2020-2021
Remodeling of the tumor microenvironment via disrupting Blimp1+ effector regulatory T-cells augments response to anti-PD-1 blockade.
Dixon ML,Luo L, Ghosh S, Grimes JM, LeavenworthJD, LeavenworthJW.
Mol Cancer (Impact factor: 27.4). 2021. doi: 10.1186/s12943-021-01450-3 Accepted
RNF2 ablation reprograms the tumor-immune microenvironment and stimulates durable NK and CD4+T-cell-dependent antitumor immunity.
Zhuo Z*,#, Luo L*, Xing C, Chen Y, Xu P, Li M, Zeng L, Li C, Ghosh S, Manna DD, Townes T, Britt WJ, Wajapeyee N, Sleckman BP, Chong Z, LeavenworthJW#, Yang ES#.
Nat Cancer. 2021; 2, 1018-1038. https://doi.org/10.1038/s43018-021-00263-z (*co-first author; #co-senior author).
>> News & Views, Nat Cancer. 2021. A PRC1-RNF2 knockout punch for cancer
Lineage Reprogramming of effector regulatory T cells in cancer.
Dixon ML, LeavenworthJD, LeavenworthJW.
Front Immunol. 2021 Jul 28;12:717421. doi: 10.3389/fimmu.2021.717421. PMID: 34394124
Immune activity and response differences of oncolytic viral therapy in recurrent glioblastoma: gene expression analyses of a Phase IB study.
Miller KE,Cassady KA, Roth JC, Clements J, Schieffer KM, Leraas K, Miller AR, Prasad N, LeavenworthJW, Aban IB, Whitley RJ, Gillespie GY, Mardis ER and Markert JM.
Clin cancer Res. 2021 Accepted
Dysregulated follicular regulatory T cells and antibody responses exacerbate EAE.
Luo L, Hu X, Dixon ML, Pope BJ, LeavenworthJD, Raman C, Meador WR, LeavenworthJW.
J Neuroinflammation. 2021 Jan 19;18(1):27. PMID: 33468194
2019
Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor.
Wang L, Shen E, Luo L, Rabe H, et al., Leavenworth JW.
Cell Reports, 2019 Nov 12;29(7):1848-1861.e6. PMID: 31722202
Deletion of the RNA regulator HuR in tumor-associated microglia and macrophages stimulates anti-tumor immunity and attenuates glioma growth.
Wang J, Leavenworth JW, Hjelmeland AB, et al., King PH.
Glia. 2019 Dec;67(12):2424-2439. PMID: 31400163
2018
Chromatin remodeling by the NuRD complex regulates development of follicular helper and regulatory T cells
Shen E, Wang Q, Rabe H, Liu W, Cantor H, Leavenworth JW.
PNAS. 2018 Jun 11. pii:201805239. doi: 10.1073/pnas.1805239115. PMID: 29891681
CD8+T cells expressing both PD-1 and TIGT but nto CD226 are dysfunctional in Acute Myeloid Leukemiaa (AML) patients.
Wang M, Bu J, Zhou M, Sido JM, Lin Y, Liu G, Lin Q, Xu X, Leavenworth JW*. Shen E*
Clin Immunol. 2018 May; 190:64-73. doi: 10.1016/j.clim.2017.08.021.Epub 2017 Sep 8. PMID: 28893624
*-co-senior author
Lymphocytes Contribute to the Pathophysiology of Neonatal Brain Injury.
Nazmi A, Albertsson AM, Rocha-Ferreira E, Zhang X, Vontell R, et al., Leavenworth JW, Wang X.
Front Neurol. 2018 Mar 29; 9;159. doi: 10.3389/fneur.2018.00159. eCollection 2018. PMIDL 29615958
γδ T Cells Contribute to Injury in the Developing Brain.
Albertsson Am, Zhang X, Vontell R, Bi D, Bronson RT, et al.,Leavenworth JW*, Wang X*
Am J pathol. 2018 Mar; 188(3):757-767. doi: 10.1016/j.ajpath.2017.11.012. Epub 2017 Dec 15. PMID: 29259560
*-co-senior author
Alphavirus Replicon DNA Vectors Expressing Ebola GP and VP40 Antigens Induce Humoral and Cellular Immune Reponses in Mice.
Ren S, Wei Q, Cai L, Yang X, Xing C, Tan F, Leavenworth JW
Front microbiol. 2018 Jan 10; 8:2662. doi:10.3389/fmicb.2017.02662.eCollection 2017. PMID: 29375526
2017
γδT cells but not αβT cells contribute to sepsis-induced white matter injury and motor abnormalities in mice.
Zhang X, Rocha-Ferrieria E, Li T, Vontell R, et al., Leavenworth, JW, Zhu C, Wang X
J Neuroinflammation. 2017 Dec 20; 14(1):255. doi: 10.1186/s12974-017-1029-9. PMID: 29262837
The Role of Microglia and Macrophages in CNS Homeostasis, Autoimmunity, and Cancer.
Yin J, Valin KL, Dixon ML, Leavenworth JW.
J Immunol Res. 2017; 2017:5150678. doi:10.1155/2017/5150678. Epub 2017 Dec 19. Review. PMID: 29410971
Newly Characterized Murine Undifferentiated Sarcoma Models Sensitive to Immunovirotherapy with Oncolytic HSV-1 M002.
Ring EK, Li R, Moore BP, Nan L, Kelly VM, Han X, Beierle EA, Markert JM, Leavenworth JW, Gillespie GY, Friedman GK.
Mol Ther Oncolytics. 2017 Sep 13; 7:27-36. doi.org/10.1016/j.omto.2017.09.003. eCollection 2017 Dec 15. PMID: 29034313
Modulation of the intratumoral immune landscape by oncolytic Herpes Simplex Virus virotherapy.
Yin J, Markert JM, Leavenworth JW.
Front. Oncol. 2017 Jun 26;7:136. doi: 10.3389/fonc.2017.00136. PMID: 28695111.
2015-2016
Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity.
Yin J*, Leavenworth JW*#,, Li Y, Luo Q, Xie H, Liu X, et al. (*co-first author; #co-senior author).
PNAS. 2015 Dec 29;112(52):15988-93. PMID: 26668377
NK cell-based cancer immunotherapy: from basic biology to clinical application.
Li Y, Yin J, Li T, Huang S, Yan H, Leavenworth J#, Wang X#. (#co-senior author).
Sci China Life Sci. 2015 Nov 20, doi: 10.1007/s11427-015-4970-9. PMID: 26588912.
A p85α–osteopontin axis couples the ICOS receptor to sustained Bcl-6 expression by follicular helper and regulatory T cells.
Leavenworth JW, Verbinnen B, Yin J, Huang H, Cantor H.
Nature Immunol. 2015 Jan;16(1): 96–106. [PMC4405167]
Intracellular osteopontin regulates homeostasis and function of natural killer cells.
Leavenworth JW, Verbinnen B, Wang Q, Shen E, Cantor H.
PNAS. 2015 Jan 13;112:494-9. [PMC4299239]
