To learn more about the research opportunities listed below, please email Dr. Sewell-Loftin at mksewellloftin@uab.edu.
To learn more about the research opportunities listed below, please email Dr. Sewell-Loftin at mksewellloftin@uab.edu.
My lab focuses on how biomechanical factors affect tumor progression and angiogenesis. We primarily utilize a microfluidic device made from poly(dimethylsiloxane), a clear polymer, that allows us to create small tissue mimics that contain multiple human cell lines including fibroblasts and endothelial cells (ECs). The ECs will organize into vascular networks, allowing us to interrogate how different biomechanical parameters (ECM composition, stiffness, etc.) affect blood vessel growth, tumor growth, and metastasis.
Techniques utilized in the lab include the following:
2 and 3D cell culture
Live-cell imaging
Fluorescent microscopy
Mouse models of breast cancer
Microfluidic device design and utilization
Ideal applicants are highly motivated, with a strong work ethic and dedicated to learning new techniques. Students must be willing to work both independently and in a group setting. Please contact Dr. Sewell-Loftin for more information.