Stephen Barnes, PhD

(University of London, 1972, Biochemistry)
University of Alabama at Birmingham
Department of Pharmacology and Toxicology
BBRB 711 (UAB OneCard access required)
845 19th St S
Birmingham, AL 35205
Tel: (205) 934-7117
Fax: (205) 934-6944
E-mail. sbarnes@uab.edu

Academic Appointments:

Professor of Pharmacology & Toxicology (1994-present)
Professor of Biochemistry & Molecular Genetics (1997-present)
Professor of Environmental Health Sciences (2000-present)
Professor of Genetics (2000-present)
Professor of Vision Science (2006-present)

Other appointments:

Director, Targeted Metabolomics and Proteomics Laboratory (2009-present)
Senior Scientist, Comprehensive Cancer Center
Senior Scientist, Center for Aging
Associate Director, Purdue-UAB Botanicals
Center for Age-related Disease
Director, Center Nutrient-Gene Interaction in Cancer Prevention
Senior Scientist, Nephrology Research and Training Center (2008-present)
Senior Scientist, Center for Metabolic Bone Disease (2006-present)
Senior Scientist, Center for Free Radical Biology (1999-present)
Senior Scientist, Nutrition Obesity Research Center (2000-present)

Publications

2024 Publications

  1. Lu Y, Osis G, Zmijewska AA, Traylor A, Thukral S, Wilson L, Barnes S, George JF, Agarwal A.
    Macrophage-Specific Lactate Dehydrogenase Expression Modulates Inflammatory Function In Vitro
    Kidney360. 2024 Nov 12. doi: 10.34067/KID.0000000630 Online ahead of print.
  2. Jeevan K. Prasain, Stephen Barnes.
    Recent updates on diet-derived gut microbial metabolites
    eFood. 26 July 2024 doi: 10.1002/efd2.181
  3. Coler EA, Melnik A, Lotfi A, Moradi D, Ahiadu B, Gomes PWP, Patan A, Dorrestein PC, Barnes S, Boginski V, Semenov A, Aksenov AA.
    Ordering molecular diversity in untargeted metabolomics via molecular community networking.
    bioRxiv [Preprint]. 2024 Aug 7:2024.08.02.606356. doi: 10.1101/2024.08.02.606356. PMID: 39131284
  4. Yamaguchi S, Sedaka R, Kapadia C, Huang J, Hsu JS, Berryhill TF, Wilson L, Barnes S, Lovelady C, Oduk Y, Williams RM, Jaimes EA, Heller DA, Saigusa T.
    Rapamycin-encapsulated nanoparticle delivery in polycystic kidney disease mice
    Sci Rep. 2024 Jul 2;14(1):15140. doi: 10.1038/s41598-024-65830-7 PMID: 38956234
  5. Baptista LC, Wilson L, Barnes S, Anton SD, Buford TW.
    Effects of resveratrol on changes in trimethylamine-N-oxide and circulating cardiovascular factors following exercise training among older adults
    Exp Gerontol. 2024 Jun 11:112479. doi: 10.1016/j.exger.2024.112479. Online ahead of print.

2023 Publications

  1. Jillian F Ziemanski, Landon Wilson, Stephen Barnes, Kelly K Nichols
    Evaluation of the effects of latanoprost and benzalkonium chloride on the cell viability and nonpolar lipid profile produced by human meibomian gland epithelial cells in culture
    Mol Vis. 2023 Nov 6:29:289-305. eCollection 2023. PMID: 38264609 PMCID: PMC10805331
  2. Ekta Tiwary, Taylor F Berryhill, Landon Wilson, Stephen Barnes, Jeevan K Prasain, J Michael Wells
    LC-MS/MS method for proline-glycine-proline and acetylated proline-glycine-proline in human plasma
    J Chromatogr B Analyt Technol Biomed Life Sci. 2023 Jul 5;1228:123815. PMID: 37453387 doi: 10.1016/j.jchromb.2023.123815 Online ahead of print.
  3. Jordan SJ, Wilson L, Ren J, Gupta K, Barnes S, Geisler WM..
    Natural clearance of Chlamydia trachomatis infection is associated with distinct differences in cervicovaginal metabolites.
    J Infect Dis. 2023 May 11:jiad155. Online ahead of print.PMID: 37163744 doi: 10.1093/infdis/jiad155
  4. Livelo C, Guo Y, Abou Daya F, Rajasekaran V, Varshney S, Le HD, Barnes S, Panda S, Melkani GC.
    Time-restricted feeding promotes muscle function through purine cycle and AMPK signaling in Drosophila obesity models.
    Nat Commun. 2023 Feb 21;14(1):949. PMID: 36810287 PMCID: PMC9944249 doi: 10.1038/s41467-023-36474-4

2022 Publications

  1. Srivastava O, Wilson L, Barnes S, Srivastava K, Joseph R.
    αA and αB peptides from human cataractous lenses show antichaperone activity and enhance aggregation of lens proteins
    Mol Vis. 2022 Aug 6;28:147-164. eCollection 2022. PMID: 36540064
  2. Brothwell JA, Fortney KR, Gao H, Wilson LS, Andrews CF, Tran TM, Hu X, Batteiger TA, Barnes S, Liu Y, Spinola SM.
    Haemophilus ducreyi Infection Induces Oxidative Stress, Central Metabolic Changes, and a Mixed Pro- and Anti-inflammatory Environment in the Human Host.
    mBio. 2022 Dec 1:e0312522. [doi:10.1128/mbio.03125-22] Online ahead of print.PMID: 36453940
  3. Dianna Xing, Gloria A Benavides, Michelle S Johnson, Ran Tian, Stephen Barnes, Victor M Darley-Usmar
    Glutamine-dependent effects of nitric oxide on cancer cells subjected to hypoxia-reoxygenation
    Nitric Oxide. 2022 Nov 19;S1089-8603(22)00122-7. [doi:10.1016/j.niox.2022.11.003] PMID: 36414197
  4. Prasain JK, Wilson LS, Grubbs C, Barnes S.
    Gamma-ray Irradiation of Rodent Diets Alters the Urinary Metabolome in Rats with Chemically Induced Mammary Cancer.
    Metabolites. 2022 Oct 16;12(10):976. [doi:10.3390/metabo12100976] PMID: 36295878
  5. Carson TL, Buro AW, Miller D, Pena A, Ard JD, Lampe JW, Yi N, Lefkowitz E, William VP, Morrow C, Wilson L, Barnes S, Demark-Wahnefried W.
    Rationale and study protocol for a randomized controlled feeding study to determine the structural- and functional-level effects of diet-specific interventions on the gut microbiota of non-Hispanic black and white adults.
    Contemp Clin Trials. 2022 Oct 17:106968. [doi:10.1016/j.cct.2022.106968] Online ahead of print. PMID:36265810
  6. Chehade SB, Green GBH, Graham CD, Chakraborti A, Vashai B, Moon A, Williams MB, Vickers B, Berryhill T, Van Der Pol W, Wilson L, Powell ML, Smith DL Jr, Barnes S, Morrow C, Mukhtar MS, Kennedy GD, Bibb JA, Watts SA.
    A modified standard American diet induces physiological parameters associated with metabolic syndrome in C57BL/6J mice.
    Front Nutr. 2022 Aug 29;9:929446. [doi:10.3389/fnut.2022.929446] eCollection 2022. PMID: 36105576
  7. Mahmoudi Aliabadi P, Teuber R, Jani PK, Wilson L, Enghard P, Barnes S, Chiorazzi N, Radbruch A, Melchers F, Kubagawa H.
    Soluble Fc Receptor for IgM in Sera From Subsets of Patients With Chronic Lymphocytic Leukemia as Determined by a New Mouse Monoclonal Antibody.
    Front Immunol. 2022 Jun 16;13:863895. [doi: 10.3389/fimmu.2022.863895] eCollection 2022.PMID: 35784336
  8. Newman SD, Schnakenberg Martin AM, Raymond D, Cheng H, Wilson L, Barnes S, O’Donnell BF.
    The relationship between cannabis use and taurine: A MRS and metabolomics study.
    PLoS One. 2022 Jun 2;17(6):e0269280. [doi: 10.1371/journal.pone.0269280] eCollection 2022. PMID: 35653401
  9. Li J, Morrow C, Barnes S, Wilson LS, Womack ED, McLain A, Yarar-Fisher C.
    Gut Microbiome Composition and Serum Metabolome Profile Among Individuals With Spinal Cord Injury and Normal Glucose Tolerance or Prediabetes/Type 2 Diabetes.
    Arch Phys Med Rehabil. 2022 Apr;103(4):702-710. [doi: 10.1016/j.apmr.2021.03.043]

2021 Publications

  1. Khanal S, Bai Y, Ngo W, Nichols KK, Wilson L, Barnes S, Nichols JJ.
    Human meibum and tear film derived cholesteryl and wax esters in meibomian gland dysfunction and tear film structure.
    Ocul Surf. 2021 Nov 11;23:12-23. [doi: 10.1016/j.jtos.2021.10.009] Online ahead of print.PMID: 34774809
  2. Pak HH, Haws SA, Green CL, Koller M, Lavarias MT, Richardson NE, Yang SE, Dumas SN, Sonsalla M, Bray L, Johnson M, Barnes S, Darley-Usmar V, Zhang J, Yen CE, Denu JM, Lamming DW.
    Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice.
    Nature Metabolism. 2021 Oct 18. [doi: 10.1038/s42255-021-00466-9] Online ahead of print.PMID: 34663973
  3. Raines NH, Cheung MD, Wilson LS, Edberg JC, Erdmann NB, Schmaier AA, Berryhill TF, Manickas-Hill Z, Li JZ, Yu XG, Agarwal A, Barnes S, Parikh SM.
    NAD+ biosynthetic impairment and urinary metabolomic alterations observed in hospitalized adults with COVID-19-related acute kidney injury
    Kidney Int Rep. 2021 Sep 14. [doi: 10.1016/j.ekir.2021.09.001] Online ahead of print. PMID: 34541422
  4. Ziemanski JF, Wilson L, Barnes S, Nichols KK.
    Prostaglandin E2 and F2α Alter Expression of Select Cholesteryl Esters and Triacylglycerols Produced by Human Meibomian Gland Epithelial Cells
    Cornea. 2021 Sep 4. [doi: 10.1097/ICO.0000000000002835] Online ahead of print. PMID: 34483274.
  5. Jeevan K. Prasain, Stephen Barnes, J. Michael Wyss
    Kudzu isoflavone C-glycosides: Analysis, biological activities, and metabolism
    Food Frontiers. First published: 06 August 2021. [doi: 10.1002/fft2.105]
  6. Jia Li, Casey Morrow, Stephen Barnes, Landon Wilson, Erika D Womack, Amie McLain, Ceren Yarar-Fisher
    Gut microbiome composition and serum metabolome profile among individuals with spinal cord injury and normal glucose tolerance or prediabetes/type 2 diabetes
    Arch Phys Med Rehabil. 2021 Jun 11;S0003-9993(21)00438-X. [doi: 10.1016/j.apmr.2021.03.043] Online ahead of print.
  7. Safal Khanal, Yuqiang Bai, William Ngo, Kelly K Nichols, Landon Wilson, Stephen Barnes, Jason J Nichols
    Human Meibum and Tear Film Derived (O-Acyl)-Omega-Hydroxy Fatty Acids as Biomarkers of Tear Film Dynamics in Meibomian Gland Dysfunction and Dry Eye Disease
    Invest Ophthalmol Vis Sci. 2021 Jul 1;62(9):13. [doi: 10.1167/iovs.62.9.13] PMID: 34236383.
  8. Khanal S, Ngo W, Nichols KK, Wilson L, Barnes S, Nichols JJ.
    Human meibum and tear film derived (o-acyl)-omega-hydroxy fatty acids in meibomian gland dysfunction.
    Ocul Surf. 2021 May 27:S1542-0124(21)00048-3. [doi: 10.1016/j.jtos.2021.05.009] Online ahead of print. PMID: 34052415.
  9. Ayanabha Chakraborti, Christopher Graham, Sophie Chehade, Bijal Vashi, Alan Umfress, Pradeep Kurup, Benjamin Vickers, H. Alexander Chen, Rahul Telange, Taylor Berryhill, William Van Der Pol, Mickie Powell, Stephen Barnes, Casey Morrow, Daniel L. Smith Jr., M. Shahid Mukhtar, Stephen Watts, Gregory Kennedy and James Bibb
    High Fructose Corn Syrup-Moderate Fat Diet Potentiates Anxio-Depressive Behavior and Alters Ventral Striatal Neuronal Signaling
    Front. Neurosci., 26 May 2021. [doi: 10.3389/fnins.2021.669410]
  10. Jillian F Ziemanski, Landon Wilson, Stephen Barnes, Kelly K Nichols
    Triacylglycerol lipidome from human meibomian gland epithelial cells: Description, response to culture conditions, and perspective on function
    Exp Eye Res. 2021 Apr 10;108573. [doi: 10.1016/j.exer.2021.108573] Online ahead of print
  11. Lisa M Curtis, James George, Volker Vallon, Stephen Barnes, Victor M Darley-Usmar, Sucheta Mukul Vaingankar, Gary Cutter, Orlando Gutierrez, Michael Seifert, Joachim Ix, Ravindra Mehta, Paul W Sanders, Anupam Agarwal
    UAB-UCSD O’Brien Center for Acute Kidney Injury Research
    Am J Physiol Renal Physiol. 2021 Mar 29. [doi: 10.1152/ajprenal.00661.2020] [PMID: 33779316] Online ahead of print.
  12. Mark Messina, Sonia Blanco Mejia, Aedin Cassidy, Alison Duncan, Mindy Kurzer, Chisato Nagato, Martin Ronis, Ian Rowland, John Sievenpipe, Stephen Barnes
    Neither soyfoods nor isoflavones warrant classification as endocrine disruptors: a technical review of the observational and clinical data
    Crit Rev Food Sci Nutr. 2021 Mar 27;1-57. [doi: 10.1080/10408398.2021.1895054] [PMID: 33775173]
  13. Oak ASW, Shafi R, Elsayed M, Mishra B, Bae S, Barnes S, Kashyap MP, Slominski AT, Wilson LS, Athar M, Elmets CA
    Dietary table grape protects against UV photodamage in humans: 2. molecular biomarker studies.
    J Am Acad Dermatol. 2021 Jan 20:S0190-9622(21)00184-5. [doi: 10.1016/j.jaad.2021.01.036] Online ahead of print. [PMID: 33484768]

2020 Publications

  1. Jeevan K. Prasain, Stephen Barnes
    Cranberry polyphenols‐gut microbiota interactions and potential health benefits: An updated review
    Food Frontiers. Dec 30, 2020. [doi: 10.1002/fft2.56]

  2. Zengul AG, Demark-Wahnefried W, Barnes S, Morrow CD, Bertrand B, Berryhill TF, Frugé AD.
    Associations Between Dietary Fiber, the Fecal Microbiota and Estrogen Metabolism in Postmenopausal Women With Breast Cancer
    Nutr Cancer. 2020 Jun 26:1-10. [doi: 10.1080/01635581.2020.1784444] Online ahead of print.PMID: 32590914

  3. Manvi Sharma, Itika Arora, Matthew L. Stoll, Yuanyuan Li, Casey D. Morrow, Stephen Barnes, Taylor F. Berryhill, Shizhao Li, Trygve O. Tollefsbol
    Nutritional combinatorial impact on the gut microbiota and plasma short-chain fatty acids levels in the prevention of mammary cancer in Her2/neu estrogen receptor-negative transgenic mice
    [doi: 10.1101/2020.06.08.139865]

  4. Sharma NS, Vestal G, Wille K, Patel KK, Tipparaju S, Patel K, Menon S, Gaggar A, Xu X, Tousif S, Cheng F, Barnes S, Wilson LS, Lal CV, Dishaw L, Weill D, Dunning J, Hayes, Jr. D, Deshane JS, Liu R.
    Differences in airway microbiome and metabolome of single lung transplant recipients.
    J Clin Invest. 2019 Oct 14. pii: 127959. 2020 May 6;21(1):104. Respir Res. [PMC7201609]
    [doi:10.1186/s12931-020-01367-3 ]

  5. Hoffman JM, Poonawalla A, Icyuz M, Swindell WR, Wilson L, Barnes S, Sun LY.
    Transcriptomic and metabolomic profiling of long-lived growth hormone releasing hormone knock-out mice: evidence for altered mitochondrial function and amino acid metabolism.
    Aging (Albany NY). 2020 Feb 23;12. [doi: 10.18632/aging.102822] [Epub ahead of print]
    PMID:32091406

  6. Barnes S
    Overview of Experimental Methods and Study Design in Metabolomics, and Statistical and Pathway Considerations.
    Methods Mol Biol. 2020;2104:1-10. [doi: 10.1007/978-1-0716-0239-3_1] PMID:31953809

  7. Prasain, Jeevan K., Grubbs, Clinton, Barnes, Stephen.
    Cranberry anti-cancer compounds and their uptake and metabolism: An updated review.
    Journal of Berry Research, vol. 10, no. 1, pp. 1-10, 2020. [DOI: 10.3233/JBR-180370]