Find the PDFs for all of our research here!
2024
Vukadin L, Park B, Mohamed M, Li H, Elkholy A, Torrelli-Diljohn A, Kim JH, Jeong K, MurphyJM, Harvey CA, Dunlap S, Gehrs L, Kim HG, Lee SN, Sanford D, Barrington RA, Foote JB, Sorace AG, Welner RS, Hildreth BE, Lim SS, and Ahn EE.
A mouse model of Zhu-Tokita-Takenouchi-Kim syndrome reveals indispensable SON functions in organ development and hematopoiesis.
JCI Insight (2024). Jan 30;9(5):e175053
2023
Murphy JM, Jeong K, Tran D, Cioffi DL, Campbell PM, Kim J, Jo H, Ahn EYE, Lim STS.
Nuclear FAK in Endothelium: An Intrinsic Inhibitor of NF-kB Activation in Atherosclerosis
Atherosclerosis (2023). July 25;379:117189. Doi:10.1016/j.atherosclerosis.2023.117189
2022
Nuclear focal adhesion kinase induces APC/C activator protein CDH1-mediated cyclin-dependent kinase 4/6 degradation and inhibits melanoma proliferation. Journal of Biological Chemistry. 298. 2022
10.1016/j.jbc.2022.102013
FAK in the nucleus prevents VSMC proliferation by promoting p27 and p21 expression via Skp2 degradation. Cardiovascular Research. 118:1150-1163. 2022
10.1093/cvr/cvab132
LED Light-Induced ROS Differentially Regulates Focal Adhesion Kinase Activity in HaCaT Cell Viability. Current Issues in Molecular Biology. 44:1235-1246. 2022
10.3390/cimb44030082
Cytotoxic tau released from lung microvascular endothelial cells upon infection with Pseudomonas aeruginosa promotes neuronal tauopathy. Journal of Biological Chemistry. 298. 2022
10.1016/j.jbc.2021.101482
2021
Fak activation promotes smc dedifferentiation via increased dna methylation in contractile genes. Circulation Research. 129:E215-E233. 2021
10.1161/CIRCRESAHA.121.319066
SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity. Nature Communications. 12. 2021
10.1038/s41467-021-25892-x 
EphA2 signaling within integrin adhesions regulates fibrillar adhesion elongation and fibronectin deposition. Matrix Biology. 103-104:1-21. 2021
10.1016/j.matbio.2021.09.001
SON inhibits megakaryocytic differentiation via repressing RUNX1 and the megakaryocytic gene expression program in acute megakaryoblastic leukemia. Cancer Gene Therapy. 28:1000-1015. 2021
10.1038/s41417-020-00262-9
Focal Adhesion Kinase Activity and Localization is Critical for TNF-α-Induced Nuclear Factor-κB Activation. Inflammation. 44:1130-1144. 2021
10.1007/s10753-020-01408-5
2020
Targeting focal adhesion kinase in cancer cells and the tumor microenvironment. Experimental and Molecular Medicine. 52:877-886. 2020
10.1038/s12276-020-0447-4
FAK Family Kinases in Vascular Diseases.. International Journal of Molecular Sciences. 21. 2020
10.3390/ijms21103630
2019
FAK and Pyk2 activity promote TNF-α and IL-1β-mediated pro-inflammatory gene expression and vascular inflammation. Scientific Reports. 9. 2019
10.1038/s41598-019-44098-2
Hypoxia induces cancer cell-specific chromatin interactions and increases MALAT1 expression in breast cancer cells. Journal of Biological Chemistry. 294:11213-11224. 2019
10.1074/jbc.RA118.006889
SON haploinsufficiency causes impaired pre-mRNA splicing of CAKUT genes and heterogeneous renal phenotypes. Kidney International. 95:1494-1504. 2019
10.1016/j.kint.2019.01.025
FAK inhibition reduces metastasis of α4 integrin-expressing melanoma to lymph nodes by targeting lymphatic VCAM-1 expression. Biochemical and Biophysical Research Communications. 509:1034-1040. 2019
10.1016/j.bbrc.2019.01.050
A quantitative method to measure low levels of ros in nonphagocytic cells by using a chemiluminescent imaging system. Oxidative Medicine and Cellular Longevity. 2019. 2019
10.1155/2019/1754593
Nuclear focal adhesion kinase controls vascular smooth muscle cell proliferation and neointimal hyperplasia through GATA4-mediated cyclin D1 transcription. Circulation Research. 125:152-166. 2019
10.1161/CIRCRESAHA.118.314344
2016
De Novo Mutations in SON Disrupt RNA Splicing of Genes Essential for Brain Development and Metabolism, Causing an Intellectual-Disability Syndrome. American Journal of Human Genetics. 99:711-719. 2016
10.1016/j.ajhg.2016.06.029
Regulation of mitochondrial functions by protein phosphorylation and dephosphorylation. Cell & Bioscience. 6. 2016
10.1186/s13578-016-0089-3
SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes. Molecular Cell. 61:859-873. 2016
10.1016/j.molcel.2016.02.024
FAK and Pyk2 in disease. Frontiers in Biology. 11. 2016
10.1007/s11515-016-1384-4
2015
Understanding the Roles of FAK in Cancer: Inhibitors, Genetic Models, and New Insights. Journal of Histochemistry and Cytochemistry: imaging the spectrum of cell biology. 63:114-128. 2015
10.1369/0022155414561498
2013
Nuclear FAK: A new mode of gene regulation from cellular adhesions. Molecules and Cells. 36:1-6. 2013
10.1007/s10059-013-0139-1
2012
Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells. Journal of Cell Science. 125:5960-5973. 2012
10.1242/jcs.100586
Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression. The Journal of Cell Biology. 197:907-919. 2012
10.1083/jcb.201109067
Rgnef (p190RhoGEF) knockout inhibits RhoA activity, focal adhesion establishment, and cell motility downstream of integrins. PLoS One. 7. 2012
10.1371/journal.pone.0037830
EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1. PLoS One. 7. 2012
10.1371/journal.pone.0036753
FAK promotes recruitment of talin to nascent adhesions to control cell motility. The Journal of Cell Biology. 196:387. 2012
10.1083/jcb.2011080781963c
VEGF-Induced Vascular Permeability Is Mediated by FAK. Developmental Cell. 22:146-157. 2012
10.1016/j.devcel.2011.11.002
FAK promotes recruitment of talin to nascent adhesions to control cell motility. The Journal of Cell Biology. 196:223-232. 2012
10.1083/jcb.201108078
2011
P190RhoGEF (Rgnef) promotes colon carcinoma tumor progression via interaction with focal adhesion kinase. Cancer Research. 71:360-370. 2011
10.1158/0008-5472.CAN-10-2894
2010
Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation. Journal of Biological Chemistry. 285:21526-21536. 2010
10.1074/jbc.M110.129999
PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biology and Therapy. 9:762-775. 2010
10.4161/cbt.9.10.11434
Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival. Journal of Biological Chemistry. 285:1743-1753. 2010
10.1074/jbc.M109.064212
Erratum to “A novel strong promoter of the groEx operon of symbiotic bacteria in Amoeba proteus” [Gene 148 (1994) 43-49] (DOI:10.1016/0378-1119(94)90231-3). Gene. 449:118. 2010
10.1016/j.gene.2009.09.012
2009
Erratum: A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells (Journal of Cell Science vol. 122 (1852-1862)). Journal of Cell Science. 122:3005. 2009
10.1242/jcs.058487
A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells. Journal of Cell Science. 122:1852-1862. 2009
10.1242/jcs.046870
2008
FERM control of FAK function: Implications for cancer therapy. Cell Cycle. 7:2306-2314. 2008
10.4161/cc.6367
FAK nuclear export signal sequences. FEBS Letters. 582:2402-2406. 2008
10.1016/j.febslet.2008.06.004
Nuclear FAK Promotes Cell Proliferation and Survival through FERM-Enhanced p53 Degradation. Molecular Cell. 29:9-22. 2008
10.1016/j.molcel.2007.11.031
2007
Tumor necrosis factor-α stimulates focal adhesion kinase activity required for mitogen-activated kinase-associated interleukin 6 expression. Journal of Biological Chemistry. 282:17450-17459. 2007
10.1074/jbc.M610672200
Focal adhesion kinase controls ph-dependent epidermal barrier homeostasis by regulating actin-directed Na+/H+ exchanger 1 plasma membrane localization. American Journal of Pathology. 170:2055-2067. 2007
10.2353/ajpath.2007.061277
2006
Analyzing FAK and Pyk2 in early integrin signaling events.. Current protocols in cell biology / editorial board, Juan S. Bonifacino … [et al.]. Chapter 14. 2006
2005
Integrin α4β1 promotes focal adhesion kinase-independent cell motility via α4 cytoplasmic domain-specific activation of c-Src. Molecular and Cellular Biology. 25:9700-9712. 2005
10.1128/MCB.25.21.9700-9712.2005
2004
Calmodulin binding to the Fas death domain: Regulation by Fas activation. Journal of Biological Chemistry. 279:5661-5666. 2004
10.1074/jbc.M311040200
2003
Direct binding of syndecan-4 cytoplasmic domain to the catalytic domain of protein kinase Cα (PKCα) increases focal adhesion localization of PKCα. Journal of Biological Chemistry. 278:13795-13802. 2003
10.1074/jbc.M208300200
2002
Regulation of inositol phospholipid binding and signaling through syndecan-4. Journal of Biological Chemistry. 277:49296-49303. 2002
10.1074/jbc.M209679200
1998
Syndecan-4 proteoglycan cytoplasmic domain and phosphatidylinositol 4,5- bisphosphate coordinately regulate protein kinase C activity. Journal of Biological Chemistry. 273:10624-10629. 1998
10.1074/jbc.273.17.10624
1994
A novel strong promoter of the groEx operon of symbiotic bacteria in Amoeba proteus. Gene. 148:43-49. 1994
10.1016/0378-1119(94)90231-3
