Local interactions between innate immune signaling, microbiota, and bile acids drive the development of duodenal adenomas

Juan F Burgueño, Hajar Hazime, Julia Fritsch, Gillian E Jacobsen, Henry D Dione, Trevor Cickovski, Eddy E González, Ana M Santander, Irina Fernández, Nivis Brito, Zhen Gao, Yuguang Ban, Lily Wang, Landon Wilson, Stephen Barnes, Judith Pignac-Kobinger, Mark S Sundrud, Maria T Abreu
Local interactions between innate immune signaling, microbiota, and bile acids drive the development of duodenal adenomas
Cell Mol Gastroenterol Hepatol. 2025 Dec 2:101694. doi: 10.1016/j.jcmgh.2025.101694 PMID: 41344439

Multiomic Analysis of the Gut Microbiome and Serum Metabolome in Response to a Low-Carbohydrate, High-Protein Diet in Individuals With Spinal Cord Injury

Jia Li, Phillip G Popovich, Kristina A Kigerl, Dana M McTigue, Jan Schwab, Stephen Barnes, Ceren Yarar-Fisher
Multiomic Analysis of the Gut Microbiome and Serum Metabolome in Response to a Low-Carbohydrate, High-Protein Diet in Individuals With Spinal Cord Injury
Randomized Controlled Trial Top Spinal Cord Inj Rehabil. 2025 Fall;31(4):111-129. Epub 2025 Nov 18. doi: 10.46292/sci24-00061 PMID: 41268133

Cardiomyocyte-Specific Deletion of Sirtuin 5 Accelerates the Development of Heart Failure Upon Dysregulating Purine Metabolism

Byrne NJ, Koentges C, Pfeil K, Lueg JC, Bakshi S, Tarkhnishvili A, Vosko I, Gollmer J, Birkle LC, Rathner T, Birkle S, Tang S, Rau C, Hoffmann MM, Odening KE, Barnes S, Wilson LS, Ljubojevic-Holzer S, Wallner M, von Lewinski D, Rainer P, Sedej S, Sourij H, Bode C, Wende AR, Zirlik A, Bugger H.
Cardiomyocyte-Specific Deletion of Sirtuin 5 Accelerates the Development of Heart Failure Upon Dysregulating Purine Metabolism..
Acta Physiol (Oxf). 2025 Nov;241(11):e70120. doi: 10.1111/apha.70120 PMID: 41104836

Alterations in mitochondrial energy metabolites following acute subconcussive head impacts among athletes with and without ADHD.

Ellis G, Nowak MK, Kronenberger WG, Recht GO, Ogbeide O, Klemsz LM, Quinn PD, Wilson L, Berryhill T, Barnes S, Newman SD, Kawata K.
Alterations in mitochondrial energy metabolites following acute subconcussive head impacts among athletes with and without ADHD.
iScience. 2025 May 28;28(6):112776. doi: 10.1016/j.isci.2025.112776 eCollection 2025 Jun 20.PMID: 40568316 Free PMC article.

Wheat-based protein slows disease progression in Pkd1 knockout mice.

Hazime H, Ducasa GM, Santander AM, Brito N, Gonzalez-Horta EE, Quintero MA, Barnes S, Wilson L, Zhang Y, Yu F, Gharaibeh RZ, Jobin C, Faust KM, Damas OM, Deshpande A, Kerman DH, Proksell S, Pignac-Kobinger J, Fernández I, Burgueño JF, Abreu MT.
Wheat-based protein slows disease progression in Pkd1 knockout mice.
Gut. 2025 Apr 29:gutjnl-2024-334346. doi: 10.1136/gutjnl-2024-334346. Online ahead of print. PMID: 40301115 Free article.

DUOX2 activation drives bacterial translocation and subclinical inflammation in IBD-associated dysbiosis

Hazime H, Ducasa GM, Santander AM, Brito N, Gonzalez-Horta EE, Quintero MA, Barnes S, Wilson L, Zhang Y, Yu F, Gharaibeh RZ, Jobin C, Faust KM, Damas OM, Deshpande A, Kerman DH, Proksell S, Pignac-Kobinger J, Fernández I, Burgueño JF, Abreu MT.
DUOX2 activation drives bacterial translocation and subclinical inflammation in IBD-associated dysbiosis
Gut. 2025 Apr 29:gutjnl-2024-334346. doi: 10.1136/gutjnl-2024-334346. Online ahead of print.PMID: 40301115 Free article.