Holder received her medical degree from Baylor College of Medicine, where she completed an HHMI Medical Student Research Fellowship, and completed her general surgery residency at Washington University in St. Louis, where she served as one of two Walter F. Ballinger administrative chief residents and was a finalist for the ACS Jameson L. Chassin, M.D., FACS Award for Professionalism. She completed her fellowship in Complex General Surgical Oncology at UT MD Anderson Cancer Center and was awarded the Daniel Benedict Gazan Fellowship in Sarcoma Research.

Through her secondary appointment in the Department of Nanomedicine at the Houston Methodist Research Institute, she was awarded a High-Impact High-Risk Grant Award by the Cancer Prevention and Research Institute of Texas to investigate a novel nanoparticle platform to enhance the effect of chemotherapy and subsequently received an internal grant to transition this platform from the bench to Phase I clinical trials.

Holder’s research interest is investigating the transport of immune cells and metastatic melanoma between primary tumors and lymph nodes to develop innovative prognostic tools and therapeutics.