Spatiotemporal analysis of glioma heterogeneity reveals COL1A1 as an actionable target to disrupt tumor progression
Andrea Comba 1 2 3, Syed M Faisal 1 2 3, Patrick J Dunn 1 2 3, Anna E Argento 1 2, Todd C Hollon 1, Wajd N Al-Holou 1, Maria Luisa Varela 1 2 3, Daniel B Zamler 1 2 3, Gunnar L Quass 4, Pierre F Apostolides 4 5, Clifford Abel 2nd 1 2 3, Christine E Brown 6, Phillip E Kish 1 7, Alon Kahana 7, Celina G Kleer 3 8, Sebastien Motsch 9, Maria G Castro 1 2 3, Pedro R Lowenstein 10 11 12 13
Generation of 3D ex vivo mouse- and patient-derived glioma explant slice model for integration of confocal time-lapse imaging and spatial analysis
Andrea Comba 1, Maria Luisa Varela 2, Syed M Faisal 2, Clifford C Abel 2nd 2, Anna E Argento 3, Wajd N Al-Holou 4, Todd C Hollon 4, Jacqueline D Perelman 5, Patrick J Dunn 2, Sebastien Motsch 6, Maria G Castro 2, Pedro R Lowenstein 7
Uncovering Spatiotemporal Heterogeneity of High-Grade Gliomas: From Disease Biology to Therapeutic Implications
Andrea Comba 1 2 3, Syed M Faisal 1 2 3, Maria Luisa Varela 1 2 3, Todd Hollon 1, Wajd N Al-Holou 1, Yoshie Umemura 1, Felipe J Nunez 4, Sebastien Motsch 5, Maria G Castro 1 2 3, Pedro R Lowenstein 1 2 3
Fyn tyrosine kinase, a downstream target of receptor tyrosine kinases, modulates antiglioma immune responses
Andrea Comba 1 2 3, Patrick J Dunn 1 2 3, Anna E Argento 1 2 3, Padma Kadiyala 1 2 3, Maria Ventosa 1 2 3, Priti Patel 1 2 3, Daniel B Zamler 1 2 3, Felipe J Núñez 1 2 3, Lili Zhao 4, Maria G Castro 1 2 3, Pedro R Lowenstein 1
Scale-free correlations and potential criticality in weakly ordered populations of brain cancer cells
Kevin B Wood 1 2, Andrea Comba 3 4, Sebastien Motsch 5, Tomás S Grigera 6 7 8 9 10, Pedro R Lowenstein 3 4 11 12
The complex interactions between the cellular and non-cellular components of the brain tumor microenvironmental landscape and their therapeutic implications
Syed M Faisal 1 2 3, Andrea Comba 1 2 3, Maria L Varela 1 2 3, Anna E Argento 4, Emily Brumley 1 2 3, Clifford Abel 2nd 1 2 3, Maria G Castro 1 2 3, Pedro R Lowenstein 1 2 3 4
Self-organization in brain tumors: How cell morphology and cell density influence glioma pattern formation
Sara Jamous 1, Andrea Comba 2, Pedro R Lowenstein 2, Sebastien Motsch 1
Laser Capture Microdissection of Glioma Subregions for Spatial and Molecular Characterization of Intratumoral Heterogeneity, Oncostreams, and Invasion
Andrea Comba 1, Patrick J Dunn 1, Phillip E Kish 2, Padma Kadiyala 1, Alon Kahana 3, Maria G Castro 1, Pedro R Lowenstein 4
A novel miR1983-TLR7-IFNβ circuit licenses NK cells to kill glioma cells, and is under the control of galectin-1
Diana Shah 1 2 3 4, Andrea Comba 1 2 3 4, Syed M Faisal 1 2 3 4, Padma Kadiyala 1 2 3 4, Gregory J Baker 1 2 3 4, Mahmoud S Alghamri 1 2 3 4, Robert Doherty 1 2 3 4, Daniel Zamler 1 2 3 4, Gabriel Nuñez 5, Maria G Castro 1 2 3 4, Pedro R Lowenstein 1 2 3 4
Combined cytotoxic and immune-stimulatory gene therapy for primary adult high-grade glioma: a phase 1, first-in-human trial
Yoshie Umemura 1, Daniel Orringer 2, Larry Junck 1, Maria L Varela 3, Molly E J West 3, Syed M Faisal 3, Andrea Comba 3, Jason Heth 2, Oren Sagher 2, Denise Leung 1, Aaron Mammoser 1, Shawn Hervey-Jumper 2, Daniel Zamler 2, Viveka N Yadav 2, Patrick Dunn 2, Wajd Al-Holou 2, Todd Hollon 2, Michelle M Kim 4, Daniel R Wahl 4, Sandra Camelo-Piragua 5, Andrew P Lieberman 5, Sriram Venneti 5, Paul McKeever 5, Theodore Lawrence 4, Ryo Kurokawa 6, Karen Sagher 2, David Altshuler 2, Lili Zhao 7, Karin Muraszko 2, Maria G Castro 3, Pedro R Lowenstein 8
H3.3-G34 mutations impair DNA repair and promote cGAS/STING-mediated immune responses in pediatric high-grade glioma models
Santiago Haase 1 2, Kaushik Banerjee 1 2, Anzar A Mujeeb 1 2, Carson S Hartlage 1 2, Fernando M Núñez 1 2, Felipe J Núñez 1 2, Mahmoud S Alghamri 1 2, Padma Kadiyala 1 2, Stephen Carney 1 2, Marcus N Barissi 1 2, Ayman W Taher 1 2, Emily K Brumley 1 2, Sarah Thompson 1 2, Justin T Dreyer 1 2, Caitlin T Alindogan 1 2, Maria B Garcia-Fabiani 1 2, Andrea Comba 1 2, Sriram Venneti 3, Visweswaran Ravikumar 4, Carl Koschmann 5, Ángel M Carcaboso 6, Maria Vinci 7, Arvind Rao 4 8, Jennifer S Yu 9 10, Pedro R Lowenstein 1 2, Maria G Castro 1 2
Systemic Delivery of an Adjuvant CXCR4-CXCL12 Signaling Inhibitor Encapsulated in Synthetic Protein Nanoparticles for Glioma Immunotherapy
Mahmoud S Alghamri 1 2, Kaushik Banerjee 1 2, Anzar A Mujeeb 1 2, Ava Mauser 3 4, Ayman Taher 1 2, Rohit Thalla 1 2, Brandon L McClellan 1 2 5, Maria L Varela 1 2, Svetlana M Stamatovic 6, Gabriela Martinez-Revollar 6, Anuska V Andjelkovic 1 6, Jason V Gregory 3 7, Padma Kadiyala 1 2, Alexandra Calinescu 1, Jennifer A Jiménez 8, April A Apfelbaum 9 10, Elizabeth R Lawlor 9, Stephen Carney 1 2 10, Andrea Comba 1 2, Syed Mohd Faisal 1 2, Marcus Barissi 1 2, Marta B Edwards 1 2, Henry Appelman 6, Yilun Sun 11, Jingyao Gan 12, Rose Ackermann 12, Anna Schwendeman 3 12, Marianela Candolfi 13, Michael R Olin 14 15, Joerg Lahann 3 7 4, Pedro R Lowenstein 1 2 16 17, Maria G Castro 1 2 16 17
Isolation and characterization of immune cells from the tumor microenvironment of genetically engineered pediatric high-grade glioma models using the sleeping beauty transposon system
Maria Belen Garcia-Fabiani 1, Andrea Comba 1, Padma Kadiyala 1, Santiago Haase 1, Felipe Javier Núñez 1, David Altshuler 1, Pedro Ricardo Lowenstein 1, Maria Graciela Castro 2
Molecular ablation of tumor blood vessels inhibits therapeutic effects of radiation and bevacizumab
Viveka Nand Yadav 1 2, David Altshuler 1, Padma Kadiyala 1 2, Daniel Zamler 1 2, Andrea Comba 1 2, Henry Appelman 3, Patrick Dunn 1 2, Carl Koschmann 1 4, Maria G Castro 1 2, Pedro R Löwenstein 1 2
Arginylated Calreticulin Increases Apoptotic Response Induced by Bortezomib in Glioma Cells
Andrea Comba 1, Laura V Bonnet 1, Victor E Goitea 1, Marta E Hallak 1, Mauricio R Galiano 2
Nuclear Factor of Activated T Cells-dependent Down-regulation of the Transcription Factor Glioma-associated Protein 1 (GLI1) Underlies the Growth Inhibitory Properties of Arachidonic Acid
Andrea Comba 1, Luciana L Almada 2, Ezequiel J Tolosa 2, Eriko Iguchi 2, David L Marks 2, Marianela Vara Messler 3, Renata Silva 3, Maite G Fernandez-Barrena 4, Elisa Enriquez-Hesles 2, Anne L Vrabel 2, Bruno Botta 5, Lucia Di Marcotulio 6, Volker Ellenrieder 7, Aldo R Eynard 3, Maria E Pasqualini 3, Martin E Fernandez-Zapico 2
