The Alabama-to-Zambia Clinical Trials Unit (A-toZ CTU) is committed to addressing the HIV epidemic in the Southeastern US, where HIV incidence remains the highest domestically, and in Sub-Saharan Africa where the global burden of HIV is highest. We have an integrated leadership group from the Alabama Clinical Research Site (CRS) and CIDRZ CRS, whose members are committed to advancing science to improve the quality and longevity of lives of those living with HIV, ending the HIV epidemic, and eliminating disparities for people living with HIV (PLWH).