Rakesh Patel Lab
Our laboratory aims to understand the mechanisms that link perturbations in redox signaling to the development of inflammatory disease, and using these insights to develop and test therapeutics.
Current disease and focus areas include:
- Acute lung injury mediated by products of hemolysis in Sepsis, after exposure to inhaled toxicants, or after transfusion of blood products in Trauma patients
- Determine the mechanisms by which Red Blood Cell (RBC) destruction leads to endothelial dysfunction in acute and chronic inflammatory diseases
- Determine the role of endothelial redox signaling to control N-glycans and regulate immune cell trafficking in atherosclerosis
Mission
- To delineate the mechanisms that link perturbations in redox signaling to the development of inflammatory disease.
- To develop a welcoming environment that enables cutting edge collaborative research, training and professional / personal development.
Research Overview
Redox biology is a broad and multidisciplinary area of science that encompasses physiologic, pathophysiologic and therapeutic arenas. Also referred to by the terms ‘oxidative stress’ or ‘free radical biology’, perturbations in redox homeostasis has been implicated in all major diseases, in multiple cell and organ systems and across prokaryotic and eukaryotic systems. Moreover, redox biology is at the interface of how the environment and lifestyle choices affect health and disease.
With this broad background, our laboratory’s goal is to understand the biochemical and molecular mechanisms underlying perturbations in redox signaling to development of inflammatory disease, and then using these insights to develop and test therapeutics. We employ an interdisciplinary approach encompassing test-tube biochemistry, cell and animal models of disease, therapeutics and translational / clinical studies.
Link to lab publications: http://www.ncbi.nlm.nih.gov/sites/myncbi/1FUJ7Giwtx-Aq/bibliography/40098769/public/?sort=date&direction=descending
