COZI Trial
Principal Investigator: Drs. Katie Stone and Dan Buysse
Site-PI: Dr. S. Justin Thomas
Description: The “Cognitive Behavioral Therapy and Zolpidem/Trazodone for Insomnia in Rural Adults” (COZI) trial, funded by the Patient Centered Outcomes Research Institute (PCORI), is a multi-site comparative effectiveness study examining the impact of online cognitive behavioral therapy for insomnia (CBT-I) versus zolpidem or trazodone in rural adults. UAB is one of 8 sites, including the University of Pittsburgh, Pennsylvania State University, University of Virginia, University of Arizona, Oregon Health & Science University, University of Colorado, and University of Missouri.
DIPPER Study
Principal Investigator: Dr. S. Justin Thomas
Co-Investigator: Dr. Courtney Peterson, Dr. Karen Gamble, Dr. Paul Muntner, Dr. Orlando Gutierrez, Dr. Frank Scheer
Description: The “Central and Peripheral Circadian Mechanisms Underlying Non-Dipping Blood Pressure in African American/Black Adults” study is funded by the American Heart Association and seeks to examine central versus peripheral circadian contributions to blood pressure rhythms among normotensive African American/Black adults. In this study, we use a tightly controlled laboratory-based study called a constant routine protocol to directly examine circadian rhythms in humans by analyzing rhythms in melatonin and core body temperature.
HIPPI Study
Principal Investigator: Dr. Burel Goodin
Co-Investigator: Dr. S. Justin Thomas
Description: The “Impact of Insomnia on Pain, Physical Function, and Inflammation in HIV” study is funded by the National Heart, Lung, and Blood Institute (NHLBI) and examines inflammation and mitochondrial damage as mechanisms linking insomnia and pain in people living with HIV.
CRAVESS Study
Principal Investigators: Dr. Karen Cropsey and Dr. Karen Gamble
Co-Investigator: Dr. S. Justin Thomas
Description: The “Circadian and Sleep Mechanisms among Racial Groups for Nicotine Dependence, Craving, and Withdrawal” (CRAVESS) Study, funded by the National Institute on Drug Abuse (NIDA), examines race and sex differences in sleep and circadian contributions to cigarette smoking and withdrawal.
CARDIA Ancillary Study
Principal Investigators: Dr. Mercedes Carnethon and Dr. Kristin Knutson
Co-Investigator: Dr. S. Justin Thomas
Description: “Determinants and Cardiovascular Consequences of Disparities in Sleep and Circadian Rhythms between Black and White Adults” study, funded by NHLBI, is an ancillary study to the Coronary Artery Risk Development in Young Adults (CARDIA) Study.
JHS Ancillary Study
Principal Investigators: Dr. Rikki Tanner
Co-Investigator: Dr. S. Justin Thomas
Description: “Determining True versus Apparent Treatment-Resistant Hypertension among African Americans in the Jackson Heart Study”, funded by NHLBI, seeks to better understand factors, including sleep, that contribute
