2019

Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor.
Wang L, Shen E, Luo L, Rabe H, et al., Leavenworth JW.
Cell Reports, 2019 Nov 12;29(7):1848-1861.e6. PMID: 31722202

Deletion of the RNA regulator HuR in tumor-associated microglia and macrophages stimulates anti-tumor immunity and attenuates glioma growth.
Wang J, Leavenworth JW, Hjelmeland AB, et al., King PH Glia.
2019 Dec;67(12):2424-2439. PMID: 31400163

2018

Chromatin remodeling by the NuRD complex regulates development of follicular helper and regulatory T cells 
Shen E, Wang Q, Rabe H, Liu W, Cantor H, Leavenworth JW. 
PNAS. 2018 Jun 11. pii:201805239. doi: 10.1073/pnas.1805239115. PMID: 29891681


CD8+T cells expressing both PD-1 and TIGT but nto CD226 are dysfunctional in Acute Myeloid Leukemiaa (AML) patients. 
Wang M, Bu J, Zhou M, Sido JM, Lin Y, Liu G, Lin Q, Xu X, Leavenworth JW*. Shen E*
Clin Immunol. 2018 May; 190:64-73. doi: 10.1016/j.clim.2017.08.021.Epub 2017 Sep 8. PMID: 28893624
*-co-corresponding author


Lymphocytes Contribute to the Pathophysiology of Neonatal Brain Injury.
Nazmi A, Albertsson AM, Rocha-Ferreira E, Zhang X, Vontell R, et al., Leavenworth JW, Wang X.
Front Neurol. 2018 Mar 29; 9;159. doi: 10.3389/fneur.2018.00159. eCollection 2018. PMIDL 29615958


γδ T Cells Contribute to Injury in the Developing Brain.
Albertsson Am, Zhang X, Vontell R, Bi D, Bronson RT, et al.,Leavenworth JW*, Wang X*
Am J pathol. 2018 Mar; 188(3):757-767. doi: 10.1016/j.ajpath.2017.11.012. Epub 2017 Dec 15. PMID: 29259560
*-co-corresponding author


Alphavirus Replicon DNA Vectors Expressing Ebola GP and VP40 Antigens Induce Humoral and Cellular Immune Reponses in Mice.
Ren S, Wei Q, Cai L, Yang X, Xing C, Tan F, Leavenworth JW
Front microbiol. 2018 Jan 10; 8:2662. doi:10.3389/fmicb.2017.02662.eCollection 2017. PMID: 29375526

2017


γδT cells but not αβT cells contribute to sepsis-induced white matter injury and motor abnormalities in mice.
Zhang X, Rocha-Ferrieria E, Li T, Vontell R, et al., Leavenworth, JW, Zhu C, Wang X
J Neuroinflammation. 2017 Dec 20; 14(1):255. doi: 10.1186/s12974-017-1029-9. PMID: 29262837


The Role of Microglia and Macrophages in CNS Homeostasis, Autoimmunity, and Cancer. 
Yin J, Valin KL, Dixon ML, Leavenworth JW.
J Immunol Res. 2017; 2017:5150678. doi:10.1155/2017/5150678. Epub 2017 Dec 19. Review. PMID: 29410971


Newly Characterized Murine Undifferentiated Sarcoma Models Sensitive to Immunovirotherapy with Oncolytic HSV-1 M002. 
Ring EK, Li R, Moore BP, Nan L, Kelly VM, Han X, Beierle EA, Markert JM, Leavenworth JW, Gillespie GY, Friedman GK.
Mol Ther Oncolytics. 2017 Sep 13; 7:27-36. doi.org/10.1016/j.omto.2017.09.003. eCollection 2017 Dec 15. PMID: 29034313


Modulation of the intratumoral immune landscape by oncolytic Herpes Simplex Virus virotherapy. 
Yin J, Markert JM, Leavenworth JW.
Front. Oncol. 2017 Jun 26;7:136. doi: 10.3389/fonc.2017.00136. PMID: 28695111.

2015-2016

EZH2Slide1


Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity. 
Yin J*, Leavenworth JW*#,, Li Y, Luo Q, Xie H, Liu X, et al. (*co-first author; #co-corresponding author). 
PNAS. 2015 Dec 29;112(52):15988-93. PMID: 26668377

BCI6Slide2


NK cell-based cancer immunotherapy: from basic biology to clinical application.
Li Y, Yin J, Li T, Huang S, Yan H, Leavenworth J#, Wang X#. (#co-corresponding author).
Sci China Life Sci. 2015 Nov 20, doi: 10.1007/s11427-015-4970-9. PMID: 26588912.


A p85α–osteopontin axis couples the ICOS receptor to sustained Bcl-6 expression by follicular helper and regulatory T cells.
Leavenworth JW, Verbinnen B, Yin J, Huang H, Cantor H.
Nature Immunol. 2015 Jan;16(1): 96–106. [PMC4405167]

Intracellular osteopontin regulates homeostasis and function of natural killer cells.
Leavenworth JW, Verbinnen B, Wang Q, Shen E, Cantor H. 
PNAS. 2015 Jan 13;112:494-9. [PMC4299239]

2014


The effect of osteopontin and osteopontin-derived peptides on preterm brain injury.
Albertsson AM, Zhang X, Leavenworth J, Bi D, Nair S, Qiao L, Hagberg H, Mallard C, Cantor H, Wang X.
J Neuroinflammation. 2014 Dec 3;11(1):197. [PMC4266908]


The immune response after hypoxia-ischemia in a mouse model of preterm brain injury.
Albertsson AM, Bi D, Duan L, Zhang X, Leavenworth JW, Qiao L, Zhu C, Cardell S, Cantor H, Hagberg H, Mallard C, Wang X.
J Neuroinflammation. 2014 Sep 5;11(1):153. [PMC4172879]

2013


Amelioration of arthritis through mobilization of CD8+ regulatory T cells.
Leavenworth JW, Tang X, Kim HJ, Wang X, Cantor H.
J. Clin Invest. 2013; 123: 1382-9. PMCID: PMC3582146.

2010-2012


Mobilization of natural killer cells inhibits development of collagen-induced arthritis.
Leavenworth JW, Wang X, Wenander CS, Spee P, Cantor H.
PNAS. 2011;108:14584-9. PMCID: PMC3167502. (Research Highlight, Nat Rev Rheumatol. 2011; 7: 622. PMID: 22009332.)

NKcellsSlide3

Analysis of the cellular mechanism underlying inhibition of EAE after treatment with anti-NKG2A F(ab’)2.
Leavenworth JW, Schellack C, Kim HJ, Lu L, Spee P, Cantor H. 
PNAS. 2010;107:2562-7. PMCID: PMC2823885.

2007-2009


SUMO conjugation contributes to immune deviation in nonobese diabetic mice by suppressing c-Maf transactivation of IL-4.
Leavenworth JW, Ma X, Mo YY, Pauza ME.
J Immunol. 2009;183:1110-9. PMCID: PMC2965337.


Engagement of transgenic Ly49A inhibits mouse CD4 cell activation by disrupting T cell receptor, but not CD28, signaling.
Leavenworth JW, Pauza ME. 
Cell Immunol. 2009;257:88-96. PMID: 19362713.


c-Maf interacts with c-Myb to down-regulate Bcl-2 expression and increase apoptosis in peripheral CD4 cells.
Peng S, Lalani S, Leavenworth JW, Ho IC, Pauza ME
Eur J Immunol. 2007;37(10):2868-80. PMID: 17823980.