Human TB Tissues

Many critical questions regarding human TB cannot be addressed by a single laboratory, research group, or technological platform.

Through the GRR-HTB, investigators worldwide can confidentially test new hypotheses by requesting analysis of TB tissues that display specific TB-related pathophysiologies.

Available Human TB specimens

• Anti-TB drug-treated or untreated flash-frozen, formalin-fixed, or RNAlater-preserved (with corresponding tissue CFU burden) tuberculous lung tissue containing the full histopathological spectrum of lesions i.e., caseous, necrotic, nonnecrotic, fibrotic (healed scar), partial/fully calcified necrotic, cavitary lesions etc.
• Anti-TB drug-treated or untreated extrapulmonary TB specimens; combination of resected and postmortem specimens (brain, spleen, liver, kidney, heart, testis, urethra, range of lymph nodes, bone marrow, etc.) stored as described above.
• Postmortem specimens from decedents who died of causes other than TB. Lungs and major organs stored as described above.
• Postmortem specimens from incidental TB cases. Predominantly lungs, including, but not limited to the major organs stored as described above.