Ongoing Research Support

Alabama Enrichment Fund – Chen (PI)
10/1/15-9/30/25
Signaling Pathways in Endocrine Malignancies
This $2 million grant focuses investigating signaling pathways which regulate the proliferating of endocrine cancers and on developing novel strategies to translate laboratory findings to the clinics.

NIH/NIDDK T35 DK116670-01 – Chen/Locke (PI)
4/1/19-3/31/24
Short-Term Research Experiences Advancing Medical Students
The goal of this grant is to train medical students in translational and health services research.

NIH/NCI RO1CA228399 – Olson (PI)
12/1/18-11/30/23
Parathyroid Tumor Clonal Status as a Biomarker in Primary Hyperparathyroidism
This sub-contract from the University of Maryland is to study clonality in patients with hyperparathyroidism. Dr Chen serves as the UAB PI under subcontract.

NIH/NCI T32 CA220102 – Kennedy (PI)
7/1/18-6/30/23
Surgical Oncology Research Training Program
The goal of this grant is to train surgeons in cancer research and investigation. Dr. Chen serves as Associate Program Director.

Novo Nordisk – Chen (PI)
11/1/18-10/31/22
Medullary Thyroid Carcinoma Surveillance Study
This proposal is a national effort to understand the incidence and etiology of medullary thyroid cancer.

Completed Research Support

American Cancer Society MEN2 RSG – Chen (PI)
7/1/13-6/30/18
Notch signaling in Medullary Thyroid Cancer
This project focuses on translating Notch signaling in medullary thyroid cancer.

American Cancer Society – Chen (PI)
1/1/11-4/30/17
MEN2 Thyroid Cancer Professorship
This professor is to lead a consortium of medullary thyroid cancer investigators.

NIH/NCI RO1 CA121115 – Chen (PI)
5/1/09-4/30/15            
GSK3-beta Signaling in Medullary Thyroid Cancer

NIH/NCI RO1 CA109053 – Chen (PI)
8/1/06-7/31/12            
Regulating Neuroendocrine Phenotype in Cancer

NIH/NCI T32 CA090217-11 – Chen (PI) 
7/1/11-2/29/16     
Surgical Oncology Research Training Program

NIH/NIDDK T35 DK062709-06 – Chen (PI)
4/1/11-9/30/15     
Surgery Summer Research Experience for Medical Students

NIH/NCI RO1 CA121115-02S1 – Chen (PI)
5/18/10-2/1/13     
Minority Supplement for Yvette Carter

Doris Duke Charitable Foundation – Chen (PI) 
1/1/12-9/30/15     
Surgery Clinical Research Experiences for High School Students

NIH/GM R13 GM09523 – Chen (PI)
10/1/11-9/30/14     
AAS Courses to Increase Women and Minorities in Academic Surgery 

Doctors Cancer Foundation – Chen (PI)
7/1/07-6/30/12    
The Role of GSK3B in Carcinoid Cancers 

UWCCC/Wisconsin Discovery Institute – Chen (Co-PI)
7/1/12-6/30/15     
Co-delivery of siRNA and Anticancer Drug using Multifunctional Au NR-based Nanocarriers for Targeted Neuroendocrine Cancer Therapy

University of Wisconsin-Madison/Milwaukee – Chen (Co-PI)
8/1/12-7/30/14    
Novel Nanomedicines for Targeted Neuroendocrine Cancer Therapy

Novartis – Chen (Co-PI)
4/20/09-4/1/14    
A Phase II Clinical Trial of LBH589 for Thyroid Cancer

American College of Surgeons – Burke (PI) Chen (Mentor)
7/1/11-6/30/13
Targeting Notch in Medullary Thyroid Cancer

Novartis  – Chen (Co-PI) 
5/1/09-5/1/12    
A Phase II Clinical Trial of LBH589 for Gastrointestinal Neuroendocrine Cancers

NIH/NCI 8515 – Le Conte (PI), Chen (Co-PI)
4/20/09-5/1/12  
A Phase 1 Study of RO4929097 (NSC749225) in Combination with Capecitabine in Refractory Solid Tumors

NANeTS – Mazeh (PI) Chen (Mentor)
7/1/11-6/30/12
Notch 2 and 3 in Neuroendocrine Cancers 

Howard Hughes Medical Institute – Somnay (PI) Chen (Mentor)
7/1/11-6/30/12
Signaling in Carcinoid Cancers  

American College of Surgeons – Zarebczan (PI) Chen (Mentor)
7/1/09-06/30/11
Novel Therapeutic Strategies for Neuroendocrine Cancers 

Carcinoid Cancer Foundation – Chen (PI)
9/1/06-8/31/10 
Modulating Raf-1 Signaling in Carcinoid Cancer 

ACS George Clowes Memorial Award – Chen (PI)
7/1/04-6/30/10
Inhibition of Gastrointestinal Neuroendocrine Tumor Progression by Signal Transduction Pathways

NIH/NCI R21 CA117117 – Chen (PI)
6/15/07-5/31/10
Phase II Clinical Trial Utilizing Lithium for Patients with Neuroendocrine Tumors

Novartis – Chen (PI)
10/31/08-12/31/09
Combination Raf-1 activation and Octreotide in Neuroendocrine Cancer

Society of Surgical Oncology – Chen (PI)
6/1/07-6/30/09
Clinical Trial of GSK3B Inhibitors for Neuroendocrine Cancers

UW Comprehensive Cancer Center – Chen (PI)
7/1/07-6/30/09
The Role of GSK3B inhibition by Lithium as a Therapy for Patients with Advanced Medullary Thyroid Cancer

UW Comprehensive Cancer Center – Holen (PI) Chen (Co-PI)
7/1/07-6/30/09
A Preliminary Clinical Trial of Valproic Acid for Patients with Metastatic GI Neuroendocrine Cancers 

Howard Hughes Medical Institute – Cook (PI) Chen (Mentor) 
8/1/08-8/31/09
HDAC inhibitors and Notch1 

American College of Surgeons – Pitt (PI) Chen (Mentor)
7/1/07-6/30/09
Signaling Pathways in Gastrointestinal Neuroendocrine Tumors 

Association for Academic Surgery – Pinchot (PI) Chen (Mentor)
7/1/07-6/30/09
The Role of GSK3B Pathway in Gastrointestinal Neuroendocrine Tumors

Association for Academic Surgery – Greenblatt (PI) Chen (Mentor)
7/1/05-6/30/09
Notch1 Signaling in Gastrointestinal Neuroendocrine Tumors 

Howard Hughes Medical Institute – Adler (PI) Chen (Mentor)
7/1/07-6/30/08  
Dissecting the Mechanism of Notch1-mediated hormone Suppression in Gastrointestinal Neuroendocrine Cancer

American Cancer Society RSG TBE-108768 – Chen (PI)
1/1/05-12/31/08
Endocrine Differentiation and the Role of Notch1  

Vilas Foundation – Chen (PI)
7/1/06-6/30/08
Neuroendocrine Cancers: Signaling-based Therapies

NIH/NIDDK R21 DK066169 – Chen (PI)
2/1/04-1/31/07 
Novel Signaling Targets in GI Neuroendocrine Tumors

NIH/NIDDK R21 DK064735-01 – Chen (PI) 
7/1/03-6/30/05 
Signaling Pathways in Medullary Thyroid Cancer 

NIH/NIDDK R21 DK063015-01  – Chen (PI) 
1/1/03-12/31/04 
Notch1 Signaling and Gastrointestinal Neuroendocrine Tumors 

American Surgical Association Foundation – Chen (PI) 
7/1/02-6/30/04 
Gastrointestinal Neuroendocrine Tumors: A Possible Therapeutic Role for the ras/raf-1 signal transduction pathway 

Robert Draper Technology Innovation Fund – Chen (PI)
7/1/03-6/30/04 
A Novel Drug for Neuroendocrine Tumors 

Howard Hughes Medical Institute – Van Gompel (PI) Chen (Mentor)
7/1/03-6/30/04
The Role of Human Achaete-scute Homolog-1

University of Wisconsin Graduate School – Chen (PI) 
7/1/03-6/30/04
Notch1 Signaling in Gastrointestinal Tumors

Howard Hughes Medical Institute – Chen (PI)
7/1/01-6/30/03
A novel therapy for neuroendocrine tumors 

American Medical Association – Musunuru (PI) Chen (Mentor)
9/1/02-5/31/03 
Carcinoid Heart Disease 

University of Wisconsin Medical School – Chen (PI)
10/1/01-9/30/02
The role of insulin-like growth factor-I in GI carcinoid tumors 

Society of Surgical Oncology – Chen (PI)
1/1/01-12/31/01
The role of the ras/raf-1 signal transduction pathway in neuroendocrine tumor progression and metastases 

American Cancer Society IRG-58-011-44-04 – Chen (PI) 
11/1/00-10/31/01 
Raf-1 signaling in neuroendocrine tumors

NIH/NCI NRSA-CA67481 – Chen (PI) 
4/1/95-6/30/97
The transcriptional regulation of human achaete-scute homolog-1 

Howard Hughes Medical Institute – Chen (PI) 
9/1/90-8/31/91
HIV-1 regulatory proteins