59: Reddi KK, Chava S, Chabattula SC, Edwards YJK, Singh K, Gupta R. (2024). ASAH1 facilitates TNBC by DUSP5 suppression-driven activation of MAP kinase pathway and represents a therapeutic vulnerability. Cell Death Dis. 15(6):452. PMID: 38926346.
58: Smith AO, Frantz WT, Preval KM, Edwards YJK, Ceol CJ, Jonassen JA, Pazour GJ (2023). The Tumor-Associated Calcium Signal Transducer 2 (TACSTD2) oncogene is upregulated in pre-cystic epithelial cells revealing a new target for polycystic kidney disease. medRxiv. 2023 Dec 4:2023.12.04.23299387.
57: Malvi P, Chava S, Cai G, Hu K, Zhu LJ, Edwards YJK, Green MR, Gupta R, Wajapeyee N. (2023). HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B. Cell Rep Med. 4(11):101285.
56: Salinas EA, Macauley V, Keeling KM, Edwards YJK. (2023). Discovery of dysregulated circular RNAs in whole blood transcriptomes from cystic fibrosis patients – implication of a role for cellular senescence in cystic fibrosis. J Cyst Fibros. 22(4):683-693.
55: Bugide S, Edwards YJK, Gupta R, Green MR, Wajapeyee N. (2023). CBX5 loss drives EGFR inhibitor resistance and results in therapeutically actionable vulnerabilities inhibitor. Proc Natl Acad Sci U S A. 120(4):e2218118120.
54: Dutta R, Guruvaiah P, Reddi KK, Bugide S, Reddy Bandi DS, Edwards YJK, Singh K, Gupta R. (2022). UBE2T promotes breast cancer tumor growth by suppressing DNA replication stress. NAR Cancer. 4(4):zcac035.
53: Vernia S, Lee A, Kennedy NJ, Han MS, Isasa M, Cavanagh-Kyros J, Roy A, Syed A, Chaudhry S, Edwards YJK, Gygi SP, Gao G, Davis RJ. (2022). Phosphorylation of RXRα mediates the effect of JNK to suppress hepatic FGF21 expression and promote metabolic syndrome. Proc Natl Acad Sci U S A. 119(44):e2210434119.
52: Hussain SS, Edwards YJK, Libby EF, Stanford D, Byzek SA, Sin DD, McDonald ML, Raju SV, Rowe SM. (2022). Comparative transcriptomics in human COPD reveals dysregulated genes uniquely expressed in ferrets. Respir Res. 23(1):277.
51: Reddi KK, Guruvaiah P, Edwards YJK, Gupta R. (2022). Changes in the Transcriptome and Chromatin Landscape in BRAFi-Resistant Melanoma Cells. Front Oncol. 12:937831.
50: Clarke AM, Huffines AK, Edwards YJK, Petit CM, Schneider DA. (2021). Defining the Influence of the A12.2 Subunit on Transcription Elongation and Termination by RNA Polymerase I In Vivo. Genes (Basel). 12(12):1939.
49: Chava S, Bugide S, Edwards YJK, Gupta R. (2021). Disruptor of telomeric silencing 1-like promotes ovarian cancer tumor growth by stimulating pro-tumorigenic metabolic pathways and blocking apoptosis. Oncogenesis 10(7):48.
48: Huffines AK, Edwards YJK, Schneider DA. (2021). Spt4 Promotes Pol I Processivity and Transcription Elongation. Genes (Basel). 12(3):413.
47: Cevallos RR, Edwards YJK, Parant JM, Yoder BK, Hu K. (2020). Human transcription factors responsive to initial reprogramming predominantly undergo legitimate reprogramming during fibroblast conversion to iPSCs. Sci Rep. 10(1):19710.
46: Britain CM, Bhalerao N, Silva AD, Chakraborty A, Buchsbaum DJ, Crowley MR, Crossman DK, Edwards YJK, Bellis SL. (2020). Glycosyltransferase ST6Gal-I promotes the epithelial to mesenchymal transition in pancreatic cancer cells. J Biol Chem. 296:100034.
45: VanWinkle PE, Parish F, Edwards YJK, Sztul E. (2020). JAGN1, tetraspanins, and Erv proteins: is common topology indicative of common function in cargo sorting? Am J Physiol Cell Physiol. 319(4):C667-C674.
44: Nie Y, Yu S, Li Q, Nirala NK, Amcheslavsky A, Edwards YJK, Shum PW, Jiang Z, Wang W, Zhang B, Gao N, Ip YT. (2019). Oncogenic Pathways and Loss of the Rab11 GTPase Synergize To Alter Metabolism in Drosophila. Genetics. 212(4):1227-1239.
43: Jangalwe S, Kapoor VN, Xu J, Girnius N, Kennedy NJ, Edwards YJK, Welsh RM, Davis RJ, Brehm MA. (2019). Cutting Edge: Early Attrition of Memory T Cells during Inflammation and Costimulation Blockade Is Regulated Concurrently by Proapoptotic Proteins Fas and Bim. J Immunol. 202(3):647-651.
42: Shen Y, Cohen JL, Nicoloro SM, Kelly M, Yenilmez B, Henriques F, Tsagkaraki E, Edwards YJK, Hu X, Friedline RH, Kim JK, Czech MP. (2018). CRISPR-delivery particles targeting nuclear receptor-interacting protein 1 Nrip1 in adipose cells to enhance energy expenditure. J Biol Chem. 2018 Nov 2;293(44):17291-17305.
41: Girnius N, Edwards YJ, Garlick DS, Davis RJ. (2018). The cJUN NH2-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation. Elife. 7:e36389.
40: Girnius N, Edwards YJK, Davis RJ. (2018). The cJUN NH2-terminal kinase (JNK) pathway contributes to mouse mammary gland remodeling during involution. Cell Death Differ. 2018 25(9):1702-1715.
39: Venkatesan AM, Vyas R, Gramann AK, Dresser K, Gujja S, Bhatnagar S, Chhangawala S, Gomes CBF, Xi HS, Lian CG, Houvras Y, Edwards YJK, Deng A, Green M, Ceol CJ. (2018). Ligand-activated BMP signaling inhibits cell differentiation and death to promote melanoma. J Clin Invest. 128(1):294-308.
38: Sanchez-Gurmaches J, Tang Y, Jespersen NZ, Wallace M, Martinez Calejman C, Gujja S, Li H, Edwards YJK, Wolfrum C, Metallo CM, Nielsen S, Scheele C, Guertin DA. (2018). Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis. Cell Metab. 27(1):195-209.e6.
37: Fitzgibbons TP, Edwards YJK, Shaw P, Iskandar A, Ahmed M, Bote J, Shah T, Sinha S, Gerszten RE, Keaney JF Jr, Zile MR, Aurigemma GP. (2017). Activation of Inflammatory and Pro-Thrombotic Pathways in Acute Stress Cardiomyopathy. Front Cardiovasc Med. 4:49.
36: Vernia S, Edwards YJ, Han MS, Cavanagh-Kyros J, Barrett T, Kim JK, Davis RJ. (2016). An alternative splicing program promotes adipose tissue thermogenesis. Elife. 5:e17672.
35: Mansur F, Ivshina M, Gu W, Schaevitz L, Stackpole E, Gujja S, Edwards YJ, Richter JD. (2016). Gld2-catalyzed 3′ monoadenylation of miRNAs in the hippocampus has no detectable effect on their stability or on animal behavior. RNA. 22(10):1492-9.
34: Smulan LJ, Ding W, Freinkman E, Gujja S, Edwards YJK, Walker AK. (2016). Cholesterol-Independent SREBP-1 Maturation Is Linked to ARF1 Inactivation. Cell Rep. 16(1):9-18.
33: Roth Flach RJ, Guo CA, Danai LV, Yawe JC, Gujja S, Edwards YJ, Czech MP. (2016). Endothelial Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Is Critical for Lymphatic Vascular Development and Function. Mol Cell Biol. 36(12):1740-9.
32: Diaz-Horta O, Duman D, Foster J 2nd, Sırmacı A, Gonzalez M, Mahdieh N, Fotouhi N, Bonyadi M, Cengiz FB, Menendez I, Ulloa RH, Edwards YJ, Züchner S, Blanton S, Tekin M. (2012). Whole-exome sequencing efficiently detects rare mutations in autosomal recessive nonsyndromic hearing loss. PLoS One. 7(11):e50628.
31: Yariz KO, Duman D, Zazo Seco C, Dallman J, Huang M, Peters TA, Sirmaci A, Lu N, Schraders M, Skromne I, Oostrik J, Diaz-Horta O, Young JI, Tokgoz-Yilmaz S,Konukseven O, Shahin H, Hetterschijt L, Kanaan M, Oonk AM, Edwards YJ, Li H, Atalay S, Blanton S, Desmidt AA, Liu XZ, Pennings RJ, Lu Z, Chen ZY, Kremer H, Tekin M. (2012). Mutations in OTOGL, encoding the inner ear protein otogelin-like, cause moderate sensorineural hearing loss. Am J Hum Genet. 91(5):872-82.
30: Sirmaci A, Edwards YJ, Akay H, Tekin M. (2012). Challenges in whole exome sequencing: an example from hereditary deafness. PLoS One 7(2):e32000.
29: Hedges DJ, Guettouche T, Yang S, Bademci G, Diaz A, Andersen A, Hulme WF, Linker S, Mehta A, Edwards YJ, Beecham GW, Martin ER, Pericak-Vance MA, Zuchner S, Vance JM, Gilbert JR. (2011). Comparison of three targeted enrichment strategies on the SOLiD sequencing platform. PLoS One. 6(4):e18595.
28: Edwards YJ, Beecham GW, Scott WK, Khuri S, Bademci G, Tekin D, Martin ER, Jiang Z, Mash DC, ffrench-Mullen J, Pericak-Vance MA, Tsinoremas N, Vance JM. (2011). Identifying consensus disease pathways in Parkinson’s disease using an integrative systems biology approach. PLoS One 6(2):e16917.
27: Züchner S, Dallman J, Wen R, Beecham G, Naj A, Farooq A, Kohli MA, Whitehead PL, Hulme W, Konidari I, Edwards YJ, Cai G, Peter I, Seo D, Buxbaum JD, Haines JL, Blanton S, Young J, Alfonso E, Vance JM, Lam BL, Peričak-Vance MA. (2011). Whole-exome sequencing links a variant in DHDDS to retinitis pigmentosa. Am J Hum Genet. 88(2):201-6.
26: Montenegro G, Powell E, Huang J, Speziani F, Edwards YJ, Beecham G, Hulme W, Siskind C, Vance J, Shy M, Züchner S. (2011). Exome sequencing allows for rapid gene identification in a Charcot-Marie-Tooth family. Ann Neurol. 69(3):464-70.
25: Williams SL, Huang J, Edwards YJ, Ulloa RH, Dillon LM, Prolla TA, Vance JM, Moraes CT, Züchner S. (2011). The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimers. Cell Metab. 12(6):675-82.
24: Cengiz FB, Duman D, Sirmaci A, Tokgöz-Yilmaz S, Erbek S, Oztürkmen-Akay H, Incesulu A, Edwards YJ, Ozdag H, Liu XZ, Tekin M. (2010). Recurrent and private MYO15A mutations are associated with deafness in the Turkish population. Genet Test Mol Biomarkers 14(4):543-50.
23: Edwards YJ, Lobley AE, Pentony MM, Jones DT. (2010). Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data. Genome Biol. 10(5):R50.
22: Edwards YJ, Bryson K, Jones DT. (2008). A meta-analysis of microarray gene expression in mouse stem cells: redefining stemness. PLoS One 3(7):e2712
21: Cottage A, Edwards YJ, Elgar G. (2001). SAND, a new protein family: from nucleic acid to protein structure and function prediction. Comp Funct Genomics. 2(4):226-35.
20: Ikeda D, Ono Y, Snell P, Edwards YJ, Elgar G, Watabe S. (2007). Divergent evolution of the myosin heavy chain gene family in fish and tetrapods: evidence from comparative genomic analysis. Physiol Genomics 32(1):1-15.
19: Edwards YJ, Walter K, McEwen G, Vavouri T, Kelly KA, Abnizova I, Woolfe A, Goode DK, Goodson M, North P, Snell P, Callaway H, Smith SF, Gilks WR, Cooke JE, Elgar G. (2006). Characterisation of conserved non-coding sequences in vertebrate genomes using bioinformatics, statistics and functional studies. Comp Biochem Physiol Part D Genomics Proteomics 1(1):46-58.
18: Cottage A, Mullan L, Portela MB, Hellen E, Carver T, Patel S, Vavouri T, Elgar G, Edwards YJ. (2004). Molecular characterisation of the SAND protein family: a study based on comparative genomics, structural bioinformatics and phylogeny. Cell Mol Biol Lett. 9(4A):739-53.
17: Woolfe A, Goodson M, Goode DK, Snell P, McEwen GK, Vavouri T, Smith SF, North P, Callaway H, Kelly K, Walter K, Abnizova I, Gilks W, Edwards YJ, Cooke JE, Elgar G. (2005). Highly conserved non-coding sequences are associated with vertebrate development. PLoS Biol. 3(1):e7.
16: Halling-Brown M, Sansom C, Moss DS, Elgar G, Edwards YJ. (2004). A Fugu-Human Genome Synteny Viewer: web software for graphical display and annotation reports of synteny between Fugu genomic sequence and human genes. Nucleic Acids Res. 32(8):2618-22.
15: Clark MS, Edwards YJ, Peterson D, Clifton SW, Thompson AJ, Sasaki M, Suzuki Y, Kikuchi K, Watabe S, Kawakami K, Sugano S, Elgar G, Johnson SL. (2003). Fugu ESTs: new resources for transcription analysis and genome annotation. Genome Res 13(12):2747-53.
14: Cottage AJ, Edwards YJ, Elgar G. (2003). AP1 genes in Fugu indicate a divergent transcriptional control to that of mammals. Mamm Genome. 14(8):514-25.
13: Edwards YJ, Carver TJ, Vavouri T, Frith M, Bishop MJ, Elgar G. (2003) Theatre: A software tool for detailed comparative analysis and visualization of genomic sequence. Nucleic Acids Res. 31(13):3510-7.
12: Edwards YJ, Cottage A. (2003). Bioinformatics methods to predict protein structure and function. A practical approach. Mol Biotechnol. 23(2):139-66.
11: Sambrook JG, Russell R, Umrania Y, Edwards YJ, Campbell RD, Elgar G, Clark MS. (2002). Fugu orthologues of human major histocompatibility complex genes: a genomesurvey. Immunogenetics 54(6):367-80.
10: Aparicio S, Chapman J, Stupka E, Putnam N, Chia JM, Dehal P, Christoffels A, Rash S, Hoon S, Smit A, Gelpke MD, Roach J, Oh T, Ho IY, Wong M, Detter C, Verhoef F, Predki P, Tay A, Lucas S, Richardson P, Smith SF, Clark MS, Edwards YJ, Doggett N, Zharkikh A, Tavtigian SV, Pruss D, Barnstead M, Evans C, Baden H, Powell J, Glusman G, Rowen L, Hood L, Tan YH, Elgar G, Hawkins T, Venkatesh B, Rokhsar D, Brenner S. (2002). Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes. Science 297(5585):1301-10.
9: Edwards YJ, Cottage A. (2001). Prediction of protein structure and function by using bioinformatics. Methods Mol Biol. 175:341-75.
8: Edwards YJ, Brocklehurst SM. (2001). Finding genes in genomic nucleotide sequences by using bioinformatics. Methods Mol Biol. 175:235-47.
7: Perkins SJ, Hinshelwood J, Edwards YJ, Jenkins PV. (1999). Structural and functional modelling of von Willebrand factor type A domains in complement and coagulation. Biochem Soc Trans. 27(6):815-20.
6: Hinshelwood J, Spencer DI, Edwards YJ, Perkins SJ. (1999). Identification of the C3b binding site in a recombinant vWF-A domain of complement factor B by surface-enhanced laser desorption-ionisation affinity mass spectrometry and homology modelling: implications for the activity of factor B. J Mol Biol. 294(2):587-99.
5: Elgar G, Clark MS, Meek S, Smith S, Warner S, Edwards YJ, Bouchireb N, Cottage A, Yeo GS, Umrania Y, Williams G, Brenner S. (1999). Generation and analysis of 25 Mb of genomic DNA from the pufferfish Fugu rubripes by sequence scanning. Genome Res. 9(10):960-71.
4: Clark MS, Edwards YJ, McQueen HA, Meek SE, Smith S, Umrania Y, Warner S, Williams G, Elgar G. (1999). Sequence scanning chicken cosmids: a methodology for genome screening. Gene 227(2):223-30.
3: Edwards YJ, Elgar G, Clark MS, Bishop MJ. (1998). The identification and characterization of microsatellites in the compact genome of the Japanese pufferfish, Fugu rubripes: perspectives in functional and comparative genomic analyses. J Mol Biol. 278(4):843-54.
2: Edwards YJ, Perkins SJ. (1996). Assessment of protein fold predictions from sequence information: the predicted alpha/beta doubly wound fold of the von Willebrand factor type A domain is similar to its crystal structure. J Mol Biol. 260(2):277-85.
1: Edwards YJ, Perkins SJ. (1995). The protein fold of the von Willebrand factor type A domain is predicted to be similar to the open twisted beta-sheet flanked by alpha-helices found in human ras-p21. FEBS Lett. 358(3):283-6.
