2nd Short Course on Statistical Genetics and Genomics
| Held On: | Monday 7/9/12 – Friday 7/13/12 |
| Location: | The University of Alabama at Birmingham 1401 University Blvd. 1st Floor Heritage Hall – Lecture Room 104 Birmingham, AL 35233 |
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Lodging Options: |
DoubleTree Hotel Birmingham |
Overview
Bursary Services
Faculty & Board
Contact
Major efforts are under way to uncover the specific genetic components of many complex human disorders and quantitative traits. These efforts are generating an unprecedented wealth of data that requires sophisticated statistical analysis in order to maximize the information gleaned from each study. Likewise, many advances have been made in statistical methods for the study of complex genetic traits, and new statistical methods continue to be promulgated. To expedite and significantly advance the search for specific genes that predispose to these complex traits, we propose a series of annual hands-on short courses on statistical genetics and statistical genomics which will enable a far greater number of researchers, including clinical researchers, to participate in, contribute to, and lead such research. These short courses will help equip students, post-doctoral fellows, junior investigators and senior investigators new to the field with the statistical genetic approaches necessary to expedite genomic discovery. The courses will be taught by leading experts in statistical genetics/genomics. Each 5-day course will provide substantial “hands-on” computer training that will effectively increase the number and the expertise of investigators who are pursuing genetic and genomic research. We expect approximately 50 students to attend each course, allowing for intensive interaction between students and faculty. Lectures will be supplemented with extensive discussion sessions, handouts, presentation of worked examples, and interactive demonstrations of statistical genetic data analyses. Finally, we will also initiate a new bursary service, providing funding for 10 course participants to travel to visit a course faculty member of their choice to help initiate or finish a particular project. This will provide an unprecedented collaborative opportunity for course participants and faculty.
Schedule of Events:
**NOTE: You will need Microsoft Silverlight to view videos.
Mon 7/9/12
| Time | Speaker | Topic | Video |
| 08:00 – 08:30 | Derry Crawford | Registration | |
| 08:30 – 08:45 | Hemant Tiwari PhD | Introductory Remarks | |
| 08:45 – 09:45 | Gregory Pence PhD | Ethical Issues in Medical Research in Human Genetics |  |
| 09:45 – 10:00 | BREAK | ||
| 10:00 – 11:00 | Gregory Pence PhD | Part II – Ethical Issues in Research in Genetics | |
| 11:00 – 11:15 | BREAK | ||
| 11:15 – 12:15 | Nancy Cox PhD | Introduction to Genetics & Genomics | |
| 12:15 – 01:30 | LUNCH | ||
| 01:30 – 03:00 | Warren Ewens PhD | Introduction to Biostatistics | |
| 03:00 – 03:15 | BREAK | ||
| 03:15 – 04:15 | Jelai Wang | Introduction to ssglabvm, a virtual software lab | |
| 04:15 – 06:15 | Xiangqin Cui PhD | Introduction to R & Bio-conductor | |
Tue 7/10/12
| Time | Speaker | Topic | Video |
| 08:00 – 09:15 | Carl Langefeld PhD | Design, Analysis, and interpretation of GWAS | |
| 09:15 – 09:30 | BREAK | ||
| 09:30 – 10:45 | Suzanne Leal PhD | Rare Variants & Exome Sequencing | |
| 10:45 – 11:00 | BREAK | ||
| 11:00 – 12:15 | Mahlet Tadesse PhD | Structural Variation & Human Diseases (CNV Analysis) | |
| 12:15 – 01:30 | LUNCH | ||
| 01:30 – 02:00 | Faculty | Open Discussion | |
| 02:00 – 02:15 | BREAK | ||
| 02:15 – 06:00 | Wang, Tadesse and Zhi | PLINK, PENNCNV, Exome Sequence data analysis | |
Wed 7/11/12
| Time | Speaker | Topic | Video |
| 08:00 – 09:15 | Guilherme Rosa PhD | Microarrays and RNAseq: technologies and data processing | |
| 09:15 – 09:30 | BREAK | ||
| 09:30 – 10:45 | Guilherme Rosa PhD | Design and analysis of gene expression experiments | |
| 10:45 – 11:00 | BREAK | ||
| 11:00 – 12:15 | Shili Lin PhD | Epigenomics methods I | |
| 12:15 – 01:30 | LUNCH | ||
| 01:30 – 02:00 | Faculty | Open Discussion | |
| 02:00 – 02:15 | BREAK | ||
| 02:15 – 06:00 | Drs Cui and Lin | Affy, RMANOVA, Epigenomic Analysis, Chip Seq Software (DIME) | |
| 07:00 – 09:00 | Participants & Faculty | Social and Dinner | |
Thu 7/12/12
| Time | Speaker | Topic | Video |
| 08:00 – 09:15 | Shili Lin PhD | Epigenomics methods II | |
| 09:15 – 09:30 | BREAK | ||
| 09:30 – 10:45 | Alison Motsinger-Reif PhD | Pharmacogenetics/ Pharmacogenomics | |
| 10:45 – 11:00 | BREAK | ||
| 11:00 – 12:15 | Gustavo del los Campos PhD | Prediction of complex traits using whole genome regressions | |
| 12:15 – 01:30 | LUNCH | ||
| 01:30 – 02:45 | Faculty | Open Discussion | |
| 02:45 – 03:00 | BREAK | ||
| 03:00 – 06:00 | Amit Patki | GWAS Imputation | |
Fri 7/13/12
| Time | Speaker | Topic | Video |
| 08:00 – 09:15 | Laura Kelly Vaughan PhD | Pathway & Gene Network approaches for genome-wide association studies | |
| 09:15 – 09:30 | BREAK | ||
| 09:30 – 10:45 | Atul Butte MD, PhD | Discovering new drugs & diagnostics from 300 billion points of data | |
| 10:45 – 12:00 | All Faculty | Open Discussion | |
| 12:00 – 01:30 | LUNCH | ||
| 01:30 – 02:30 | Laura Kelly Vaughan PhD | Pathways/Gene Network Analysis software | |
| 02:30 | Adjourn | ||
Bursary Services. We will offer a novel service to participants to assist them either in their ongoing research projects or in a newly initiated project which could lead to publication in refereed journal or submission of an investigator initiated grant proposal. In addition to attending the regularly scheduled short course itself, one month after the short course participants will be encouraged to submit one page proposals on their projects indicating in each case the specific aim of the project and the name of the rotating faculty with whom they wish to work. Any faculty listed in the rotating faculty list is eligible to provide such service. Advisory board members will serve as reviewers and will assign scores between 1 and 5 to each proposal and convey them to Drs. Tiwari and Allison. We will then select the 10 participants with highest average scores. (In selecting the proposals for Bursary Awards, we also consider diversity in addition, but secondarily, to the scientific quality of the proposal.) We will serve as facilitators, contacting particular faculty to ask whether they are willing to help the participant in initiating and finishing the project. If they agree, we will encourage participants to contact the faculty to arrange to work on the project. When the project is nearly complete, the participant will visit the faculty for two days to get final assistance.
Within one month of the Bursary Service, both participant and faculty will be responsible to provide feedback on their experience and to provide information on the manuscript or grant proposal they submitted together. They may be asked to provide a copy of their manuscript and/or confirmation of the submitted grant proposal (the documents will not be distributed to any one and kept confidential). We will also keep track of publication status as well as approval of the grant proposal by conducting online searches of Pub Med. Medline, and NIH RePORTER to find out whether any of these trainees have publications or funded grants, especially in fields related to genetics. We strongly believe that this will bring high level of collaboration between faculty and participants.
UAB Faculty
- Hemant K. Tiwari, PhD – Section Head
- Xiangqin Cui, PhD – Associate Professor
Full List of Rotating Faculty can be found by Click here.
Advisory Board:
- Robert C Elston, PhD – Statistical Genetics/Genomics, Case Western Reserve University, Cleveland, Ohio
- Suzanne M Leal, PhD – Linkage/ Association, Department of Molecular and Human Genetics, Baylor University, Houston
- John K Hewitt, PhD – Behavioral Genetics, University of Colorado at Boulder, Boulder, Colorado
Contact Information:
Logistics: Derry Crawford
Department of Biostatistics
1665 University Blvd, RPHB 414
University of Alabama at Birmingham
Birmingham, AL 35294-0022
Phone: (205) 975-9193
Email: Statgenetics@uab.edu
Scientific: Hemant K Tiwari, PhD
Department of Biostatistics
1665 University Blvd, 420B
University of Alabama at Birmingham
Birmingham, AL 35294-0022
Phone: (205) 934-4907
Email: htiwari@uab.edu
Funding Sources:
National Institute of General Medical Sciences (NIGMS)
NIGMS Disclaimer:
This material is based upon work supported by the National Institute of General Medical Sciences (NIGMS) under Grant No. R25GM093044. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the NIGMS.
