November 7, 2022

New research articles published with members of the CBRL.

Dutta R, Guruvaiah P, Reddi KK, Bugide S, Reddy Bandi DS, Edwards YJK, Singh K, Gupta R. UBE2T promotes breast cancer tumor growth by suppressing DNA replication stress. NAR Cancer 4(4):zcac035.

Vernia S, Lee A, Kennedy NJ, Han MS, Isasa M, Cavanagh-Kyros J, Roy A, Syed A, Chaudhry S, Edwards YJK, Gygi SP, Gao G, Davis RJ. Phosphorylation of RXRα mediates the effect of JNK to suppress hepatic FGF21 expression and promote metabolic syndrome. Proc Natl Acad Sci U S A. 119(44):e2210434119.

Hussain SS, Edwards YJK, Libby EF, Stanford D, Byzek SA, Sin DD, McDonald ML, Raju SV, Rowe SM. Comparative transcriptomics in human COPD reveals dysregulated genes uniquely expressed in ferrets. Respir Res. 23(1):277.

Reddi KK, Guruvaiah P, Edwards YJK, Gupta R. Changes in the Transcriptome and Chromatin Landscape in BRAFi-Resistant Melanoma Cells. Front Oncol. 12:937831.

July 12, 2022

Dr Yvonne Edwards is on the Editorial Board and served as one of three Associate Editors working with the Editor-in-Chief for Briefings in Bioinformatics. According to the Journal Citation Reports, the 2021 Journal Impact Factor for Briefings in Bioinformatics is 13.994 and ranks #1 out of 57 journals in the category of Mathematical and Computational Biology.

July 20, 2021

New research articles published with members of the CBRL.

Chava S, Bugide S, Edwards YJK, Gupta R. Disruptor of telomeric silencing 1-like promotes ovarian cancer tumor growth by stimulating pro-tumorigenic metabolic pathways and blocking apoptosis. Oncogenesis. 10(7):48.

Huffines AK, Edwards YJK, Schneider DA. Spt4 Promotes Pol I Processivity and Transcription Elongation. Genes (Basel). 12(3):413.

November 16, 2020

New research articles published with members of the CBRL.

Britain CM, Bhalerao N, Silva AD, Chakraborty A, Buchsbaum DJ, Crowley MR,Crossman DK, Edwards YJK, Bellis SL. (2020). Glycosyltransferase ST6Gal-I promotes the epithelial to mesenchymal transition in pancreatic cancer cells. J Biol Chem. doi: 10.1074/jbc.RA120.014126.

Cevallos RR, Edwards YJK, Parant JM, Yoder BK, Hu K. (2020). Human transcription factors responsive to initial reprogramming predominantly undergo legitimate reprogramming during fibroblast conversion to iPSCs. Sci Rep. 10(1):19710. doi: 10.1038/s41598-020-76705-y.

VanWinkle PE, Parish F, Edwards YJK, Sztul E. (2020). JAGN1, tetraspanins, and Erv proteins: is common topology indicative of common function in cargo sorting? Am J Physiol Cell Physiol. 319(4):C667-C674. doi:10.1152/ajpcell.00436.2019.

September 23, 2020

A Bioinformatics Post-Doctoral Position is available in the Collaborative Bioinformatics Research Lab.

April 30, 2020

UAB IT Research Computing announcement (see link here) describes Globus Share Technology enabling remote collaboration at UAB School of Medicine. Dr Yvonne Edwards (Director, Collaborative Bioinformatics Research Lab) and Dr Narendra Wajapeyee (Professor, Vice Chair for Research) are featured in the announcement utilizing Globus Share for remote collaboration. UAB IT Research Computing provided modern technology enabling remote data sharing capabilities and collaboration for big data research. Globus Share proved to be an important collaborative tool during the mandatory lockdown of the UAB campus due to the COVID-19 pandemic.

April 2, 2020

New grants awarded with support from the Collaborative Bioinformatics Research Lab. Dr Kim Keeling (Principal Investigator) and Dr Edwards (Co-Principal Investigator) won a grant award for $500,000 direct costs (over 2 years) for Cystic Fibrosis research “Investigating Nonsense-Mediated mRNA Decay (NMD) as a Therapeutic Target”. One of the goals is to examine how CFTR premature termination codon containing mRNAs are targeted for NMD, allowing us to identify specific and safe NMD targets for the development of new treatments for Cystic Fibrosis patients who carry a nonsense mutation. This is a patient subgroup for which no therapies are currently available. The main goal of the research is to determine whether conditions can be achieved to inhibit NMD so as to raise CFTR mRNA levels without causing toxic side effects.