The electrophilic metabolite of kynurenine, kynurenine-CKA, requires C151 in Keap1 to derepress Nrf2.

Feng J, Carreño M, Jung H, Dayalan Naidu S, Arroyo-Diaz N, Ang AD, Kulkarni B, Kisielewski D, Suzuki T, Yamamoto M, Hayes JD, Honda T, Wilson L, Leon-Ruiz B, Eggler AL, Vitturi DA, Dinkova-Kostova AT.
The electrophilic metabolite of kynurenine, kynurenine-CKA, requires C151 in Keap1 to derepress Nrf2. Redox Biol. 2026 Jan 6;90:104009. doi: 10.1016/j.redox.2026.104009. Online ahead of print.PMID: 41534303 Free article.