Mutations in LRRK2 are the most common genetic cause of PD. Disease-causing mutations in LRRK2 have been shown to increase the kinase activity of LRRK2. One key set of proteins that interact with LRRK2 are the 14-3-3 proteins, and this interaction is disrupted in several disease-causing mutations of LRRK2. We are investigating how the 14-3-3 proteins can regulate the function and toxicity of LRRK2.