS, Van Horn CG, Kritchevsky SB, Nicklas BJ, Molina AJ. Respirometric Profiling of Muscle Mitochondria and Blood Cells Are Associated With Differences in Gait Speed Among Community-Dwelling Older Adults. J Gerontol A Biol Sci Med Sci. 2014 Jul 16. PMID: 25030980.

Bharadwaj MS, Tyrrell DJ, Leng I, Demons JL, Lyles MF, Carr JJ, Nicklas BJ, Molina AJ. Relationships between mitochondrial content and bioenergetics with obesity, body composition and fat distribution in healthy older adults. BMC Obes. 2015. PMID: 26448868.

Tyrrell DJ, Bharadwaj MS, Van Horn CG, Marsh AP, Nicklas BJ, Molina AJ. Blood-cell bioenergetics are associated with physical function and inflammation in overweight/obese older adults. Exp Gerontol. 2015 Jul 29. PMID: 26226578.

Bharadwaj MS, Tyrrell DJ, Lyles MF, Demons JL, Rogers GW, Molina AJ. Preparation and respirometric assessment of mitochondria isolated from skeletal muscle tissue obtained by percutaneous needle biopsy. J Vis Exp. 2015 Feb 7. PMID: 25741892.