The retina of the eye can determine the sign of image defocus using environmental visual cues and guide the growth of the eye in a sign-dependent manner. However, the specific retinal neural circuitry underlying the retinal detection of visual cues and generation of growth signals is unclear. In addition, how the contemporary optical and pharmacological interventions act to slow the progression of myopia remains poorly understood. Our lab uses in vivo advanced electrophysiology techniques in tree shrews and humans to investigate the role of different retinal neurons in eye growth regulation and myopiagenesis.

  1. Khanal S, Ousterhout A. Short-wavelength-sensitive cone retinal pathway activity in myopes and non-myopes. Invest. Ophthalmol. Vis. Sci. 2023;64(8):4366.
  2. Khanal S, Sanchez-Castellanos. S-cone Retinal Pathway Activity Responses to Optical Defocus in Myopes and Non-myopes. AAO, October 11-14, 2023, New Orleans, LA, USA (Paper)
  3. Khanal S, Rathod SN, Phillips JR. The acute effect of atropine eye drops on the human full-field electroretinogram. Doc Ophthalmol. 2021 Jun;142(3):315-328. PMID: 33231734.
  4. Khanal S, Turnbull PRK, Lee N, Phillips JR. The Effect of Atropine on Human Global Flash mfERG Responses to Retinal Defocus. Invest Ophthalmol Vis Sci. 2019 Jan;60(1):218-225. PMID: 30641550.