Welcome to The Telomerase Regulation Lab at UAB
in the Department of Biochemistry and Molecular Genetics
and the O’Neal Comprehensive Cancer Center

The Telomerase Regulation Lab focuses on three interrelated topics. The first focus is on telomerase in cancer. Another focus is comparing telomerase regulation in stem cells, differentiated cells, and during cellular reprogramming. The third focus is determining how telomerase expression impacts cellular function in different contexts.

Currently, we work on three main aspects of telomerase biology:

• Therapeutic vulnerabilities of cancers with TERT promoter mutations

• Interactions that regulate TERT transcription

• Biological consequences of telomerase-mediated telomere length regulation