The UAB Comprehensive Cancer Center & UAB School of Medicine present:
Scientific Symposium Metabolomics, the underlying basis of disease
Wednesday, December 12, 2012 • UAB Alumni House
Open to faculty, postdoctoral fellows, students and staff
Overview
Metabolomics is the study of the metabolome, the collection of small molecule compounds that are essential for life. They are messengers both within cells and between cells and regulators of epigenetic events. Those produced by bacteria may represent the link between the microbiome and chronic diseases in the human host such as cancer, diabetes and obesity. Nationally recognized experts in metabolomics at the Symposium will describe application of targeted and untargeted approaches for carrying out metabolomics in clinical research, the importance of experimental design, and software-assisted analysis of metabolomics data.
Agenda
Schedule: Download PDF
| Time |
Topics & Speakers |
Resources |
| 7:30-8:00 |
Registration/Breakfast |
|
| 8:00-8:05 |
Symposium Introduction
Krista Casazza, PhD, RD
Assistant Professor of Nutrition Sciences, UAb |
|
| 8:05-8:15 |
UAB and Metabolomics
Robert Kimberly, MD
Associate Dean for Research, UAB |
|
| 8:15-8:35 |
NIH Common Fund Program in Metabolomics
Stephen Barnes, PhD
Professor of Pharmacology & Toxicology, UAB |

(0.8Mb) |
| 8:45-9:25 |
Metabolomics-targeted and translational
Christopher B. Newgard, PhD
Director, Sarah W. Stedman Nutrition and Metabolism Center, Duke University |

(4.1Mb) |
| 9:25-9:35 |
Questions |
|
| 9:35-10:00 |
Experimental design in metabolomics
Grier Page, PhD
Senior Statistical Geneticist at RTI International |

(3.7Mb) |
| 10:00-10:20 |
Coffee Break |
|
| 10:20-10:45 |
Using Metabolomics to Understand Valproate-Induced Obesity in Pediatric Patients with Epilepsy
Andrew Patterson, PhD
Assistant Professor of Molecular Toxicology,
Penn State University |

(4.4Mb) |
| 10:50-11:20 |
Applying Metabolytics™ to Advance Research
Elizabeth Kensicki
Metabolon |
|
| 11:25-11:55 |
Metabonomics – NMR in the clinical environment
Manfred Spraul, PhD
Bruker Daltonics |
|
| Noon |
Lunch and focused expert sessions |
|
| 12:35-12:50 |
SWATH-MS in metabolomics
Brigitte Simons, PhD
AB-Sciex |

(11.2Mb) |
| 1:00-1:30 |
Using Metabolomics to Discover Novel Biomarkers for Common Diseases
David Wishart
Professor of Computing Science, University of Alberta |
|
| 1:40-1:55 |
Oxidized lipids in chronic inflammatory disease
Janusz Kabarowski, PhD
Associate Professor of Microbiology, UAB |
|
| 2:00-2:15 |
NAD metabolism and cell senescence: Role for the NAD glycohydrolase CD38
Frances Lund, PhD
Professor of Microbiology, UAB |
|
| 2:20-2:35 |
Metabolism in the Krebs cycle in breast cancer cells
Keshav Singh, PhD
Professor of Genetics, UAB |
|
| 2:40-2:55 |
Use of Metabolomics to Identify Transcriptional Regulators of Renal Cancer Metabolism
Sunil Sudarshan,
Associate Professor of Urology, UAB |
|
Guided tours of the facilities for metabolomics (in CHEM 153 and MCLM 459) will begin at 3:30 pm
UAB-UCSD O’Brien Center for Acute Kidney Injury
Center for Free Radical Biology
Nutrition Obesity Research Center (NORC)
UAB Comprehensive Cardiovascular Center
UAB Comprehensive Diabetes Center
UAB Diabetes Research and Training Center (DRTC)
Metabolon
BRUKER
AB Sciex