Current Funding – Christian Faul, PhD
NIH/NIDDK – R01 DK125459
Role: PI
Period: 07/01/2020 – 04/30/2024
Direct costs per year: $374,870
Title: Hyperphosphatemia contributes to systemic inflammation and anemia in chronic kidney disease
Goals: To determine the direct effects of phosphate and FGF23 on hepatocytes and whether the blockade of these newly identified actions protects mouse models of CKD from anemia and increases muscle strength.
NIH/NHLBI – R01HL145528
Role: MPI with Dr. Kenneth White
Period: 02/01/2019 – 01/31/2023
Direct costs per year: $474,468
Title: Changes in phosphate metabolism cause pathologic cardiac remodeling in chronic kidney disease (CKD)
Goals: To analyze the crosstalk between FGF23/FGFR4, Klotho and Vitamin D signaling in the regulation of cardiac remodeling in CKD using cell culture and transgenic mouse models.
NIH/NIDDK – R25 DK115353 – Director: Dr. Jennifer Pollock
Role: Associate Program Director
Period: 09/21/2018 – 07/31/2023
Direct costs per year: $100,000
Title: Kidney Undergraduate Research Experience (KURE)
Goals: To engage undergraduate students with an interest in biomedical sciences from throughout the US in kidney-related research. Over the course of the 10 week program, the students are matched with an experienced mentor at UAB, join his/her laboratory to conduct basic research experiments and attend various seminars and workshops.
Current Funding – Members of Dr. Faul’s Group
NIH/NIDCR – T90 DART – Predoctoral Fellowship
PI: Kylie Heitman
Dr. Faul’s role: Sponsor and the thesis mentor of the PhD student at UAB
Period: 07/01/2020 – 06/30/2023
Direct costs per year: $30,000
Title: Elevated FGF23 contributes to skeletal muscle wasting in the context of chronic kidney disease
Goals: To study bone and skeletal muscle biology. The student will determine whether FGF23 can directly target skeletal muscle cells and thereby contribute to CKD-associated muscle atrophy and wasting, using primary cell culture and animal models.
