MHCII is required for α-synuclein-induced activation of microlia, CD4 T cell proliferation, and dopaminergic neurodegeneration.
https://www.ncbi.nlm.nih.gov/pubmed/23739956
The gamma chain subunit of Fc receptors is required for alpha-synuclein-induced pro-inflammatory signaling in microglia.
https://www.ncbi.nlm.nih.gov/pubmed/23186369
Fcγ receptors are required for NF-κB signaling, microglial activation and dopaminergic neurodegeneration in an AAV-synuclein mouse model of Parkinson’s disease.
https://www.ncbi.nlm.nih.gov/pubmed/20977765
Targeted overexpression of human alpha-synuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson disease.
https://www.ncbi.nlm.nih.gov/pubmed/19018246
