Juan F Burgueño, Hajar Hazime, Julia Fritsch, Gillian E Jacobsen, Henry D Dione, Trevor Cickovski, Eddy E González, Ana M Santander, Irina Fernández, Nivis Brito, Zhen Gao, Yuguang Ban, Lily Wang, Landon Wilson, Stephen Barnes, Judith Pignac-Kobinger, Mark S Sundrud, Maria T Abreu
Local interactions between innate immune signaling, microbiota, and bile acids drive the development of duodenal adenomas
Cell Mol Gastroenterol Hepatol. 2025 Dec 2:101694. doi: 10.1016/j.jcmgh.2025.101694 PMID: 41344439
Multiomic Analysis of the Gut Microbiome and Serum Metabolome in Response to a Low-Carbohydrate, High-Protein Diet in Individuals With Spinal Cord Injury
Jia Li, Phillip G Popovich, Kristina A Kigerl, Dana M McTigue, Jan Schwab, Stephen Barnes, Ceren Yarar-Fisher
Multiomic Analysis of the Gut Microbiome and Serum Metabolome in Response to a Low-Carbohydrate, High-Protein Diet in Individuals With Spinal Cord Injury
Randomized Controlled Trial Top Spinal Cord Inj Rehabil. 2025 Fall;31(4):111-129. Epub 2025 Nov 18. doi: 10.46292/sci24-00061 PMID: 41268133
MetaboNews – Nov 2025
Volume 15, Issue 11 — November 2025: Nathan Ghafari & SHARP Metabolomics
Botanicals Research: Progress, Priorities and Possibilities
The Centers for Advancement in Research on Botanicals and Natural Products (CARBON) had a celebration for 25 years of research investment by the NIH.
Dr. Stephen Barnes, was the Chair of the first CARBON Study Section and with Connie Weaver he ran the Purdue-UAB Botanicals Research Center from 2000-2010.
He was invited to give the plenary talk to begin the meeting. He spoke on how he became interested in botanicals research, the period of funding, what this led to in his career and where botanicals research might be headed (off this planet). He also pointed out the differences between plant organics and the artificial compounds created by modern society and, in particular, the substantial contamination by them that is occurring.
The Historical Curve Leading to Modern Metabolomics – ISMRM 2025
ISMRM Workshop on Frontiers in Metabolomics & Metabolomic Imaging in Medicine: Challenges & Opportunities – Cultural Center Altinate San Gaetano, Padua, Italy
16-18 October 2025
Session 4: Multi-Modality Technologies & Imaging
Day 2 – Friday, 17 October 2025
Keynote: The Historical Curve Leading to Modern Metabolomics
Stephen Barnes, Ph.D.
University of Alabama at Birmingham
Birmingham, AL, USA
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Cardiomyocyte-Specific Deletion of Sirtuin 5 Accelerates the Development of Heart Failure Upon Dysregulating Purine Metabolism
Byrne NJ, Koentges C, Pfeil K, Lueg JC, Bakshi S, Tarkhnishvili A, Vosko I, Gollmer J, Birkle LC, Rathner T, Birkle S, Tang S, Rau C, Hoffmann MM, Odening KE, Barnes S, Wilson LS, Ljubojevic-Holzer S, Wallner M, von Lewinski D, Rainer P, Sedej S, Sourij H, Bode C, Wende AR, Zirlik A, Bugger H.
Cardiomyocyte-Specific Deletion of Sirtuin 5 Accelerates the Development of Heart Failure Upon Dysregulating Purine Metabolism..
Acta Physiol (Oxf). 2025 Nov;241(11):e70120. doi: 10.1111/apha.70120 PMID: 41104836
UAB Heersink School of Medicine announces 2024/2025 Multi-PI Award recipients
May 06, 2025
Written by: Katherine Kirk
The UAB Heersink School of Medicine is proud to announce the recipients of the 2024/2025 Multi-PI Awards, each funded with $150,000 per year for two years. These awards recognize outstanding collaborative research efforts aimed at addressing critical health challenges. This year’s awardees are Amit Gaggar, M.D., Ph.D., professor of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, and Timmy Lee, M.D., MSPH, professor of Medicine, Division of Nephrology. Their multidisciplinary approaches and groundbreaking research promise to advance scientific knowledge and significantly improve patient outcomes.
“We are immensely proud of our faculty for their exceptional research achievements,” said Tika Benveniste, Ph.D., senior vice dean, UAB Heersink School of Medicine, associate vice president for Medicine and Basic Sciences. “These awards will further advance their research efforts and significantly enhance the field of medicine.”
Understanding COPD exacerbations
Gaggar and his team will study “The impact of vascular dysfunction on acute exacerbations of COPD,” focusing on understanding the immunological mechanisms leading to cardiovascular complications during and after chronic obstructive pulmonary disease (COPD) exacerbations.
“This research aims to examine the host immune response during acute COPD exacerbations and its link to cardiovascular dysfunction, which significantly increases mortality risk,” Gaggar said. “We hope to improve patient outcomes and survival rates by identifying biomarkers and therapeutic targets for these complications.”
The study’s priorities include evaluating immunity and inflammation during exacerbation of chronic obstructive pulmonary disease (ECOPD), utilizing advanced technologies like metabolomics and spatial transcriptomics, and addressing issues related to access to care for COPD patients. A multidisciplinary approach, leveraging expertise in immunology, cardiovascular research, metabolomics, and animal modeling, is crucial for comprehensively understanding and addressing the complex interactions between COPD exacerbations and cardiovascular events. The funding will support the recruitment of study subjects, assay, and specimen processing, and the development of a novel murine model for mechanistic studies. Ultimately, this study could lead to the discovery of new biomarkers and therapeutic targets, potentially reducing the mortality and morbidity associated with COPD exacerbations, particularly from cardiovascular complications.
The research team includes Gregory Payne, M.D., Ph.D., Department of Medicine, Division of Cardiovascular Disease; Rakesh Patel, Ph.D., Department of Pathology, Division of Molecular and Cellular Pathology; Jarrod Barnes, Ph.D., Department of Medicine, Division of Pulmonary, Allergy, & Critical Care Medicine; and Michael Wells, M.D., MSPH, Department of Medicine, Division of Pulmonary, Allergy, & Critical Care Medicine; all bringing diverse expertise to this innovative and impactful project.
TMPL Joins Lung Biology Program
We are pleased to announce that the Targeted Metabolomics and Proteomics Laboratory (TMPL) has officially transitioned from the Department of Pharmacology to join the Lung Biology Program, led by Dr. Amit Gaggar, within the Division of Pulmonary, Allergy, and Critical Care Medicine. Under the continued guidance of Dr. Stephen Barnes, Emeritus Director, TMPL is positioned to make a significant impact on our research efforts. Equipped with cutting-edge instrumentation, including the SCIEX ZenoTOF 7600+ mass spectrometer, TMPL will further drive innovation and excellence in pulmonary research. If you have any questions or project-related ideas, please feel free to reach out to either Dr. Amit Gaggar (agaggar@uabmc.edu) or Dr. Stephen Barnes (sbarnes@uab.edu).
Alterations in mitochondrial energy metabolites following acute subconcussive head impacts among athletes with and without ADHD.
Ellis G, Nowak MK, Kronenberger WG, Recht GO, Ogbeide O, Klemsz LM, Quinn PD, Wilson L, Berryhill T, Barnes S, Newman SD, Kawata K.
Alterations in mitochondrial energy metabolites following acute subconcussive head impacts among athletes with and without ADHD.
iScience. 2025 May 28;28(6):112776. doi: 10.1016/j.isci.2025.112776 eCollection 2025 Jun 20.PMID: 40568316 Free PMC article.
Wheat-based protein slows disease progression in Pkd1 knockout mice.
Hazime H, Ducasa GM, Santander AM, Brito N, Gonzalez-Horta EE, Quintero MA, Barnes S, Wilson L, Zhang Y, Yu F, Gharaibeh RZ, Jobin C, Faust KM, Damas OM, Deshpande A, Kerman DH, Proksell S, Pignac-Kobinger J, Fernández I, Burgueño JF, Abreu MT.
Wheat-based protein slows disease progression in Pkd1 knockout mice.
Gut. 2025 Apr 29:gutjnl-2024-334346. doi: 10.1136/gutjnl-2024-334346. Online ahead of print. PMID: 40301115 Free article.
